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Xrcc5/Ku80 is required for the repair of DNA damage in fully grown meiotically arrested mammalian oocytes
Mammalian oocytes spend most of their life in a unique state of cell cycle arrest at meiotic prophase I, during which time they are exposed to...
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MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC
BackgroundAlthough the clinical application of PARP inhibitors has brought hope to ovarian cancer, the problem of its resistance has become...
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Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization
Nuclear actin-based movements have been shown to orchestrate clustering of DNA double-strand breaks (DSBs) into homology-directed repair domains....
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Syntaxin 18 regulates the DNA damage response and epithelial-to-mesenchymal transition to promote radiation resistance of lung cancer
Radiotherapy is an important modality in lung cancer treatment. Despite advances in treatment planning and dose delivery, patient benefit is still...
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Repression of p53 function by SIRT5-mediated desuccinylation at Lysine 120 in response to DNA damage
p53 is a classic tumor suppressor that functions in maintaining genome stability by inducing either cell arrest for damage repair or cell apoptosis...
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A protein with broad functions: damage-specific DNA-binding protein 2
Damage-specific DNA-binding protein 2 (DDB2) was initially identified as a component of the damage-specific DNA-binding heterodimeric complex, which...
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Accumulation of DNA damage alters microRNA gene transcription in Arabidopsis thaliana
BackgroundMicroRNAs (miRNAs) and other epigenetic modifications play fundamental roles in all eukaryotic biological processes. DNA damage repair is a...
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PLK1 inhibition promotes apoptosis and DNA damage in glioma stem cells by regulating the nuclear translocation of YBX1
Glioma stem cells (GSCs) are the important cause of tumorigenesis, recurrence, and chemo(radio)resistance in glioma. Targeting GSCs helps improve the...
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YAP nuclear translocation induced by HIF-1α prevents DNA damage under hypoxic conditions
Maladaptive repair of acute kidney injury (AKI) is associated with a high risk of develo** chronic kidney disease deemed irremediable even in...
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Cooperative effects of RIG-I-like receptor signaling and IRF1 on DNA damage-induced cell death
Properly responding to DNA damage is vital for eukaryotic cells, including the induction of DNA repair, growth arrest and, as a last resort to...
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Synergistic Effect of Maternal Micronutrient Supplementation on ORFV DNA Vaccine Immune Response in a Pregnant Model
Contagious ecthyma is a contagious zoonotic disease caused by the Orf virus that can infect farm animals and humans, but no vaccine is available for...
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Studying Translesion DNA Synthesis Using Xenopus In Vitro Systems
Cell-free extracts derived from Xenopus eggs have been widely used to decipher molecular pathways involved in several cellular processes including...
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Analyzing the Effects of HDAC Inhibitors on DNA Damage and Associated Cytotoxicity in Primary Hepatocytes
Primary hepatocytes are the gold standard in pharmaco- and toxicokinetic studies during preclinical development of drug candidates. Such cells are a...
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Global DNA methylation profile at LINE-1 repeats and promoter methylation of genes involved in DNA damage response and repair pathways in human peripheral blood mononuclear cells in response to γ-radiation
DNA methylation is an epigenetic mechanism, which plays an important role in gene regulation. The present study evaluated DNA methylation profile of...
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DNA replication and replication stress response in the context of nuclear architecture
The DNA replication process needs to be coordinated with other DNA metabolism transactions and must eventually extend to the full genome, regardless...
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Wee1 promotes cell proliferation and imatinib resistance in chronic myeloid leukemia via regulating DNA damage repair dependent on ATM-γH2AX-MDC1
BackgroundThe treatment of chronic myeloid leukemia (CML) is facing the dilemma of tyrosine kinase inhibitors (TKIs) resistance and disease...
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Analyses of oxidative DNA damage among coal vendors via single cell gel electrophoresis and quantification of 8-hydroxy-2’-deoxyguanosine
Looking at the development status of Nigeria and other develo** nations, most low-income and rural households often use coal as a source of energy...
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Werner helicase is required for proliferation and DNA damage repair in multiple myeloma
BackgroundMultiple myeloma (MM), characterized by extensive genomic instability and aberrant DNA damage repair, is a plasma cell malignancy due to...
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Exogenous Glutathione Enhances Salt Tolerance in Kenaf by Mediating Modulation of Oxidative Stress Response and DNA Methylation
Kenaf ( Hibiscus cannabinus L.) is an important fiber crop, which can be applied for the restoration of saline-alkali land. The objective of our study...
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DNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0
Paraspeckles are mammal-specific membraneless nuclear bodies that participate in various biological processes. NONO, a central paraspeckle component,...
