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Reproducibility of non-fasting plasma metabolomics measurements across processing delays
IntroductionProcessing delays after blood collection is a common pre-analytical condition in large epidemiologic studies. It is critical to evaluate...
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Phospholipase Superfamily: Structure, Functions, and Biotechnological Applications
Enzymes of the phospholipase superfamily are involved in lipid metabolism, as well as regulation of membrane composition, cell signaling, and...
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Genome-wide transcriptome profiling provides insights into the responses of maize (Zea mays L.) to diazotrophic bacteria
AimsWe applied for the first time a high-throughput transcriptome approach to elucidate biochemical and physiological mechanisms controlling early...
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Granulocyte colony-stimulating factor alters the systemic metabolomic profile in healthy donors
IntroductionPeripheral blood stem cells mobilized by granulocyte colony-stimulating factor (G-CSF) from healthy donors are commonly used for...
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Role of Lipid Composition, Physicochemical Interactions, and Membrane Mechanics in the Molecular Actions of Microbial Cyclic Lipopeptides
Several experimental and theoretical studies have extensively investigated the effects of a large diversity of antimicrobial peptides (AMPs) on model...
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The Deanna protocol supplement complex supports mitochondrial energy metabolism and prolongs lifespan in preclinical models of amyotrophic lateral sclerosis (ALS)
IntroductionAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of motor neurons causing progressive muscle weakness, paralysis, and...
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Maize multi-omics reveal roles for autophagic recycling in proteome remodelling and lipid turnover
The turnover of cytoplasmic material by autophagic encapsulation and delivery to vacuoles is essential for recycling cellular constituents,...
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Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies
BackgroundUntargeted mass spectrometry (MS)-based metabolomics data often contain missing values that reduce statistical power and can introduce bias...
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FTIR Analysis of Proteins and Protein–Membrane Interactions
Fourier transform infrared (FTIR) spectroscopy has become one of the major techniques of structural characterization of proteins, peptides, and...
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Nannochloropsis sp. ethanol extract prevents macrophage and LDL oxidation and enhances PON1 activity through the principal active compound lyso-diacylglyceryltrimethylhomoserine (lyso-DGTS)
Oxidation of macrophages and low-density lipoprotein (LDL) plays a role in atherogenesis, whereas high-density lipoprotein (HDL) and its associated...
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Are we close to defining a metabolomic signature of human obesity? A systematic review of metabolomics studies
IntroductionObesity is a disorder characterized by a disproportionate increase in body weight in relation to height, mainly due to the accumulation...
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Molecular recognition of microbial lipid-based antigens by T cells
The immune system has evolved to protect hosts from pathogens. T cells represent a critical component of the immune system by their engagement in...
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The role of lipids in mechanosensation
The ability of proteins to sense membrane tension is pervasive in biology. A higher-resolution structure of the Escherichia coli small-conductance...
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Spontaneous and Intrinsic Curvature of Lipid Membranes: Back to the Origins
We review the background behind the notions of spontaneous and intrinsic curvatures of lipid membranes with a goal to make clear a fundamental...
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Leaf lipidome and transcriptome profiling of Portulaca oleracea: characterization of lysophosphatidylcholine acyltransferase
Main conclusionPortulaca leaves serve as an alternative bioresource for edible PUFAs. Transcriptome data provide information to explore Portulaca as...
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EPR Studies on the Properties of Model Photoreceptor Membranes Made of Natural and Synthetic Lipids
The membranes of retina photoreceptors have unique lipid composition. They contain a high concentration of polyunsaturated docosahexaenoic acid, with...
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A novel lipid transfer protein from the pea Pisum sativum: isolation, recombinant expression, solution structure, antifungal activity, lipid binding, and allergenic properties
BackgroundPlant lipid transfer proteins (LTPs) assemble a family of small (7–9 kDa) ubiquitous cationic proteins with an ability to bind and...
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Seaweed Lipidomics in the Era of ‘Omics’ Biology: A Contemporary Perspective
Lipidomics, a branch of “omic” sciences, refers to the analysis of lipids on the systems level together with their interacting factors including...
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Sporobolus stapfianus: Insights into desiccation tolerance in the resurrection grasses from linking transcriptomics to metabolomics
BackgroundUnderstanding the response of resurrection angiosperms to dehydration and rehydration is critical for deciphering the mechanisms of how...
