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Role of NLRP3 inflammasome in central nervous system diseases
The central nervous system (CNS) is the most delicate system in human body, with the most complex structure and function. It is vulnerable to trauma,...
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The role of T-LAK cell-originated protein kinase in targeted cancer therapy
Targeted therapy has gradually become the first-line clinical tumor therapy due to its high specificity and low rate of side effects. TOPK (T-LAK...
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Emerging Anticancer Metabolite, Carvacrol, and its Action Mechanism
Across the world, cancer is a major health problem in the population, causing ten million deaths a year in most countries. Studies on a promising...
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Flavonoid delivery by solid dispersion: a systematic review
The poor water solubility of flavonoids represents the greatest challenge to increasing the oral bioavailability of these compounds. Nevertheless,...
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Unraveling the role of autophagy regulation in Crohn's disease: from genetic mechanisms to potential therapeutics
Autophagy serves as the primary intracellular degradation mechanism in which damaged organelles and self-cytoplasmic proteins are transported to the...
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Bergenin ameliorates the progression of atherosclerosis by inhibiting oxidative stress, inflammation, and monocytes adhesion in human umbilical vein endothelial cells
BackgroundBergenin is a type of polyphenol derived from various medicinal plants and has multiple biological functions, including antioxidant,...
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7-Ethoxycoumarin rescued Caenorhabditis elegans from infection of COPD derived clinical isolate Pseudomonas aeruginosa through virulence and biofilm inhibition via targeting Rhl and Pqs quorum sensing systems
Pseudomonas aeruginosa is an ambidextrous Gram-negative contagium with density convoluted network defined quorum sensing, which enables the...
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Herbal-based therapeutics for diabetic patients with SARS-Cov-2 infection
Human SARS Coronavirus-2 (SARS-CoV-2) has infected more than 170 million people worldwide, being responsible for about 3.5 million deaths so far....
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In Silico Exploration of Therapeutics in Haematococcus pluvialis
Haematococcus, a freshwater chlorophyta belongs to the family of Haematococcaceae and well known for its ability to synthesize large amounts of...
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Targeting tumor-associated macrophages in hepatocellular carcinoma: biology, strategy, and immunotherapy
Hepatocellular carcinoma (HCC), one of the most malignant tumors, is characterized by its stubborn immunosuppressive microenvironment. As one of the...
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Eco-Metabolomic Studies of Medicinal Plants and Herbal Medicine
Ecometabolomics is becoming recognized as a valuable approach in ecological research, owing to recent advancements in technology, such as HNMR...
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Eco-metabolomic Studies of Medicinal Plants and Herbal Medicine
Ecometabolomics is becoming recognized as a valuable approach in ecological research, owing to recent advancements in technology, such as HNMR...
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Favorable Impacts of Drought Stress on the Quality of Medicinal Plants: Improvement of Composition and Content of Their Natural Products
This review deals with the well-known phenomenon that spice and medicinal plants grown under semi-arid conditions generally reveal significantly...
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A traditional medicine, respiratory detox shot (RDS), inhibits the infection of SARS-CoV, SARS-CoV-2, and the influenza A virus in vitro
BackgroundThe ongoing global pandemic of coronavirus disease 2019 (COVID-19) has resulted in the infection of over 128 million people and has caused...
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Hepatoprotective effects of baicalein against liver ischemia-reperfusion injury and partial hepatectomy in a rat model
BackgroundBaicalein is the main active flavonoid in Scutellariae Radix and is included in shosaikoto, a Kampo formula used for treating hepatitis and...
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Production of bilirubin via whole-cell transformation utilizing recombinant Corynebacterium glutamicum expressing a β-glucuronidase from Staphylococcus sp. RLH1
Bilirubin, a key active ingredient of bezoars with extensive clinical applications in China, is produced through a chemical process. However, this...
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Characterization and Cytotoxicity Assessment of Synthesized Palladium (II) Complex-Encapsulated Zinc Oxide Nanoparticles for Cancer Treatment
The treatment of cancer often leads to a range of adverse effects. Encapsulating drugs can mitigate these effects and enhance drug efficacy by...
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Stressed Plants: An Improved Source for Bioactive Phenolics
The generation of environmental changes, as well as the implementation of agricultural and cultural practices, induces a large number of problems...
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Mechanism of Melatonin Promotion of Flavonoid Biosynthesis in Ginkgo biloba
AbstractGinkgo biloba leaves are rich in flavonoids and have significant medicinal value. Exogenous hormones can affect flavonoids biosynthesis, but...
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Altitudinal variation of dragon fruit metabolite profiles as revealed by UPLC-MS/MS-based widely targeted metabolomics analysis
BackgroundGeographical factors affect the nutritional, therapeutic and commercial values of fruits. Dragon fruit ( Hylocereus spp ) is a popular fruit...
