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Organization of Ca2+ Signaling Microdomains in Cardiac Myocytes
Calcium signaling in cardiomyocytes regulates muscle contractile function and electrical signal propagation in the heart. While calcium influx in...
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Live-cell photoactivated localization microscopy correlates nanoscale ryanodine receptor configuration to calcium sparks in cardiomyocytes
Ca 2+ sparks constitute the fundamental units of Ca 2+ release in cardiomyocytes. Here we investigate how ryanodine receptors (RyRs) collectively...
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Changes in Activity of the Plasma Membrane H+-ATPase as a Link Between Formation of Electrical Signals and Induction of Photosynthetic Responses in Higher Plants
AbstractAction of numerous adverse environmental factors on higher plants is spatially-heterogenous; it means that induction of a systemic adaptive...
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Calcium Channels and Selective Neuronal Vulnerability in Parkinson’s Disease
Ca2+ entry through voltage-dependent ion channels (Cav) in the plasma membrane provides a signal coupling neuronal activity to a wide array of...
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Voltage-Dependent Calcium Channels (CaVs) and CatSper in Spermatogenic and Sperm Cells
As in most cell types, intracellular Ca2+ regulates many fundamental physiological functions in sperm and its progenitors. Ca2+ permeable and...
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Bortezomib-induced neuropathy is in part mediated by the sensitization of TRPV1 channels
TRPV1 is an ion channel that transduces noxious heat and chemical stimuli and is expressed in small fiber primary sensory neurons that represent...
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Ttm50 facilitates calpain activation by anchoring it to calcium stores and increasing its sensitivity to calcium
Calcium-dependent proteolytic calpains are implicated in a variety of physiological processes, as well as pathologies associated with calcium...
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Calcium signaling: breast cancer’s approach to manipulation of cellular circuitry
Calcium is a versatile element that participates in cell signaling for a wide range of cell processes such as death, cell cycle, division, migration,...
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Effect of three water-regimes on morpho-physiological, biochemical and yield responses of local and foreign olive cultivars under field conditions
BackgroundDrought stress is among the most serious threats jeopardizing the economic yield of crop plants in Iran. In particular, in response to...
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PINK1 contained in huMSC-derived exosomes prevents cardiomyocyte mitochondrial calcium overload in sepsis via recovery of mitochondrial Ca2+ efflux
BackgroundSepsis is a systemic inflammatory response to a local severe infection that may lead to multiple organ failure and death. Previous studies...
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Ca2+/calmodulin-mediated desensitization of glutamate receptors shapes plant systemic wound signalling and anti-herbivore defence
Plants rely on systemic signalling mechanisms to establish whole-body defence in response to insect and nematode attacks. GLUTAMATE RECEPTOR-LIKE ( GLR ...
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Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation
Calcium dynamics control synaptic transmission. Calcium triggers synaptic vesicle fusion, determines release probability, modulates vesicle...
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Ions and Pollen Tube Growth
Ions play a crucial role in the control of pollen tube growth. In this review we focus on four that seem especially important: calcium (Ca...
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Hypothermal effects on expression of regucalcin, a calcium-binding protein, in the livers of seawater- and fresh water–acclimated milkfish, Chanos chanos
Regucalcin (RGN) is a calcium-binding protein mainly expressed in the liver. It functions in regulating activities of several calcium-dependent...
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The Janus-faced role of TRPM2-S in retroperitoneal liposarcoma via increasing ROS levels
BackgroundRetroperitoneal liposarcoma (RPLS) is a specific soft tissue sarcoma with a high recurrence rate. The short isoform of transient receptor...
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Astrocytic NMDA Receptors
AbstractAstrocytic NMDA receptors (NMDARs) are heterotetramers, whose expression and properties are largely determined by their subunit composition....
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Mitochondria determine the sequential propagation of the calcium macrodomains revealed by the super-resolution calcium lantern imaging
Despite the wide application of super-resolution (SR) microscopy in biological studies of cells, the technology is rarely used to monitor functional...
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Role of Calcium Signalling During Plant–Herbivore Interaction
Plants and herbivores have co-evolved since long and plants have established sophisticated defence mechanisms for their protection. Plant defence...
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STIM2 regulates NMDA receptor endocytosis that is induced by short-term NMDA receptor overactivation in cortical neurons
Recent findings suggest an important role for the dysregulation of stromal interaction molecule (STIM) proteins, activators of store-operated Ca 2+ ...
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Calcium spikes, waves and oscillations in plant development and biotic interactions
The calcium ion (Ca 2+ ) is a universal signal in all eukaryotic cells. A fundamental question is how Ca 2+ , a simple cation, encodes complex...
