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A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation
Mitochondria are the main site for generating reactive oxygen species, which are key players in diverse biological processes. However, the molecular...
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Bear trade in the Czech Republic: an analysis of legal and illegal international trade from 2005 to 2020
There is a large demand for bear parts in the Czech Republic, and this drives legal and illegal trade in various bear species sourced from outside...
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Ruthenium (II)/allopurinol complex inhibits breast cancer progression via multiple targets
AbstractMetal complexes based on ruthenium have established excellent activity with less toxicity and great selectivity for tumor cells. This study...
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Rice Carbohydrate-Binding Malectin-Like Protein, OsCBM1, Contributes to Drought-Stress Tolerance by Participating in NADPH Oxidase-Mediated ROS Production
Carbohydrate-binding malectin/malectin-like domain-containing proteins (CBMs) are a recently identified protein subfamily of lectins that...
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The Next Generation of Therapeutic Radionuclides
A wide variety of radionuclides beyond the handful that are routinely used in nuclear medicine are suitable—and even desirable—for biomedical...
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Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities
As coronavirus disease 2019 (COVID-19) threatens human health globally, infectious disorders have become one of the most challenging problem for the...
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What Has Theory and Crystallography Revealed About the Mechanism of Catalysis by Orotidine Monophosphate Decarboxylase?
In 1995, Wolfenden and Radzicka showed that orotidine 5′-monophosphate decarboxylase (ODCase) was the most proficient enzyme. Since then, the...
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Multi-elemental Characterization of Semolina Samples by Inductively Coupled Plasma-Tandem Mass Spectrometry (ICP-MS/MS)
The precise characterization of the elemental composition of cereals and cereal products is becoming crucial to assess their nutritional values,...
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LPS-related muscle loss is associated with the alteration of Bacteroidetes abundance, systemic inflammation, and mitochondrial morphology in a weaned piglet model
We previously demonstrated that lipopolysaccharide (LPS) injection-induced immune stress could impair muscle growth in weaned piglets, but the...
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Control of acute myeloid leukemia by a trifunctional NKp46-CD16a-NK cell engager targeting CD123
CD123, the alpha chain of the IL-3 receptor, is an attractive target for acute myeloid leukemia (AML) treatment. However, cytotoxic antibodies or T...
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Fortilin interacts with TGF-β1 and prevents TGF-β receptor activation
Fortilin is a 172-amino acid multifunctional protein present in both intra- and extracellular spaces. Although fortilin binds and regulates various...
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Metabolic and epigenetic regulation of T-cell exhaustion
Current immunotherapies yield remarkable clinical outcomes by boosting the power of host immunity in cancer cell elimination and viral clearance....
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TatD DNases of African trypanosomes confer resistance to host neutrophil extracellular traps
African trypanosomatid parasites escape host acquired immune responses through periodic antigenic variation of their surface coat. In this study, we...
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Biotransformation of bisphenol F by white-rot fungus Phanerochaete sordida YK-624 under non-ligninolytic condition
AbstractEnvironmental bisphenol F (BPF) has a cyclic endocrine disruption effect, seriously threatening animal and human health. It is frequently...
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Integrated neural tracing and in-situ barcoded sequencing reveals the logic of SCN efferent circuits in regulating circadian behaviors
The circadian clock coordinates rhythms in numerous physiological processes to maintain organismal homeostasis. Since the suprachiasmatic nucleus...
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Aldo-keto reductase family 1 member A1 (AKR1A1) exerts a protective function in alcohol-associated liver disease by reducing 4-HNE accumulation and p53 activation
BackgroundThe development of alcohol-associated liver disease (ALD) is influenced by the amount and duration of alcohol consumption. The resulting...
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The Role of Interactions Between Organic and Conventional Farming in the Ecological Transition of a Territorial Food System
The territorial scale is increasingly being recognised as appropriate for addressing the ecological transition of food systems, both at the...
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Expression of phenylalanine ammonia lyase as an intracellularly free and extracellularly cell surface-immobilized enzyme on a gut microbe as a live biotherapeutic for phenylketonuria
Phenylketonuria (PKU), a disease resulting in the disability to degrade phenylalanine (Phe) is an inborn error with a 1 in 10,000 morbidity rate on...
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An atlas of CNV maps in cattle, goat and sheep
Copy number variation (CNV) is the most prevalent type of genetic structural variation that has been recognized as an important source of phenotypic...