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Molecular explanation of Wnt/βcatenin antagonist pyrvinium mediated calcium equilibrium changes in aging cardiovascular disorders
The symptoms of ageing are somewhat different and can lead to the altered role of the cardiovascular system at the levels of genetic, biochemical,...
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Role of the Ror family receptors in Wnt5a signaling
Ror-family receptors, Ror1 and Ror2, are type I transmembrane proteins that possess an extracellular cysteine-rich domain, which is conserved...
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Construction of an Ultra-Large Phage Display Library by Kunkel Mutagenesis and Rolling Circle Amplification
An important contributor to the successful generation of recombinant affinity reagents via phage display is a large and diverse library. We describe,...
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ASF1 regulates asexual and sexual reproduction in Stemphylium eturmiunum by DJ-1 stimulation of the PI3K/AKT signaling pathway
Most fungi display a mixed mating system with both asexual and sexual reproduction. The timing of the two modes of reproduction must be carefully...
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Time-dependent antagonist-agonist switching in receptor tyrosine kinase-mediated signaling
BackgroundErbB4/HER4 is a unique member of the ErbB family of receptor tyrosine kinases concerning its activation of anti-proliferative JAK2-STAT5...
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Comparative analysis of the kinomes of Plasmodium falciparum, Plasmodium vivax and their host Homo sapiens
BackgroundNovel antimalarials should be effective across all species of malaria parasites that infect humans, especially the two species that bear...
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Genetic Studies on Behavior
Animal behavior is one of the most complex phenomena in biology. Understanding the cellular and molecular basis of behavior is one of the critical...
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Phosphorylation-dependent BRD4 dimerization and implications for therapeutic inhibition of BET family proteins
Bromodomain-containing protein 4 (BRD4) is an epigenetic reader and oncology drug target that regulates gene transcription through binding to...
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Promoters of Arabidopsis Casein kinase I-like 2 and 7 confer specific high-temperature response in anther
Key message(1) We systematically analyze the promoter activities of AtCKLs in various tissues; (2) AtCKL2 and AtCKL7 were expressed in early...
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5-Azacytidine affects gene expression and metabolic profile of Pinus elliottii x Pinus caribaea var. hondurensis embryogenic cell lines
The current study evaluated the effect of (i) genotypes on somatic embryogenesis initiation of Pinus elliottii x Pinus caribaea var. hondurensis and...
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CCDC28A deficiency causes sperm head defects, reduced sperm motility and male infertility in mice
Mature spermatozoa with normal morphology and motility are essential for male reproduction. The epididymis has an important role in the proper...
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High dietary wheat starch negatively regulated growth performance, glucose and lipid metabolisms, liver and intestinal health of juvenile largemouth bass, Micropterus salmoides
Largemouth bass ( Micropterus salmoides ) were fed with three diets containing 6%, 12%, and 18% wheat starch for 70 days to examine their impacts on...
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Analysis of state 1—state 2 transitions by genome editing and complementation reveals a quenching component independent from the formation of PSI-LHCI-LHCII supercomplex in Arabidopsis thaliana
BackgroundThe light-harvesting antennae of photosystem (PS) I and PSII are pigment-protein complexes responsible of the initial steps of sunlight...
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Energy deprivation-induced AMPK activation inhibits milk synthesis by targeting PrlR and PGC-1α
BackgroundThe mammary gland is responsible for milk production and secretion, which is critical for neonatal health during lactation. Lactation...
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Mechanical stretch leads to increased caveolin-1 content and mineralization potential in extracellular vesicles from vascular smooth muscle cells
BackgroundHypertension-induced mechanical stress on vascular smooth muscle cells (VSMCs) is a known risk factor for vascular remodeling, including...
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Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy
Platinum-based chemotherapy remains the cornerstone of treatment for most non-small cell lung cancer (NSCLC) cases either as maintenance therapy or...
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Chromatography
This chapter covers the principle, working, and operations of different types of chromatographic techniques like paper, thin layer, column...
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Beyond controlling cell size: functional analyses of S6K in tumorigenesis
As a substrate and major effector of the mammalian target of rapamycin complex 1 (mTORC1), the biological functions of ribosomal protein S6 kinase...
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Hippo signaling pathway and respiratory diseases
The hippo signaling pathway is a highly conserved evolutionary signaling pathway that plays an important role in regulating cell proliferation, organ...
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Melatonin/nicotinamide mononucleotide/ubiquinol: a cocktail providing superior cardioprotection against ischemia/reperfusion injury in a common co-morbidities modelled rat
BackgroundThe metabolic and intracellular abnormalities in aging and diabetes cause loss of cardioprotection by routine interventions against...
