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Obesity impairs cardiolipin-dependent mitophagy and therapeutic intercellular mitochondrial transfer ability of mesenchymal stem cells
Mesenchymal stem cell (MSC) transplantation alleviates metabolic defects in diseased recipient cells by intercellular mitochondrial transport (IMT)....
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Proteomic Analysis of Serum Differentially Expressed Proteins Between Allergic Bronchopulmonary Aspergillosis and Asthma
BackgroundAllergic bronchopulmonary aspergillosis (ABPA) constantly develops in asthmatics, which has not been fully investigated.
Objectives ...
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Risk of exposure of a selected rural population in South Poland to allergenic mites. Part I: indoor acarofauna of one-family houses
The aim of this study was to investigate the occurrence of mites in dust samples from houses in agricultural areas of South Poland, with particular...
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Production of Pharmaceutical Proteins in Genetically Modified Seeds
In the last few decades, with the progress of plant genetic engineering, the use of plants as bioreactors has emerged as a promising alternative in...
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Allergic fungal airways disease (AFAD): an under-recognised asthma endotype
The term allergic fungal airways disease has a liberal definition based on IgE sensitisation to thermotolerant fungi and evidence of fungal-related...
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MicroRNA-629-3p Promotes Interleukin-13-Induced Bronchial Epithelial Cell Injury and Inflammation by Targeting FOXA2
ObjectiveAsthma is a chronic pulmonary inflammatory disease. MicroRNA (miR)-629-3p expression is reported to be up-regulated in the sputum of asthma...
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Zafirlukast promotes mitochondrial respiration by stimulating mitochondrial biogenesis in human bronchial epithelial cells
Lung diseases, including asthma, pose a serious global health issue. Loss of mitochondrial function and decreased mitochondrial biogenesis play...
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Lipid-Derived Mediators are Pivotal to Leukocyte and Lung Cell Responses in Sepsis and ARDS
Acute inflammation in the lung is essential for host defense against pathogens and other injuries but chronic or excessive inflammation can...
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Treatment of allergic eosinophilic asthma through engineered IL-5-anchored chimeric antigen receptor T cells
Severe eosinophilic asthma (SEA) is a therapy-resistant respiratory condition with poor clinical control. Treatment efficacy and patient compliance...
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The gut epithelium from feeding to fasting in the predatory soil mite Pergamasus longicornis (Mesostigmata: Parasitidae): one tissue, two roles
A review of acarine gut physiology based on published narratives dispersed over the historical international literature is given. Then, in an...
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Respiratory Mycoses in COPD and Bronchiectasis
Chronic obstructive pulmonary disease (COPD) and bronchiectasis represent chronic airway diseases associated with significant morbidity and...
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Drp1: Focus on Diseases Triggered by the Mitochondrial Pathway
Drp1 (Dynamin-Related Protein 1) is a cytoplasmic GTPase protein encoded by the DNM1L gene that influences mitochondrial dynamics by mediating...
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Effects of Heat Shock Protein 70 kDa in Allergic Airway Inflammation
Introduction Local elevation of extracellular heat shock protein 70 kDa (HSP70) concentration is an attribute of the acute phase of inflammation of...
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Oxidative Stress-Induced Mitochondrial Dysfunction and Asthma
Asthma is a well-recognized global concern with ever-increasing prevalence and economic burden worldwide. Genetic susceptibility and exposure to...
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Unraveling the therapeutic effects of mesenchymal stem cells in asthma
Asthma is a chronic inflammatory disease associated with airway hyper-responsiveness, chronic inflammatory response, and excessive structural...
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Potential Allergenic Risks of Entomophagy
Edible insects are a novel food source in the West, prompting the need for an assessment of their food security risks. One of the major concerns...
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The role of Staphylococcus aureus enterotoxin B in chronic rhinosinusitis with nasal polyposis
CRS with nasal polyps (CRSwNP) is a multifactorial disease, and various etiological factors like bacterial superantigens are known to develop this...
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P2Y14 Receptor as a Target for Neutrophilia Attenuation in Severe COVID-19 Cases: From Hematopoietic Stem Cell Recruitment and Chemotaxis to Thrombo‐inflammation
The global SARS-CoV-2 pandemic starting in 2019 has already reached more than 2.3 million deaths. Despite the scientific community’s efforts to...
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A specific combined long-chain polyunsaturated fatty acid supplementation reverses fatty acid profile alterations in a mouse model of chronic asthma
BackgroundThe immune-modulating potential of long-chain polyunsaturated fatty acids (LCPUFAs) based on their conversion into lipid mediators in...
