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An updated review on the role of the CXCL8-CXCR1/2 axis in the progression and metastasis of breast cancer
Chronic inflammation is a major factor in tumor growth and progression. Cancer cells secrete C-X-C chemokine ligand 8 (CXCL8) along with its receptor...
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α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway
Cognitive dysfunction and dementia are critical symptoms of Lewy Body dementias (LBD). Specifically, alpha-synuclein (αSyn) accumulation in the...
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Lipid nanoparticle technologies for the study of G protein-coupled receptors in lipid environments
G protein-coupled receptors (GPCRs) are a large family of integral membrane proteins which conduct a wide range of biological roles and represent...
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In vitro estimation of metal-induced disturbance in chicken gut-oviduct chemokine circuit
BackgroundsHeavy metals affect various processes in the embryonic development. Embryonic fibroblasts (EFs) play key roles in the innate recognition...
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CXCR1 drives the pathogenesis of EAE and ARDS via boosting dendritic cells-dependent inflammation
Chemokines secreted by dendritic cells (DCs) play a key role in the regulation of inflammation and autoimmunity through chemokine receptors. However,...
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Interaction networks and pathway analysis of genetic resistance to gastrointestinal nematodes in sheep
Gastrointestinal nematode (GINs) infections are one of the causative agents of health and economic issues in sheep production systems worldwide....
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Case Study #5: CXCR4-Targeted Radiotherapeutics
Radiopharmaceutical therapy (RPT) has become a mainstay of modern oncology but remains limited to solid tumors, including orphan diseases such as...
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The marriage of chemokines and galectins as functional heterodimers
Trafficking of leukocytes and their local activity profile are of pivotal importance for many (patho)physiological processes. Fittingly,...
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Dynamic Changes in Circulatory Cytokines and Chemokines Levels in Mild to Severe COVID-19 Patients
Immune dysregulation is a key feature of the coronavirus disease-2019 (COVID-19). However, disparities in responses across ethnic groups are...
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Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma
For head and neck squamous cell carcinoma (HNSCC), the local invasion and distant metastasis represent the predominant causes of mortality. Targeted...
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Homology Modeling of Class A G-Protein-Coupled Receptors in the Age of the Structure Boom
With 700 members, G protein-coupled receptors (GPCRs) of the rhodopsin family (class A) form the largest membrane receptor family in humans and are...
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Cancer associated fibroblast–derived CCL5 promotes hepatocellular carcinoma metastasis through activating HIF1α/ZEB1 axis
Cancer-associated fibroblasts (CAFs) are one of the most enriched components of Hepatocellular carcinoma (HCC) microenvironment, which are tightly...
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Long noncoding RNAs and mRNAs profiling in ovary during laying and broodiness in Taihe Black-Bone Silky Fowls (Gallus gallus Domesticus Brisson)
BackgroundBroodiness significantly impacts poultry egg production, particularly notable in specific breeds such as the black-boned Silky,...
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Breast Tumor Targeting in Mice Bearing 4T1 Tumor with Labeled CXCR4 Antagonist Analogue
Chemokine receptor belongs to G-protein-coupled cell-surface receptors. CXCR4 as a chemokine receptor is over-expressed in many type of solid tumors...
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Fish TNF and TNF receptors
Tumor necrosis factors (TNFs) are a group of cytokines that play critical roles in regulating a diverse range of physiological processes in...
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Comparative genomics and integrated system biology approach unveiled undirected phylogeny patterns, mutational hotspots, functional patterns, and molecule repurposing for monkeypox virus
Monkeypox is a viral zoonosis with symptoms that are reminiscent of those experienced in previous smallpox cases. The GSAID database (Global...
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Detailed role of SR-A1 and SR-E3 in tumor biology, progression, and therapy
The first host defense systems are the innate immune response and the inflammatory response. Among innate immune cells, macrophages, are crucial...
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The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus
The endogenous chemokines CCL19 and CCL21 signal via their common receptor CCR7. CCL21 is the main lymph node homing chemokine, but a weak...
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Macrophages communicate with mesangial cells through the CXCL12/DPP4 axis in lupus nephritis pathogenesis
Lupus nephritis (LN) occurs in 50% of cases of systemic lupus erythematosus (SLE) and is one of the most serious complications that can occur during...
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The Serum Level of CXCL9, CXCL10, and CXCL11 and the Expression of CXCR3 of Peripheral Blood Mononuclear Cells in Brucellosis Patients
Brucella spp. can replicate in human endothelial cells, inducing an inflammatory response with increased expression of chemokines. Although Brucella ...
