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In vivo safety and biodistribution profile of Klotho-enhanced human urine-derived stem cells for clinical application
BackgroundUrine-derived stem cells (UDSCs) can be easily isolated from urine and possess excellent stem cell characteristics, making them a promising...
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Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation
Current pharmacological therapies for treating obesity are of limited efficacy. Genetic ablation or loss of function of AMP-activated protein kinase...
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The Five-Year Effect of a Single Zoledronate Infusion on Bone Mineral Density Following Denosumab Discontinuation in Women with Postmenopausal Osteoporosis
The long-term effects of zoledronate treatment in women with postmenopausal osteoporosis who stop denosumab therapy when they become osteopenic are...
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In Vivo Evaluation of Exon 51 Skip** in hDMD/Dmd-null Mice
Duchenne muscular dystrophy (DMD) is a fatal X-linked condition that affects 1 in 3500–6000 newborn boys a year. An out-of-frame mutation in the DMD...
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The bone–liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway
Mesenchymal stromal cells (MSCs) are used to treat infectious and immune diseases and disorders; however, its mechanism(s) remain incompletely...
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Advancements in small interfering RNAs therapy for acute lymphoblastic leukemia: promising results and future perspectives
Acute lymphoblastic leukemia (ALL) is the most common type of cancer among children, presenting significant healthcare challenges for some patients,...
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Аnticoagulation Effects of Leucine-Containing Glyprolines in Hypercoagulation
AbstractThe effects of two leucine-containing glyproline peptides Leu-Pro-Gly-Pro and Pro-Gly-Pro-Leu, including leucine from the N- and C-ends of...
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Therapeutic normal IgG intravenous immunoglobulin activates Wnt-β-catenin pathway in dendritic cells
Therapeutic normal IgG intravenous immunoglobulin (IVIG) is a well-established first-line immunotherapy for many autoimmune and inflammatory...
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Co-treatment with grape seed extract and mesenchymal stem cells in vivo regenerated beta cells of islets of Langerhans in pancreas of type I-induced diabetic rats
BackgroundNowadays, diabetes mellitus is known as a silent killer because individual is not aware that he has the disease till the development of its...
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Silica-Capped and Gold-Decorated Silica Nanoparticles for Enhancing Effect of Gold Nanoparticle-Based Photothermal Therapy
Background:Various methods based on gold nanoparticles (AuNPs) have been applied to enhance the photothermal effect. Among these methods, combining...
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Peripheral Administration of an Opioid Peptide Analog Ameliorates Morphine-Produced Hyperalgesia in a Spared Nerve Injury Model
Traditional opioids have proven analgesic effects in clinical applications but are also associated with side effects, especially hyperalgesia....
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Mesenchymal stromal cell therapy for COVID-19-induced ARDS patients: a successful phase 1, control-placebo group, clinical trial
BackgroundAcute respiratory distress syndrome (ARDS) is the devastating complication of the new COVID-19 pandemic, directly correlated with releasing...
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Human Dental Pulp Stem Cells (DPSCs) Therapy in Rescuing Photoreceptors and Establishing a Sodium Iodate-Induced Retinal Degeneration Rat Model
BACKGROUND:Different methods have been used to inject stem cells into the eye for research. We previously explored the intravitreal route. Here, we...
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Brain interstitial fluid drainage and extracellular space affected by inhalational isoflurane: in comparison with intravenous sedative dexmedetomidine and pentobarbital sodium
Brain interstitial fluid drainage and extracellular space are closely related to waste clearance from the brain. Different anesthetics may cause...
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Experimental and spontaneous metastasis assays can result in divergence in clonal architecture
Intratumoural heterogeneity is associated with poor outcomes in breast cancer. To understand how malignant clones survive and grow in metastatic...
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Evaluation of different supportive treatments during packed cell volume replacement in calves naturally infected with tick fever agents
This study evaluated the effect of different supportive treatments on PCV replacement of dairy calves naturally infected with tick fever (TF) agents,...
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Adeno-associated virus-based caveolin-1 delivery via different routes for the prevention of cholesterol gallstone formation
BackgroundHepatic caveolin-1 (CAV1) is reduced in cholesterol gallstone disease (CGD). Mice with CAV1 deficiency were prone to develop CGD. However,...
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Standard toxicity study of clinical-grade allogeneic human bone marrow-derived clonal mesenchymal stromal cells
IntroductionMesenchymal stromal cells (MSCs) have opened a new window to treat inflammatory and non-inflammatory diseases. Nonetheless, their...
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Perfusion
There are three different ways to administer a drug to an organ: direct injection, surface application, and an indirect method. The indirect method...
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Skin Drug Administration
The structure of the mouse’s skin is very different from humans; hence, the injection techniques are quite different. Unfortunately, most laboratory...