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Circular RNAs and glioblastoma multiforme: focus on molecular mechanisms
Glioblastoma multiforme (GBM), as a deadly and almost incurable brain cancer, is the most invasive form of CNS tumors that affects both children and...
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The Regenerative Microenvironment of the Tissue Engineering for Urethral Strictures
Urethral stricture caused by various reasons has threatened the quality of life of patients for decades. Traditional reconstruction methods,...
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Wnt/β-catenin-driven EMT regulation in human cancers
Metastasis accounts for 90% of cancer-related deaths among the patients. The transformation of epithelial cells into mesenchymal cells with molecular...
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Examining Mechanisms for Voltage-Sensitive Calcium Channel-Mediated Secretion Events in Bone Cells
In addition to their well-described functions in cell excitability, voltage-sensitive calcium channels (VSCCs) serve a critical role in calcium (Ca 2+ )...
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Development of the Avian Respiratory System
Comprehensive systematic account of the development of the avian respiratory system, specifically that of the domestic fowl, Gallus gallus variant...
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YAP-dependent Wnt5a induction in hypertrophic adipocytes restrains adiposity
Wnt5a, a prototypic non-canonical Wnt, is an inflammatory factor elevated in the sera of obese humans and mice. In the present study, fat-specific...
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The compact genome of the sponge Oopsacas minuta (Hexactinellida) is lacking key metazoan core genes
BackgroundExplaining the emergence of the hallmarks of bilaterians is a central focus of evolutionary developmental biology—evodevo—and evolutionary...
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Role of microRNAs in epidermal growth factor receptor signaling pathway in cervical cancer
Cervical cancer is one of the most common disorders in females all around the world. Similar to other types of cancer, several signaling pathways are...
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Wnt signaling and Loxl2 promote aggressive osteosarcoma
Osteosarcoma (OS) is the most frequent primary malignant bone tumor in urgent need of better therapies. Using genetically modified mouse models...
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PFT-α protects the blood-brain barrier through the Wnt/β-catenin pathway after acute ischemic stroke
The dysfunction of blood-brain barrier (BBB) plays a pivotal role in brain injury and subsequent neurological deficits of ischemic stroke. The...
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Signaling pathways involved in colorectal cancer progression
Colorectal cancer (CRC) is the fourth leading cause of the worldwide cancer mortality. Different molecular mechanisms have been attributed to the...
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S100A16 promotes acute kidney injury by activating HRD1-induced ubiquitination and degradation of GSK3β and CK1α
The pathogenesis of acute kidney injury (AKI) is associated with the activation of multiple signaling pathways, including Wnt/β-catenin signaling....
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Mobilization and activation of tumor-infiltrating dendritic cells inhibits lymph node metastasis in intrahepatic cholangiocarcinoma
Lymph node metastasis (LNM) facilitates distant tumor colonization and leads to the high mortality in patients with intrahepatic cholangiocarcinoma...
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Merlin regulates signaling events at the nexus of development and cancer
BackgroundIn this review, we describe how the cytoskeletal protein Merlin, encoded by the Neurofibromin 2 ( NF2 ) gene, orchestrates developmental...
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Molecular pathways and therapeutic targets linked to triple-negative breast cancer (TNBC)
Cancer is a group of diseases characterized by uncontrolled cellular growth, abnormal morphology, and altered proliferation. Cancerous cells lose...
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Long noncoding RNA DLGAP1-AS2 facilitates Wnt1 transcription through physically interacting with Six3 and drives the malignancy of gastric cancer
The long noncoding RNA (lncRNA) DLGAP1-AS2 has recently been characterized as an oncogenic lncRNA in several cancers. However, its biological roles...
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YAP-mediated trophoblast dysfunction: the common pathway underlying pregnancy complications
Yes-associated protein (YAP) is a pivotal regulator in cellular proliferation, survival, differentiation, and migration, with significant roles in...
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Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation
The majorities of colorectal cancer (CRC) cases are sporadic in origin and a large proportion of etiologies are associated with environmental stress...
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Heterogeneous expression and role of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in small cell lung cancer
The present study investigated the expression and role of ROR2 in small cell lung cancer (SCLC). To examine the expression of ROR2, 27 surgically...
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Understanding autophagy role in cancer stem cell development
Cancer stem cells (CSCs) are a small subpopulation of immature cells located in the tumor mass. These cells are responsible for tumor development,...
