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Prodigiosin: a fascinating and the most versatile bioactive pigment with diverse applications
Synthetic pigments pose toxicity and harmful impacts on humans and environment. In this context, the exploration of microbial sources for producing...
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Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus Clonostachys compactiuscula FKR-0021
Three new antimalarial compounds, clonocoprogens A, B, and C, were isolated from the static culture of an Okinawan fungus, Clonostachys compactiuscula ...
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Fungal phthalimidines-chemodiversity, bioactivity and biosynthesis of a unique class of natural products
A wide range of natural products important for the engineering and drug design of pharmaceuticals comprise largely of nitrogen-based heterocycles....
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Chemical profiling of Streptomyces sp. for detection of potential pharmaceutical molecules
Streptomyces sp. SL-4 which had been isolated and taxonomically characterized during our earlier studies showed promising antibacterial activities....
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Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors
Aminoacyl-tRNA synthetases (aaRSs) play a central role in the translation of genetic code, serving as attractive drug targets. Within this family,...
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Systematic review on the application of machine learning to quantitative structure–activity relationship modeling against Plasmodium falciparum
Malaria accounts for over two million deaths globally. To flatten this curve, there is a need to develop new and high potent drugs against Plasmodium...
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Artemisia annua L.: Traditional Uses, Phytochemistry, and Pharmacological Activities
Artemisia annua L. is an annual, herbaceous, aromatic medicinal plant belonging to the family Asteraceae. It is mentioned in traditional Chinese...
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Antifungal Activity of Mefloquine Against Candida albicans Growth and Virulence Factors: Insights Into Mode of Action
The antimalarial drug Mefloquine has demonstrated antifungal activity against growth and virulence factors of Candida albicans . The current study...
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Drug repositioning for anti-tuberculosis drugs: an in silico polypharmacology approach
AbstractDevelopment of potential antitubercular molecules is a challenging task due to the rapidly emerging drug-resistant strains of Mycobacterium...
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Key insights into secondary metabolites from various Chaetomium species
AbstractEndophytic fungi have proved to be a major source of secondary metabolites, wherein the genus Chaetomium has emerged as a source of...
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Comparative study on Antibacterial efficacy of a series of chromone sulfonamide derivatives against drug-resistant and MDR-isolates
Sulfonamide derivatives have numerous pharmaceutical applications having antiviral, antibacterial, antifungal, antimalarial, anticancer, and...
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A novel aromatic compound from the fungus Synnemellisia sp. FKR-0921
The filamentous fungus Synnemellisia sp. strain FKR-0921 was obtained from soil collected on Kume Island, Okinawa. The MeOH extract of FKR-0921...
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Cellular thermal shift assay for the identification of drug–target interactions in the Plasmodium falciparum proteome
Despite decades of research, little is known about the cellular targets and the mode of action of the vast majority of antimalarial drugs. We...
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Phytochemistry and Pharmacology of Genus Artocarpus: A Review on Current Status of Knowledge
AbstractArtocarpus (Moraceae) species have been widely studied for phytochemical components and pharmacological activity. This review aims to...
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Drug Resistance in Plasmodium sp. and Novel Antimalarial Natural Products-Emerging Trends
Malaria is one of the major infectious diseases which continues to be a serious threat in the develo** countries. The burden of malaria is getting...
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Synthetic, biological and optoelectronic properties of phenoxazine and its derivatives: a state of the art review
Phenoxazines have sparked a lot of interest owing to their numerous applications in material science, organic light-emitting diodes, photoredox...
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Unveiling the pharmaceutical and therapeutic potentials of Bambusa vulgaris essential oil
In the present study, we attempted to provide a comprehensive perspective towards the exploration of essential oil from Bambusa vulgaris plant as an...
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Modulation of the Host-Parasite Redox Metabolism to Potentiate Antimalarial Drug Efficiency
Artemisinin-based combination therapy (ACT) is nowadays the most effective treatment for P. falciparum malaria: artemisinin is the most active drug...
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Molecular iodine catalyzed C(sp2)–H sulfenylation of biologically active enaminone compounds under mechanochemical conditions and studies on their biocidal activity including molecular docking and DFT
Here we demonstrated a solvent free, mechanochemical I 2 catalyzed C(sp2)–H sulfenylation of enaminones under grinding condition. Only catalytic...
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Cyclical regression covariates remove the major confounding effect of cyclical developmental gene expression with strain-specific drug response in the malaria parasite Plasmodium falciparum
BackgroundThe cyclical nature of gene expression in the intraerythrocytic development cycle (IDC) of the malaria parasite, Plasmodium falciparum ,...
