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Astrocytes: new evidence, new models, new roles
Astrocytes have been in the limelight of active research for about 3 decades now. Over this period, ideas about their function and role in the...
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High activity and high functional connectivity are mutually exclusive in resting state zebrafish and human brains
BackgroundThe structural connectivity of neurons in the brain allows active neurons to impact the physiology of target neuron types with which they...
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Peripheral NOD-like receptor deficient inflammatory macrophages trigger neutrophil infiltration into the brain disrupting daytime locomotion
Inflammation is known to disrupt normal behavior, yet the underlying neuroimmune interactions remain elusive. Here, we investigated whether...
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Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication
Alcohol is among the most widely used psychoactive substances worldwide. Ethanol metabolites such as acetate, thought to be primarily the result of...
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Miniaturized head-mounted microscope for whole-cortex mesoscale imaging in freely behaving mice
The advent of genetically encoded calcium indicators, along with surgical preparations such as thinned skulls or refractive-index-matched skulls, has...
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Enhanced excitability but mature action potential waveforms at mossy fiber terminals of young, adult-born hippocampal neurons in mice
Adult-born granule neurons pass through immature critical periods where they display enhanced somatic excitability and afferent plasticity, which is...
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Spectrin-beta 2 facilitates the selective accumulation of GABAA receptors at somatodendritic synapses
Fast synaptic inhibition is dependent on targeting specific GABA A R subtypes to dendritic and axon initial segment (AIS) synapses. Synaptic GABA A Rs...
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High-Resolution Imaging of Mitochondria and Mitochondrial Nucleoids in Differentiated SH-SY5Y Cells
Mitochondria are highly dynamic organelles which form intricate networks with complex dynamics. Mitochondrial transport and distribution are...
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Optogenetic manipulation of cellular communication using engineered myosin motors
Cells achieve highly efficient and accurate communication through cellular projections such as neurites and filopodia, yet there is a lack of...
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Improved green and red GRAB sensors for monitoring spatiotemporal serotonin release in vivo
The serotonergic system plays important roles in both physiological and pathological processes, and is a therapeutic target for many psychiatric...
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Architecture of the subthalamic nucleus
The subthalamic nucleus (STN) is a major neuromodulation target for the alleviation of neurological and neuropsychiatric symptoms using deep brain...
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Characterization of Complexes and Supramolecular Structures by Electron Microscopy
Recent advancements in cryo-electron microscopy (cryo-TEM) have enabled the determination of structures of macromolecular complexes at near-atomic...
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Antigen retrieval and clearing for whole-organ immunofluorescence by FLASH
Advances in light-sheet and confocal microscopy now allow imaging of cleared large biological tissue samples and enable the 3D appreciation of cell...
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Three-dimensional nanoscopy of whole cells and tissues with in situ point spread function retrieval
Single-molecule localization microscopy is a powerful tool for visualizing subcellular structures, interactions and protein functions in biological...
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All-optical interrogation of neural circuits in behaving mice
Recent advances combining two-photon calcium imaging and two-photon optogenetics with computer-generated holography now allow us to read and write...
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Glial AP1 is activated with aging and accelerated by traumatic brain injury
The emergence of degenerative disease after traumatic brain injury (TBI) is often described as an acceleration of normal age-related processes....
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MiRNA-132/212 regulates tight junction stabilization in blood–brain barrier after stroke
MicroRNA-132/212 has been supposed as a critical gene related to the blood–brain barrier (BBB) protection after stroke, but its regulation pathway...
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Photoresponsive Hydrogels for Studying Mechanotransduction of Cells
Hydrogels are important platform materials for in vitro cellular studies. Mechanistic studies on durotaxis, the directional movement of a cell...
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Robust and adjustable dynamic scattering compensation for high-precision deep tissue optogenetics
The development of high-precision optogenetics in deep tissue is limited due to the strong optical scattering induced by biological tissue. Although...
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Automated neuron tracking inside moving and deforming C. elegans using deep learning and targeted augmentation
Reading out neuronal activity from three-dimensional (3D) functional imaging requires segmenting and tracking individual neurons. This is challenging...
