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Overexpressing plant ferredoxin-like protein enhances photosynthetic efficiency and carbohydrates accumulation in Phalaenopsis
Crassulacean acid metabolism (CAM) is one of three major models of carbon dioxide assimilation pathway with better water-use efficiency and slower...
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Diphtheria toxin, diphtheria-related fusion protein toxins, and the molecular mechanism of their action against eukaryotic cells
Diphtheria toxin remains one of the most successfully studied of the bacterial protein toxins. A detailed understanding of the structure function...
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Role of the human solute carrier family 14 member 1 gene in hypoxia-induced renal cell carcinoma occurrence and its enlightenment to cancer nursing
BackgroundHypoxia is considered a critical contributor to renal cell carcinoma progression, including invasion and metastasis. However, the potential...
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Alanine-specific appetite in slow growing chickens is associated with impaired glucose transport and TCA cycle
BackgroundThe rate of protein accretion and growth affect amino acid requirements in young animals. Differences in amino acid metabolism contribute...
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An updated review on oral protein-based antigen vaccines efficiency and delivery approaches: a special attention to infectious diseases
Various infectious agents affect human health via the oral entrance. The majority of pathogens lack approved vaccines. Oral vaccination is a...
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Oral Delivery of SARS-CoV-2 DNA Vaccines Using Attenuated Salmonella typhimurium as a Carrier in Rat
AbstractThe 2019 novel coronavirus disease (COVID-19) is the disease that has been identified as severe acute respiratory syndrome coronavirus 2...
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An integrated bioinformatic investigation of mitochondrial solute carrier family 25 (SLC25) in colon cancer followed by preliminary validation of member 5 (SLC25A5) in tumorigenesis
Solute carrier family 25 (SLC25) encodes transport proteins at the inner mitochondrial membrane and functions as carriers for metabolites. Although...
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Current non-invasive strategies for brain drug delivery: overcoming blood–brain barrier transport
BackgroundThe blood-brain barrier (BBB) is a complex and dynamic structure that serves as a gatekeeper, restricting the migrations of most compounds...
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Amino Acids Transport as an Index of Cancer Stem Cells Dysregulation
The appearance, proliferation, metastasis, and even resistance to chemotherapy depend on the molecular identity of the so-called Cancer Stem Cells...
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Plastoquinol Oxidation: Rate-Limiting Stage in the Electron Transport Chain of Chloroplasts
AbstractThis work is devoted to theoretical study of functioning of the cytochrome (Cyt) b 6 f complex (plastoquinol:plastocyanin oxidoreductase) of...
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Identification and characterization of endogenous biomarkers for hepatic vectorial transport (OATP1B3-P-gp) function using metabolomics with serum pharmacology
The organic anion-transporting polypeptide 1B3 and P-glycoprotein (P-gp) provide efficient directional transport (OATP1B3-P-gp) from the blood to the...
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Phosphate, calcium, and vitamin D signaling, transport, and metabolism in the endometria of cyclic ewes
BackgroundRecent evidence suggests important roles for progesterone (P4) and interferon tau in the regulation of calcium, phosphate, and vitamin D...
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Pathway engineering facilitates efficient protein expression in Pichia pastoris
AbstractPichia pastoris has been recognized as an important platform for the production of various heterologous proteins in recent years. The strong...
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Protein Design Strategies for the Structural–Functional Studies of G Protein-Coupled Receptors
AbstractG protein-coupled receptors (GPCRs) are an important family of membrane proteins responsible for many physiological functions in human body....
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Mesenchymal stem cell-derived extracellular vesicles: a regulator and carrier for targeting bone-related diseases
The escalating threat of bone-related diseases poses a significant challenge to human health. Mesenchymal stem cell (MSC)-derived extracellular...
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Identifying essential proteins from protein–protein interaction networks based on influence maximization
BackgroundEssential proteins are indispensable to the development and survival of cells. The identification of essential proteins not only is helpful...
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Advancement of Engineered Exosomes to Deliver Therapeutic Protein Cargos in Brain Disorders
The potential use of exosomes as biomarkers for central nervous system disorders is an intriguing idea because they can monitor disease development,...
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Mitochondrial carrier 1 (MTCH1) governs ferroptosis by triggering the FoxO1-GPX4 axis-mediated retrograde signaling in cervical cancer cells
Cervical cancer is one of the leading causes of cancer death in women. Mitochondrial-mediated ferroptosis (MMF) is a recently discovered form of...
