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Anti-aging and Rejuvenation Based on Stem Cell Therapy
Stem cells are present in the tissues and organs. These cells remain in a quiescent and undifferentiated state until it is physiologically necessary...
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Preserving root stem cell functionality under low oxygen stress: the role of nitric oxide and phytoglobins
Main conclusionThe preservation of quiescent center stem cell integrity in hypoxic roots by phytoglobins is exercised through their ability to...
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Cell Cycle-Related Clinical Applications
The cell cycle is a highly regulated and orchestrated mechanism of life that ensures successive division of a cell and precise replication of...
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Tissue mosaicism following stem cell aging: blood as an exemplar
Loss of stem cell regenerative potential underlies aging of all tissues. Somatic mosaicism, the emergence of cellular patchworks within tissues,...
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Cell Cycle Progression and Synchronization: An Overview
The cell cycle is the series of events that take place in a cell that drives it to divide and produce two new daughter cells. Through more than...
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Cell cycle regulators and bone: development and regeneration
Cell cycle regulators act as inhibitors or activators to prevent cancerogenesis. It has also been established that they can play an active role in...
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Emerging cell cycle related non-coding RNA biomarkers from saliva and blood for oral squamous cell carcinoma
The unnotified or undifferentiable early stages of oral squamous cell carcinoma (OSCC) progression are the prime reasons for late-stage detection and...
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Visualization of RNA Transcripts in Muscle Stem Cells Using Single-Molecule Fluorescence In Situ Hybridization
Uncovering the transcriptomic signatures of quiescent muscle stem cells elicits the regulatory networks on stem cell quiescence. However, the spatial...
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Decoding Human Hematopoietic Stem Cell Self-Renewal
Purpose of ReviewHematopoietic stem cells (HSCs) maintain blood and immune cell homeostasis by balancing quiescence, self-renewal, and...
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Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation
Loss of pancreatic β cells is the hallmark of type 1 diabetes, for which provision of insulin is the standard of care. While regenerative and stem...
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Understanding Hematopoietic Stem Cell Dynamics—Insights from Mathematical Modelling
Purpose of reviewHematopoietic stem cells (HSCs) drive blood-cell production (hematopoiesis). Out-competition of HSCs by malignant cells occurs in...
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Live-Cell Labeling and Artificial Intelligence Approaches for High-Resolution XYZT Imaging of Cytoskeletal Dynamics During Collective Cell Migration
Collective cell migration is crucial for a variety of pathophysiological processes including embryonic development, wound healing, carcinoma...
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The versatile roles of testrapanins in cancer from intracellular signaling to cell–cell communication: cell membrane proteins without ligands
The tetraspanins (TSPANs) are a family of four-transmembrane proteins with 33 members in mammals. They are variably expressed on the cell surface,...
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High Throughput Screening of Mitochondrial Bioenergetics in Myoblasts and Differentiated Myotubes
Skeletal muscles contain stem cells called satellite cells, which are essential for muscle regeneration. The population of satellite cells declines...
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Dual impacts of mesenchymal stem cell-derived exosomes on cancer cells: unravelling complex interactions
Mesenchymal stem cells (MSCs) are multipotent, self-renewing stromal cells found in a variety of adult tissues. MSCs possess a remarkable ability to...
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Local and systemic mechanisms that control the hair follicle stem cell niche
Hair follicles are essential appendages of the mammalian skin, as hair performs vital functions of protection, thermoregulation and sensation. Hair...
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Single-cell transcriptome analyses reveal critical regulators of spermatogonial stem cell fate transitions
BackgroundSpermatogonial stem cells (SSCs) are the foundation cells for continual spermatogenesis and germline regeneration in mammals. SSC...
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Plant Cell Cycle: Molecular Events, Regulation by External Factors and Phytohormones
AbstractThis lecture presents classical information and new data on the molecular events of the “basic” (core) cell cycle (CC) of plants. The impact...
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Cell-cell contact-driven EphB1 cis- and trans- signalings regulate cancer stem cells enrichment after chemotherapy
Reactivation of chemotherapy-induced dormant cancer cells is the main cause of relapse and metastasis. The molecular mechanisms underlying remain to...
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Emerging roles of mitochondrial functions and epigenetic changes in the modulation of stem cell fate
Mitochondria serve as essential organelles that play a key role in regulating stem cell fate. Mitochondrial dysfunction and stem cell exhaustion are...
