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Mechano-inhibition of endocytosis sensitizes cancer cells to Fas-induced Apoptosis
The transmembrane death receptor Fas transduces apoptotic signals upon binding its ligand, FasL. Although Fas is highly expressed in cancer cells,...
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α-Actinin-4-Dependent Regulation of DNA Break Repair Is Not Dependent on NF-kB Activity
Abstractα-Actinin-4 is an actin-binding protein involved in a wide range of cellular processes. Along with actin and other proteins of the actin...
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Disturbance cues facilitate associative learning of predators in a coral reef fish
AbstractAquatic prey can gauge predation risk using chemical information, including chemical alarm cues — released when prey are injured, disturbance...
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Evidence of successive negative contrast in terrestrial toads (Rhinella arenarum): central or peripheral effect?
Prior research with terrestrial toads ( Rhinella arenarum ) in a water-reinforced instrumental situation indicated a direct relationship between...
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Biochemical Assays to Directly Assess Smoothened Activation by a Conformationally Sensitive Nanobody
The Hedgehog signaling pathway coordinates early development and is important in various cancers. Classic approaches to test pathway activation rely...
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The Imaging Flow Cytometry-Based Cytokinesis-Block MicroNucleus (CBMN) Assay
The dose of ionizing radiation received by an individual can be determined using biodosimetry methods which measure biomarkers of exposure in tissue...
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Heme oxygenase-1 mediates the inhibitory effect of ginseng (Panax ginseng) leaf extract on differentiation in 3T3-L1 adipocytes
BackgroundObesity, which is defined as the excess accumulation of body fat, poses metabolic diseases that result in significant health risks. Since...
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Green approach for the synthesis of ZnO nanoparticles using Cymbopogon citratus aqueous leaf extract: characterization and evaluation of their biological activities
BackgroundThe green synthesis of metal and metal oxide nanoparticles (NPs), notably from plants, has attracted increasing attention in recent years....
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Molecular Chaperone Receptors: An Update
Extracellular heat shock proteins (HSP) play important roles in cell signaling and immunity. Many of these effects are mediated by surface receptors...
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Aqp4a and Trpv4 mediate regulatory cell volume increase for swimming maintenance of marine fish spermatozoa
Volume regulation is essential for cell homeostasis and physiological function. Amongst the sensory molecules that have been associated with volume...
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A New Methanogenic, Hydrogenotrophic Archaeon from Spitsbergen Permafrost
AbstractA new strain of methanogenic archaea, designated VT T , was isolated from a sample of Spitsbergen permafrost. The cells were nonmotile curved...
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Chloride Channel-3 (ClC-3) Modifies the Trafficking of Leucine-Rich Repeat-Containing 8A (LRRC8A) Anion Channels
Chloride channel-3 (ClC-3) Cl − /H + antiporters and leucine-rich repeat-containing 8 (LRRC8) family anion channels have both been associated with...
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Decellularized Human Adipose Tissue as an Alternative Graft Material for Bone Regeneration
BACKGROUND: Tissue engineering approaches to treat damaged bone include various tissue transplants such as autologous, allogeneic, and xenografts....
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Advancement of Radiolabeled Exosomes in Brain Disorders
A groundbreaking nanotechnology is promised by the exosome application in brain disorder treatments due to its phenomenal characteristic of being...
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Hydrogenotrophic methanogen strain of Methanospirillum from anaerobic digester fed with agro-industrial waste
A hydrogenotrophic, mesophilic methanogen designated as strain T 5 3BJ was isolated from anaerobic digester continuously fed with agro-industrial...
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Decellularized cryopreserved human pericardium: a validation study towards tissue bank practice
Pericardial patches are currently used as reconstructive material in cardiac surgery for surgical treatment of cardiac septal defects. Autologous...
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BRET Sensors for Imaging Membrane Integrity of Microfluidically Generated Extracellular Vesicles
Extracellular vesicles (EVs) derived from various cell lines have been extensively used as natural nanodelivery vehicles for drug, protein, and...
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Mechanically-Evoked TRPV4-Mediated Currents Are Modulated by Activated Integrin β1
TRPV4 is a polymodal, non-selective cation channel which can be activated by mechanical stimuli only when they are applied directly at the...
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Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins
Lysosomal membrane permeabilization (LMP) and cathepsin release typifies lysosome-dependent cell death (LDCD). However, LMP occurs in most regulated...
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Anti-Osteoarthritic Effects of Cartilage-Derived Extracellular Matrix in a Rat Osteoarthritis Model
BACKGROUND: The extracellular matrix (ECM) has many functions, such as segregating tissues, providing support, and regulating intercellular...
