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Lymphoid tissue inducer cells in cancer: a potential therapeutic target
Tumor cells are dynamic in nature; these cells first acquire immune surveillance and then escape from the immune system. Hence, progressed cancer...
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Human umbilical cord mesenchymal stem cells ameliorate colon inflammation via modulation of gut microbiota-SCFAs-immune axis
BackgroundInflammatory bowel disease (IBD) is a global health problem in which gut microbiota dysbiosis plays a pivotal pathogenic role. Mesenchymal...
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RETRACTED ARTICLE: Overexpression of TGFβ1 in murine mesenchymal stem cells improves lung inflammation by impacting the Th17/Treg balance in LPS-induced ARDS mice
BackgroundT helper 17 cells (Th17)/regulatory T cells (Treg), as subtypes of CD4 + T cells, play an important role in the inflammatory response of...
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Role and Interrelationship Between Myeloid-Derived Suppressor Cells and CD4+ T Cells in Different Types of Infections: A Review
Myeloid-Derived Suppressor Cells (MDSCs), also known as ‘Natural Suppressor Cells (NSCs)’, ‘Immature Myeloid Cells, (IMCs), or ‘Myeloid Suppressor...
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VEGFR affects miR-3200-3p-mediated regulatory T cell senescence in tumour-derived exosomes in non-small cell lung cancer
Numerous studies have demonstrated that regulatory T (Treg) cells play an important role in the tumour microenvironment (TME). The aim of this study...
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Osteogenic differentiation of mesenchymal stem cells promotes c-Jun-dependent secretion of interleukin 8 and mediates the migration and differentiation of CD4+ T cells
BackgroundThe immune system and the skeletal system have complex interactions in the bone marrow and even in the joints, which has promoted the...
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Role of T cells in liver metastasis
The liver is a major metastatic site (organ) for gastrointestinal cancers (such as colorectal, gastric, and pancreatic cancers) as well as...
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Participation of Mesenchymal Stem Cells in the Tumor Process
Although most mesenchymal stem cell (MSCs) studies have focused on evaluating the safety and efficacy of their use as therapeutic agents in...
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Mesenchymal stem cells regulate the Th17/Treg cell balance partly through hepatocyte growth factor in vitro
IntroductionMesenchymal stem cells (MSCs) exert immunomodulatory functions by inducing the development and differentiation of naive T cells into T...
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Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates
Regulatory T cells (Tregs) play an important role in controlling inflammation and limiting autoimmunity, but their phenotypes at inflammatory sites...
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Reduced frequency of circulating regulatory T cells and their related immunosuppressive mediators in treated celiac patients
BackgroundRegulatory T cells (Tregs) have an important role in the control of the immune responses. This study aimed to compare the frequency of...
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BAP31 affects macrophage polarization through regulating helper T cells activation
Previously, we reported that B cell receptor associated protein 31 (BAP31) is a positive regulator on T-cells activation. Helper T cells [cluster of...
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Glutamine metabolism in Th17/Treg cell fate: applications in Th17 cell-associated diseases
Alteration in the Th17/Treg cell balance is implicated in various autoimmune diseases and these disease-associated pathologies. Increasing...
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Effect of small extracellular vesicles derived from IL-10-overexpressing mesenchymal stem cells on experimental autoimmune uveitis
BackgroundAutoimmune uveitis is a sight-threatening intraocular inflammation mainly caused by immune dysregulation. The development of safe and...
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CAR Cells beyond Classical CAR T Cells: Functional Properties and Prospects of Application
AbstractChimeric antigen receptors (CARs) are genetically engineered receptors that recognize antigens and activate signaling cascades in a cell....
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In Situ Characterization of Human Follicular Helper CD4 T Cells
The development of an effective humoral response to pathogens and immunogens is a multiphase biological process, which is mediated by the coordinated...
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Infusion of two-dose mesenchymal stem cells is more effective than a single dose in a dilated cardiomyopathy rat model by upregulating indoleamine 2,3-dioxygenase expression
Background and aimsThe therapeutic efficacy of single-dose mesenchymal stromal cell (MSC) therapy for heart failure (HF) remains inconsistent. This...
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Mesenchymal Stem Cells, Cancer Stem Cells (CSCs), and Circulating Tumor Cells (CTCs): Roles and Combinations in Tumor Growth and Dissemination
Mesenchymal stem cells are considered the key cells in tissue regeneration after damage. MSCs play a fundamental role in cancer since they can be...
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Transcriptional regulation of Treg homeostasis and functional specification
CD4 + Foxp3 + regulatory T (Treg) cells are key players in kee** excessive inflammation in check. Mounting evidence has shown that Treg cells exert...
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Loss of chromosome Y in regulatory T cells
BackgroundMosaic loss of chromosome Y (LOY) in leukocytes is the most prevalent somatic aneuploidy in aging humans. Men with LOY have increased risks...
