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Pulmonary Vascular Remodeling by Resident Lung Stem and Progenitor Cells
Tissue-resident stem and progenitor cells are important regulators of tissue homeostasis, repair or regeneration as well as remodeling. While...
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Regular heartbeat rhythm at the heartbeat initiation stage is essential for normal cardiogenesis at low temperature
BackgroundThe development of blood flow in the heart is crucial for heart function and embryonic survival. Recent studies have revealed the...
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Molecular mechanisms of epithelial–mesenchymal transition
The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as epithelial–mesenchymal transition (EMT), is integral...
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Loss of muscleblind-like 1 promotes invasive mesenchyme formation in endocardial cushions by stimulating autocrine TGFβ3
BackgroundValvulogenesis and septation in the develo** heart depend on the formation and remodeling of endocardial cushions in the atrioventricular...
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Principal component analysis-based unsupervised feature extraction applied to in silico drug discovery for posttraumatic stress disorder-mediated heart disease
BackgroundFeature extraction (FE) is difficult, particularly if there are more features than samples, as small sample numbers often result in biased...
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Polymorphisms of VEGF, TGFβ1, TGFβR2 and conotruncal heart defects in a Chinese population
Genetic variants may determine susceptibility of congenital heart disease (CHD). To evaluate the impact of transforming growth factor-β1 (TGFβ1),...
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Fibulin-2 is involved in early extracellular matrix development of the outgrowing mouse mammary epithelium
Cell–matrix interactions control outgrowth of mammary epithelium during puberty and pregnancy. We demonstrate here that the glycoprotein fibulin-2...
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Multiple modes of proepicardial cell migration require heartbeat
BackgroundThe outermost layer of the vertebrate heart, the epicardium, forms from a cluster of progenitor cells termed the proepicardium (PE). PE...
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Targeted Editing of Therapeutic Genes Using DNA-Based Transcriptional Activators: Scope and Challenges
In recent years, there has been an increasing interest among the clinicians to devise genetic knowledge-based therapeutic strategies to treat complex...
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Co-ordinating Notch, BMP, and TGF-β signaling during heart valve development
Congenital heart defects affect approximately 1–5 % of human newborns each year, and of these cardiac defects 20–30 % are due to heart valve...
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Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation
A key step in heart development is the coordinated development of the atrioventricular canal (AVC), the constriction between the atria and ventricles...
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Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries
Coronary arteries bring blood flow to the heart muscle. Understanding the developmental program of the coronary arteries provides insights into the...
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Multiple essential roles for primary cilia in heart development
BackgroundThe primary cilium is a microtubule-based, plasma membrane-ensheathed protrusion projecting from the basal bodies of almost all cell types...
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Tissue Distribution of Connexins
There are more than 20 known connexin proteins identified in the human and mice genome. However, not all the 20 connexins are expressed in all the...
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Notch signalling in cardiovasculogenesis: insight into their role in early cardiovascular development
The role of Notch signalling in congenital cardiovascular disease is evident by the identification of human mutations in several Notch signalling...
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Of mice and men: molecular genetics of congenital heart disease
Congenital heart disease (CHD) affects nearly 1 % of the population. It is a complex disease, which may be caused by multiple genetic and...
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WIF1 causes dysfunction of heart in transgenic mice
Wnt activity is a key regulator of cardiac progenitor cell self-renewal, differentiation and morphogenesis. However, Wnt inhibitory factor 1 (WIF1),...
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TGF-β and Cardiovascular Disorders
Transforming growth factor β (TGF-β) is a secreted pleiotropic cytokine that is involved in a wide range of biological processes and has essential...
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Distinct Signaling Pathways Activated by “Extracellular” and “Intracellular” Serotonin in Heart Valve Development and Disease
Cardiac valve diseases are often due to developmental anomalies that progressively lead to the abnormal distribution and organization of...
