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mTOR is involved in LRP5-induced osteogenic differentiation of normal and aged periodontal ligament stem cells in vitro
Periodontal ligament stem cells (PDLSCs) plays an important role in tissue engineering. As the age increased, the cell viability and osteogenic...
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Multiple Non-Canonical Base-Stacking Interactions as One of the Major Determinants of RNA Tertiary Structure Organization
AbstractStacking interactions of heterocyclic bases of ribonucleotides are one of the most important factors in the organization of RNA secondary and...
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Screening of Protein–Protein Interaction Modulators Using BRET-Based Technology
Protein–protein interactions (PPIs) play central roles in most molecular mechanisms underlying cellular and biological processes. Within the methods...
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Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation
Alternative splicing (AS) is tightly regulated during cell differentiation and development. AS events are prevalent in the testis, but the splicing...
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Cytochrome P450 for environmental remediation: catalytic mechanism, engineering strategies and future prospects
Environmental pollution is a global concern. Various organic compounds are released into the environment through wastewater, waste gas, and waste...
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Survey on large language model annotation of cellular senescence from figures in review articles
This study evaluated large language models (LLMs), particularly the GPT-4 with vision (GPT-4 V) and GPT-4 Turbo, for annotating biomedical figures,...
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Which contributes more to the relict flora distribution pattern in East Asia, geographical processes or climate change? New evidence from the phylogeography of Rehderodendron kwangtungense
BackgroundRelict species are important for enhancing the understanding of modern biogeographic distribution patterns. Although both geological and...
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Brain-specific Pd1 deficiency leads to cortical neurogenesis defects and depressive-like behaviors in mice
Embryonic neurogenesis is tightly regulated by multiple factors to ensure the precise development of the cortex. Deficiency in neurogenesis may...
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Role of ferroptosis on tumor progression and immunotherapy
Ferroptosis is triggered by intracellular iron leading to accumulation of lipid peroxidation consequent promotion of cell death. Cancer cell exhibits...
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Activity-dependent regulation of the BAX/BCL-2 pathway protects cortical neurons from apoptotic death during early development
During early brain development, homeostatic removal of cortical neurons is crucial and requires multiple control mechanisms. We investigated in the...
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Three-dimensional microCT imaging of mouse heart development from early post-implantation to late fetal stages
Comprehensive detailed characterization of new mouse models can be challenging due to the individual focus involved in develo** these models. Often...
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UHRF1 establishes crosstalk between somatic and germ cells in male reproduction
Sertoli cells (SCs) support and nourish germ cells (GCs) through their crosstalk during spermatogenesis. However, the underlying epigenetic mechanism...
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Development of the hyolaryngeal architecture in horseshoe bats: insights into the evolution of the pulse generation for laryngeal echolocation
BackgroundThe hyolaryngeal apparatus generates biosonar pulses in the laryngeally echolocating bats. The cartilage and muscles comprising the...
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Retinoschisin and novel Na/K-ATPase interaction partners Kv2.1 and Kv8.2 define a growing protein complex at the inner segments of mammalian photoreceptors
The RS1 gene on Xp 22.13 encodes retinoschisin which is known to directly interact with the retinal Na/K-ATPase at the photoreceptor inner segments....
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Age-related transcriptome changes in Sox2+ supporting cells in the mouse cochlea
BackgroundInner ear supporting cells (SCs) in the neonatal mouse cochlea are a potential source for hair cell (HC) regeneration, but several studies...
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Single-cell multiomic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed multiple myeloma
Markers that predict response and resistance to chimeric antigen receptor (CAR) T cells in relapsed/refractory multiple myeloma are currently...
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Structural Variations and Rearrangements in Bacterial Type II Toxin-Antitoxin Systems
Bacteria encode a wide range of survival and immunity systems, including CRISPR-Cas, restriction-modification systems, and toxin-antitoxin systems...
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Postnatal state transition of cardiomyocyte as a primary step in heart maturation
Postnatal heart maturation is the basis of normal cardiac function and provides critical insights into heart repair and regenerative medicine. While...
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Motoneurons innervation determines the distinct gene expressions in multinucleated myofibers
BackgroundNeuromuscular junctions (NMJs) are peripheral synapses connecting motoneurons and skeletal myofibers. At the postsynaptic side in...
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Investigation of SNP markers for the melatonin production trait in the Hu sheep with bulked segregant analysis
BackgroundAs an important reproductive hormone, melatonin plays an important role in regulating the reproductive activities of sheep and other...
