Search
Search Results
-
Structural basis of temperature sensation by the TRP channel TRPV3
We present structures of mouse TRPV3 in temperature-dependent open, closed and intermediate states that suggest two-step activation of TRPV3 by heat....
-
Congenital Conditions of Hypophosphatemia Expressed in Adults
The main congenital conditions of hypophosphatemia expressed in adulthood include several forms of hereditary hypophosphatemic rickets and a...
-
TRPV1 Ion Channel: Structural Features, Activity Modulators, and Therapeutic Potential
AbstractAlthough TRPV1 ion channel has been attracting researchers’ attention for many years, its functions in animal organisms, the principles of...
-
Organellar TRP channels
Mammalian transient receptor potential (TRP) channels mediate Ca 2+ flux and voltage changes across membranes in response to environmental and...
-
Transient Receptor Potential (TRP) Channels
Transient Receptor Potential (TRP) channels are evolutionarily conserved integral membrane proteins. The mammalian TRP superfamily of ion channels...
-
Structure and gating mechanism of the transient receptor potential channel TRPV3
Transient receptor potential vanilloid subfamily member 3 (TRPV3) channel plays a crucial role in skin physiology and pathophysiology. Mutations in...
-
TRPM8-androgen receptor association within lipid rafts promotes prostate cancer cell migration
In prostate carcinogenesis, androgens are known to control the expression of the transient receptor potential melastatin 8 (TRPM8) protein via...
-
-
Insights into phytase-containing transgenic Lemna minor (L.) as a novel feed additive
This study assessed the effect of supplementation of novel transgenic phytase on growth performance and bone mineralization in Korean native broiler...
-
Immune aspects of the bi-directional neuroimmune facilitator TRPV1
A rapidly growing area of interest in biomedical science involves the reciprocal crosstalk between the sensory nervous and immune systems. Both of...
-
αKlotho–FGF23 interactions and their role in kidney disease: a molecular insight
Following the serendipitous discovery of the ageing suppressor, αKlotho (αKl), several decades ago, a growing body of evidence has defined a pivotal...
-
Structures of TRPV2 in distinct conformations provide insight into role of the pore turret
Cation channels of the transient receptor potential (TRP) family serve important physiological roles by opening in response to diverse intra- and...
-
Klotho protein: Its role in aging and central nervous system pathology
This review is devoted to Klotho protein and recent evidences for its functions in the brain. Information on transcriptional regulation of the klotho ...
-
Methods for Evaluation of Vascular Endothelial Cell Function with Transient Receptor Potential (TRP) Channel Drugs
Vascular endothelial transient potential (TRP) channels, located mostly on the plasma membrane of cells, are critical in regulatory and...
-
Effect of Everolimus on Heterogenous Renal Cancer Cells Populations Including Renal Cancer Stem Cells
The aim of this study was to compare effect of everolimus on growth of different renal cell carcinoma (RCC) populations and develop experimental...
-
Prospects of Parathyroid Hormone in Therapeutic Intervention
Biologically active peptides and proteins have wide applications as therapeutic agents as well as diagnostics. Parathyroid hormone (PTH), a...
-
Constitutive calcium entry and cancer: updated views and insights
Tight control of basal cytosolic Ca 2+ concentration is essential for cell survival and to fine-tune Ca 2+ -dependent cell functions. A way to control...
-
Calcium Ion in Biological Systems
Calcium is a fundamental element in all biological system. It plays indispensable role in almost all biochemical signalling and physiological...
-
Calcium-binding protein S100A14 induces differentiation and suppresses metastasis in gastric cancer
S100A14 is a calcium-binding protein involved in cell proliferation and differentiation as well as the metastasis of human tumors. In this study, we...
