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Regulation of Gene Expression Using dCas9-SunTag Platforms
Regulating gene expression is important for basic research and therapeutic applications. The epigenome is a record of genetic modifications such as...
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Revisiting genetic artifacts on DNA methylation microarrays exposes novel biological implications
BackgroundIllumina DNA methylation microarrays enable epigenome-wide analysis vastly used for the discovery of novel DNA methylation variation in...
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Determination of Migration Routes and Areas of Summer Vagrancy of Greater Spotted Eagles (Clanga clanga, Accipitriformes, Accipitridae) in the First Year of Their Life Using GPS–GSM Telemetry
AbstractFor young greater spotted eagles ( Clanga clanga ) tagged in the center of European Russia (four individuals) and in the Republic of Tatarstan...
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LncRNAs in neuropsychiatric disorders and computational insights for their prediction
Long non-coding RNAs (lncRNAs) are 200 nucleotide extended transcripts that do not encode proteins or possess limited coding ability. LncRNAs...
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DNA methylation in poultry: a review
As an important epigenetic modification, DNA methylation is involved in many biological processes such as animal cell differentiation, embryonic...
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Epigenetic Control of Diatom Genomes: An Overview from In Silico Characterization to Functional Studies
Epigenetics and its role in genome regulation is one of the most exciting areas of modern science. After a brief history of epigenetics and an...
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Transcription regulation by long non-coding RNAs: mechanisms and disease relevance
Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions remain largely unknown. In this Review, we discuss the...
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The role of long non-coding RNA H19 in infertility
Infertility is defined as the failure to conceive after at least one year of unprotected intercourse. Long non-coding RNAs (lncRNAs) are transcripts...
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The long non-coding RNA Kcnq1ot1 controls maternal p57 expression in muscle cells by promoting H3K27me3 accumulation to an intragenic MyoD-binding region
BackgroundThe cell-cycle inhibitor p57 kip2 plays a critical role in mammalian development by coordinating cell proliferation and differentiation in...
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Distinctive aspects of the placental epigenome and theories as to how they arise
The placenta has a methylome dramatically unlike that of any somatic cell type. Among other distinctions, it features low global DNA methylation,...
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Humangenetik
Die Humangenetik untersucht menschliche Erbkrankheiten. Mendelnde Merkmale kann man anhand von Stammbäumen analysieren. Verschiedene Phänomene wie...
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Magnetic maps in animal navigation
In addition to providing animals with a source of directional or ‘compass’ information, Earth’s magnetic field also provides a potential source of...
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Transgenerational inheritance of adrenal steroidogenesis inhibition induced by prenatal dexamethasone exposure and its intrauterine mechanism
BackgroundAdrenal gland is the synthesis and secretion organ of glucocorticoid, which is crucial to fetal development and postnatal fate. Recently,...
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Super-sectioning with multi-sheet reversible saturable optical fluorescence transitions (RESOLFT) microscopy
Light-sheet fluorescence microscopy is an invaluable tool for four-dimensional biological imaging of multicellular systems due to the rapid...
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Regulation der Genexpression bei Eukaryoten
Im Vergleich zur Genexpression bei Prokaryoten verläuft die eukaryotische Regulation erheblich feiner und abgestufter. Globingene veranschaulichen...
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The L1-dependant and Pol III transcribed Alu retrotransposon, from its discovery to innate immunity
The 300 bp dimeric repeats digestible by Alu I were discovered in 1979. Since then, Alu were involved in the most fundamental epigenetic mechanisms,...
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Fate-Map** Macrophages: From Ontogeny to Functions
Macrophages are vital to the physiological function of most tissues, but also contribute to disease through a multitude of pathological roles. They...
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DAMEfinder: a method to detect differential allele-specific methylation
BackgroundDNA methylation is a highly studied epigenetic signature that is associated with regulation of gene expression, whereby genes with high...
