Search
Search Results
-
Gene expression variability across cells and species shapes the relationship between renal resident macrophages and infiltrated macrophages
BackgroundTwo main subclasses of macrophages are found in almost all solid tissues: embryo-derived resident tissue macrophages and bone...
-
Histone H3K36me2 demethylase KDM2A promotes bladder cancer progression through epigenetically silencing RARRES3
Epigenetic dysregulation contributes to bladder cancer tumorigenesis. H3K36me2 demethylase KDM2A functions as an important epigenetic regulator of...
-
Echocardiographic assessment of Xenopus tropicalis heart regeneration
BackgroundRecently, it was reported that the adult X. tropicalis heart can regenerate in a nearly scar-free manner after injury via apical...
-
miR-485-3p and miR-4728-5p as Tumor Suppressors in Pathogenesis of Colorectal Cancer
AbstractMicroRNAs (miRNAs) are a class of small noncoding RNAs that have major functions in the development and progression of colorectal cancer...
-
LINC01119 negatively regulates osteogenic differentiation of mesenchymal stem cells via the Wnt pathway by targeting FZD4
BackgroundMesenchymal stem cells (MSCs) can differentiate into diverse cell types under specific conditions. Dysfunction in the osteogenic...
-
SOX9 in organogenesis: shared and unique transcriptional functions
The transcription factor SOX9 is essential for the development of multiple organs including bone, testis, heart, lung, pancreas, intestine and...
-
Search and comparison of (epi)genomic feature patterns in multiple genome browser tracks
BackgroundGenome browsers are widely used for locating interesting genomic regions, but their interactive use is obviously limited to inspecting...
-
eIF3b regulates the cell proliferation and apoptosis processes in chronic myelogenous leukemia cell lines via regulating the expression of C3G
ObjectiveTo investigate the functions of eIF3b in chronic myelogenous leukemia (CML).
MethodsThe expression of eIF3b was inhibited by transfecting...
-
APEX1 Nuclease and Redox Functions are Both Essential for Adult Mouse Hematopoietic Stem and Progenitor Cells
Self-renewal and differentiation of hematopoietic stem and progenitor cells (HSPCs) are carefully controlled by extrinsic and intrinsic factors, to...
-
c-Jun as a one-way valve at the naive to primed interface
Backgroundc-Jun is a proto-oncogene functioning as a transcription factor to activate gene expression under many physiological and pathological...
-
A Unified Genomic Mechanism of Cell-Fate Change
The purpose of our studies is to elucidate the nature of massive control of the whole genome expression with a particular emphasis on cell-fate...
-
Application of network pharmacology and molecular docking to elucidate the potential mechanism of Eucommia ulmoides-Radix Achyranthis Bidentatae against osteoarthritis
BackgroundOsteoarthritis is a disabling disease, which seriously affects the quality of life of patients. Increasing evidence has indicated that...
-
Tyrosine kinase SRC-induced YAP1-KLF5 module regulates cancer stemness and metastasis in triple-negative breast cancer
SRC is the first identified oncogene, and its aberrant activation has been implicated as a driving event in tumor initiation and progression....
-
-
Transcriptomic analysis of glucosidase II beta subunit (GluIIß) knockout A549 cells reveals its roles in regulation of cell adhesion molecules (CAMs) and anti-tumor immunity
Glucosidase II beta subunit (GluIIß), encoded from PRKCSH , is a subunit of the glucosidase II enzyme responsible for quality control of N-linked...
-
The inflammatory signature in monocytes of Sjögren’s syndrome and systemic lupus erythematosus, revealed by the integrated Reactome and drug target analysis
BackgroundThe innate immune regulation, especially by the type I IFN signature in the CD14+ monocytes, is known to be critical in the pathogenesis of...
-
Single-cell characterization of self-renewing primary trophoblast organoids as modeling of EVT differentiation and interactions with decidual natural killer cells
BackgroundExtravillous trophoblast cell (EVT) differentiation and its communication with maternal decidua especially the leading immune cell type...
-
Network analysis uncovers putative genes affecting resistance to tick infestation in Braford cattle skin
BackgroundGenetic resistance in cattle is considered a suitable way to control tick burden and its consequent losses for livestock production....
-
Genome-wide identification of enhancers and transcription factors regulating the myogenic differentiation of bovine satellite cells
BackgroundSatellite cells are the myogenic precursor cells in adult skeletal muscle. The objective of this study was to identify enhancers and...
-
FOXM1 is critical for the fitness recovery of chromosomally unstable cells
AbstractTumor progression and evolution are frequently associated with chromosomal instability (CIN). Tumor cells often express high levels of the...
