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Production of sesterterpene ophiobolin by a bifunctional terpene synthase in Escherichia coli
Ophiobolins (ophs) are characteristic 5-8-5 tricyclic sesterterpenes with potential pharmaceutical activities. Ophiobolin synthase is a bifunctional...
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Identification of the glutamine synthetase (GS) gene family in four wheat species and functional analysis of Ta4D.GSe in Arabidopsis thaliana
AbstractDrought stress can negatively impact crop yield and quality. Improving wheat yields under drought stress is a major objective of agronomic...
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The Mechanism of Inhibition of Mycobacterial (p)ppGpp Synthetases by a Synthetic Analog of Erogorgiaene
AbstractThe synthesis of (p)ppGpp alarmones plays a vital role in the regulation of metabolism suppression, growth rate control, virulence, bacterial...
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Targeted protein degradation: from mechanisms to clinic
Targeted protein degradation refers to the use of small molecules to induce the selective degradation of proteins. In its most common form, this...
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Nonribosomal peptide synthetase gene clusters and characteristics of predicted NRPS-dependent siderophore synthetases in Armillaria and other species in the Physalacriaceae
Fungal secondary metabolites are often pathogenicity or virulence factors synthesized by genes contained in secondary metabolite gene clusters...
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Characterization of the ADP-β-d-manno-heptose biosynthetic enzymes from two pathogenic Vibrio strains
AbstractADP-activated β - d - manno -heptoses (ADP- β - d - manno -heptoses) are precursors for the biosynthesis of the inner core of lipopolysaccharide in...
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Increased biosynthesis of acetyl-CoA in the yeast Saccharomyces cerevisiae by overexpression of a deregulated pantothenate kinase gene and engineering of the coenzyme A biosynthetic pathway
Coenzyme A (CoA) and its derivatives such as acetyl-CoA are essential metabolites for several biosynthetic reactions. In the yeast S. cerevisiae ,...
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Subtractive sequence analysis aided druggable targets mining in Burkholderia cepacia complex and finding inhibitors through bioinformatics approach
Burkholderia cepacia complex (BCC) is a group of gram-negative bacteria composed of at least 20 different species that cause diseases in plants,...
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RNA Transcription
The process of producing proteins from nucleotides is termed as gene expression. Genetic information present in the DNA, is first rewritten,...
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Co-option of the same ancestral gene family gave rise to mammalian and reptilian toxins
BackgroundEvolution can occur with surprising predictability when organisms face similar ecological challenges. For most traits, it is difficult to...
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A Structural Perspective on Gene Repression by Polycomb Repressive Complex 2
Polycomb Repressive Complex 2 (PRC2) is a major repressive chromatin complex formed by the Polycomb Group (PcG) proteins. PRC2 mediates...
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De novo identification of CD4+ T cell epitopes
CD4 + T cells recognize peptide antigens presented on class II major histocompatibility complex (MHC-II) molecules to carry out their function. The...
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Tight genetic linkage of genes causing hybrid necrosis and pollinator isolation between young species
The mechanisms of reproductive isolation that cause phenotypic diversification and eventually speciation are a major topic of evolutionary research....
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Inoculation of wheat with Bacillus sp. wp-6 altered amino acid and flavonoid metabolism and promoted plant growth
Key messageInoculation of wheat seedling with Bacillus sp. wp-6 changed amino acid metabolism and flavonoid synthesis and promoted plant growth.
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Detection of the PRAME Protein on the Surface of Melanoma Cells Using a Fluorescently Labeled Monoclonal Antibody
AbstractDetermination of the expression level of tumor marker PRAME protein is important both for predicting the course of the disease and for...
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Multi-omics data integration reveals link between epigenetic modifications and gene expression in sugar beet (Beta vulgaris subsp. vulgaris) in response to cold
BackgroundDNA methylation is thought to influence the expression of genes, especially in response to changing environmental conditions and...
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Alternative dimethylsulfoniopropionate biosynthesis enzymes in diverse and abundant microorganisms
Dimethylsulfoniopropionate (DMSP) is an abundant marine organosulfur compound with roles in stress protection, chemotaxis, nutrient and sulfur...
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QTL map** and candidate gene mining of flag leaf size traits in Japonica rice based on linkage map** and genome-wide association study
BackgroundAs one of the most important factors of the japonica rice plant, leaf shape affects the photosynthesis and carbohydrate accumulation...
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Potato Genome Editing: Recent Challenges and a Practical Procedure
Potato (Solanum tuberosum L.) is one of the most important staple crops, accounting for the fourth highest production in the world. To date, many...
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Contribution of horizontal gene transfer to the functionality of microbial biofilm on a macroalgae
Horizontal gene transfer (HGT) is thought to be an important driving force for microbial evolution and niche adaptation and has been show in vitro to...
