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Timekee** in the hindbrain: a multi-oscillatory circadian centre in the mouse dorsal vagal complex
Metabolic and cardiovascular processes controlled by the hindbrain exhibit 24 h rhythms, but the extent to which the hindbrain possesses endogenous...
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Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis
The functions of Sertoli cells in spermatogenesis have attracted much more attention recently. Normal spermatogenesis depends on Sertoli cells,...
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Long-Term Maintenance of the Functional Changes Induced by Influenza A Virus and/or LPS in Human Endothelial ECV-304 Cell Sublines
AbstractInfluenza A virus and secondary bacterial infection may have remote effects in the form of cardiovascular complications or fibrosis in...
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Disease-associated mutations of claudin-19 disrupt retinal neurogenesis and visual function
Mutations of claudin-19 cause Familial Hypomagnesaemia and Hypercalciuria, Nephrocalcinosis with Ocular Involvement. To study the ocular disease...
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Identification of serotonin 2A receptor as a novel HCV entry factor by a chemical biology strategy
Hepatitis C virus (HCV) is a leading cause of liver disease worldwide. Although several HCV protease/polymerase inhibitors were recently approved by...
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Mycotoxin binder improves growth rate in piglets associated with reduction of toll-like receptor-4 and increase of tight junction protein gene expression in gut mucosa
BackgroundDeoxynivalenol (DON) is a mycotoxin produced by Fusarium species in the field, commonly found in cereal grains, which negatively affects...
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The distinct role of strand-specific miR-514b-3p and miR-514b-5p in colorectal cancer metastasis
The abnormal expression of microRNAs (miRNAs) in colorectal cancer (CRC) progression has been widely investigated. It was reported that the same...
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Tubuloids derived from human adult kidney and urine for personalized disease modeling
Adult stem cell-derived organoids are three-dimensional epithelial structures that recapitulate fundamental aspects of their organ of origin. We...
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Alterations in the diversity and composition of mice gut microbiota by lytic or temperate gut phage treatment
Phages, the most abundant species in the mammalian gut, have numerous advantages as biocontrol agent over antibiotics. In this study, mice were...
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Effect of Zinc Supplementation on Growth Performance, Intestinal Development, and Intestinal Barrier-Related Gene Expression in Pekin Ducks
The current study was conducted to investigate the effect of zinc supplementation on the growth performance, intestinal morphology, and the...
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Transcriptome analysis reveals regional and temporal differences in mucosal immune system development in the small intestine of neonatal calves
BackgroundPostnatal development of the mammalian mucosal immune system is crucial for responding to the rapid colonization by commensal bacteria and...
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Dietary salt loading and ion-poor water exposure provide insight into the molecular physiology of the rainbow trout gill epithelium tight junction complex
This study utilized dietary salt loading and ion-poor water (IPW) exposure of rainbow trout ( Oncorhynchus mykiss ) to further understand the role of...
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Function and Characterization of Cellular Membranes
The eukaryotic cells are structurally more complex than the prokaryotic cells. The eukaryotic cells, apart from a plasma membrane that encloses the...
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The response of claudin-like transmembrane septate junction proteins to altered environmental ion levels in the larval mosquito Aedes aegypti
Septate junctions (SJs) occlude the paracellular pathway and function as paracellular diffusion barriers within invertebrate epithelia. However,...
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Interferon-gamma increased epithelial barrier function via upregulating claudin-7 expression in human submandibular gland duct epithelium
Tight junctions (TJs) are necessary for salivary gland function and may serve as indicators of salivary gland epithelial dysfunction. IgG4-related...
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Molecular basis of claudin-17 anion selectivity
Claudin-17 is a paracellular channel-forming tight junction protein. Unlike the cation channels claudin-2 and -15, claudin-17 forms a distinct...
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Biology of the Sertoli Cell in the Fetal, Pubertal, and Adult Mammalian Testis
A healthy man typically produces between 50 × 106 and 200 × 106 spermatozoa per day by spermatogenesis; in the absence of Sertoli cells in the male...
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Irsogladine Maleate Regulates Gap Junctional Intercellular Communication-Dependent Epithelial Barrier in Human Nasal Epithelial Cells
The airway epithelium of the human nasal mucosa acts as the first physical barrier that protects against inhaled substances and pathogens....
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The potential effects of antioxidant feed additives in mitigating the adverse effects of corn naturally contaminated with Fusarium mycotoxins on antioxidant systems in the intestinal mucosa, plasma, and liver in weaned pigs
Seventy-two piglets (6.0 kg BW) were randomly distributed within six different dietary treatments to evaluate the effect of deoxynivalenol (DON) and...
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Gene expression and functional annotation of human choroid plexus epithelium failure in Alzheimer’s disease
BackgroundAlzheimer’s disease (AD) is the most common form of dementia. AD has a multifactorial disease etiology and is currently untreatable....
