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Aggregation of mutant cysteine string protein-α via Fe–S cluster binding is mitigated by iron chelators
Point mutations in cysteine string protein-α (CSPα) cause dominantly inherited adult-onset neuronal ceroid lipofuscinosis (ANCL), a rapidly...
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Regulatory Mechanisms of Photosynthetic CO2 Fixation in Unicellular Microbes
Aquatic photoautotrophs, such as microalgae and cyanobacteria, contribute 50% of carbon assimilated into organic matter through their carbon fixation... -
Current analysis of cations substitution in the oxygen-evolving complex of photosystem II
Water oxidation in photosystem II (PSII) is performed by the oxygen-evolving complex Mn 4 CaO 5 which can be extracted from PSII and then reconstructed...
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Reconstruction of HydSL Hydrogenase from Thiocapsa roseopersicina after Cyanide Inhibition
AbstractIt is shown that the catalytic center of Thiocapsa roseopersicina remains active after prolonged treatment with cyanide. It was found that...
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Bacterial microcompartments for isethionate desulfonation in the taurine-degrading human-gut bacterium Bilophila wadsworthia
BackgroundBilophila wadsworthia , a strictly anaerobic, sulfite-reducing bacterium and common member of the human gut microbiota, has been associated...
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Reconstitution, characterization, and [2Fe–2S] cluster exchange reactivity of a holo human BOLA3 homodimer
A new class of mitochondrial disease has been identified and characterized as Multiple Mitochondrial Dysfunctions Syndrome (MMDS). Four different...
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Metabolic engineering of Escherichia coli for the production of (R)-α-lipoic acid
ObjectiveTo increase the production of (R)-α-lipoic acid directly from octanoic acid using engineered Escherichia coli with the regeneration of...
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RNA transcript response by an Acidithiobacillus spp. mixed culture reveals adaptations to growth on arsenopyrite
Biooxidation of gold-bearing refractory mineral ores such as arsenopyrite (FeAsS) in stirred tanks produces solutions containing highly toxic arsenic...
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Human frataxin, the Friedreich ataxia deficient protein, interacts with mitochondrial respiratory chain
Friedreich ataxia (FRDA) is a rare, inherited neurodegenerative disease caused by an expanded GAA repeat in the first intron of the FXN gene, leading...
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Diversity of Thermophilic Prokaryotes Inhabiting Russian Natural Hot Springs
AbstractIn this review, we highlight the key results of studies on the diversity of thermophilic prokaryotes inhabiting the Russian Federation’s hot...
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Anaerobic derivates of mitochondria and peroxisomes in the free-living amoeba Pelomyxa schiedti revealed by single-cell genomics
BackgroundMitochondria and peroxisomes are the two organelles that are most affected during adaptation to microoxic or anoxic environments....
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Deferrivibrio essentukiensis sp. nov., gen. nov., a Representative of Deferrivibrionaceae fam. nov., Isolated from the Subsurface Aquifer of Caucasian Mineral Drinking Waters
AbstractThe Yessentukskoye deposit of Caucasian mineral waters contains balneologically valuable drinking mineral water, which is extracted from the...
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Niche differentiation of sulfur-oxidizing bacteria (SUP05) in submarine hydrothermal plumes
Hydrothermal plumes transport reduced chemical species and metals into the open ocean. Despite their considerable spatial scale and impact on...
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Gene expression profile of Campylobacter jejuni in response to macrolide antibiotics
Campylobacter jejuni is a foodborne pathogen that causes gastroenteritis in humans and has developed resistance to various antibiotics. The primary...
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Population structure and SNP detection for phytic acid, Fe and Zn in sorghum (Sorghum bicolor [L.] Moench)
Mineral malnutrition is a major challenge worldwide, particularly in develo** countries where approximately 50% of children are reported to have...
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H-cluster assembly intermediates built on HydF by the radical SAM enzymes HydE and HydG
Abstract[FeFe]-hydrogenase catalyzes the reversible reduction of protons to H 2 at a complex metallocofactor site, the H-cluster. Biosynthesis of...
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Acclimation of the photosynthetic apparatus to low light in a thermophilic Synechococcus sp. strain
Depending upon their growth responses to high and low irradiance, respectively, thermophilic Synechococcus sp. isolates from microbial mats...
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The indispensable role of mammalian iron sulfur proteins in function and regulation of multiple diverse metabolic pathways
In recent years, iron sulfur (Fe–S) proteins have been identified as key players in mammalian metabolism, ranging from long-known roles in the...
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Complex Endosymbiosis II: The Nonphotosynthetic Plastid of Apicomplexa Parasites (The Apicoplast) and Its Integrated Metabolism
Chloroplasts are essential organelles that are responsible for photosynthesis in a wide range of organisms that have colonized all biotopes on Earth... -
Clinical and genetic aspects of defects in the mitochondrial iron–sulfur cluster synthesis pathway
Iron–sulfur clusters are evolutionarily conserved biological structures which play an important role as cofactor for multiple enzymes in eukaryotic...