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A large-scale RNAi screen reveals that mitochondrial function is important for meiotic chromosome organization in oocytes
In prophase of the first meiotic division, chromatin forms a compact spherical cluster called the karyosome within the enlarged oocyte nucleus in Droso...
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Impact of superovulation and in vitro fertilization on LINE-1 copy number and telomere length in C57BL/6 J mice blastocysts
ObjectiveMillions of babies have been conceived by IVF, yet debate about its safety to offspring continues. We hypothesized that superovulation and...
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Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease
SVA (SINE (short interspersed nuclear element)–VNTR (variable number of tandem repeats)– Alu ) retrotransposons remain active in humans and contribute...
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New insights into the functional role of retrotransposon dynamics in mammalian somatic cells
Retrotransposons are genetic elements present across all eukaryotic genomes. While their role in evolution is considered as a potentially beneficial...
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Four classic “de novo” genes all have plausible homologs and likely evolved from retro-duplicated or pseudogenic sequences
Despite being previously regarded as extremely unlikely, the idea that entirely novel protein-coding genes can emerge from non-coding sequences has...
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TEMM: A Curated Data Resource for Transposon Element-Based Molecular Markers in Plants
Transposon elements (TEs) are mobile genetic elements that can insert themselves into new locations and modify the plant genome. In recent years,...
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Das genetische Material
Genetik als Wissenschaft von der Vererbung untersucht den Aufbau des genetischen Materials, seine Eigenschaften, Funktionen und die Prozesse der...
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Differential transcriptional activation of copia family of different plant retrotransposons
Plant genomes contain a sizeable fraction, ranging from 14 to 75% of retrotransposons (class I elements), predominantly comprising LTR (Long Terminal...
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A comprehensive analysis of gorilla-specific LINE-1 retrotransposons
BackgroundLong interspersed element-1 (LINE-1 or L1) is the most abundant retrotransposons in the primate genome. They have approximately 520,000...
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Rethinking Genetics
Several developments and findings in the life sciences demand that we think about genetics in a completely new, or at least different, way. We know...
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Genomic Imprinting: A Paradigm for Epigenetics of Human Diseases
Genomic imprinting is a remarkable phenomenon through which certain genes show monoallelic expression depending on their parent of origin. While...
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Developmental dynamics of the single nucleus regulatory landscape of pig hippocampus
The hippocampus is a brain region associated with memory, learning and spatial navigation, its aging-related dysfunction is a common sign of...
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Post-transcriptional regulation in spermatogenesis: all RNA pathways lead to healthy sperm
Multiple RNA pathways are required to produce functional sperm. Here, we review RNA post-transcriptional regulation during spermatogenesis with...
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Endogenous retroviruses in the origins and treatment of cancer
Endogenous retroviruses (ERVs) are emerging as promising therapeutic targets in cancer. As remnants of ancient retroviral infections, ERV-derived...
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A Method for Detection of Somatic LINE-1 Insertions at the Single-Cell Level from Postmortem Human Brain
Long Interspersed Element-1 (LINE-1, L1) is a retrotransposon that has the ability to amplify its copy in the genome autonomously. L1Hs is a...
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Qualitative and Quantitative Analysis of DNA Cytidine Deaminase Activity
The human genome encodes eleven DNA cytidine deaminases in the AID/APOBEC family, which encompass endogenous roles ranging from genetic...
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Potential Geroprotectors – From Bench to Clinic
AbstractGeroprotectors are substances that slow down aging process and can be used for prevention of age-related diseases. Geroprotectors can improve...
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A haplotype-resolved genome assembly of the Nile rat facilitates exploration of the genetic basis of diabetes
BackgroundThe Nile rat ( Avicanthis niloticus ) is an important animal model because of its robust diurnal rhythm, a cone-rich retina, and a...
