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Hypomagnesemia and Its Relationship with Oxidative Stress Markers in Women with Breast Cancer
Reduced serum magnesium concentrations in women with breast cancer compromises one of the antioxidant defense system involved in the carcinogenesis...
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Silver nanoparticles and silver ions cause inflammatory response through induction of cell necrosis and the release of mitochondria in vivo and in vitro
Owing to the excellent antibacterial and antiviral activity, silver nanoparticles have a widespread use in the food and pharmaceutical industries....
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Endocytosis and Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and is the most common cause of dementia. The pathogenesis of AD still remains...
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The role of Nod-like receptor protein 3 inflammasome activated by ion channels in multiple diseases
The inflammasome is a multimeric protein complex located in the cytoplasm that is activated by many factors and subsequently promotes the release of...
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CAF-derived midkine promotes EMT and cisplatin resistance by upregulating lncRNA ST7-AS1 in gastric cancer
This study aimed to investigate the role of cancer-associated fibroblast (CAF)-derived midkine (MK) in cisplatin (DDP) resistance. The primary...
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Sperm freezing damage: the role of regulated cell death
Substantial progress in research on sperm cryopreservation has occurred since the twentieth century, especially focusing on improving sperm freezing...
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Genome-wide association study of population-standardised cognitive performance phenotypes in a rural South African community
Cognitive function is an indicator for global physical and mental health, and cognitive impairment has been associated with poorer life outcomes and...
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NMDARs antagonist MK801 suppresses LPS-induced apoptosis and mitochondrial dysfunction by regulating subunits of NMDARs via the CaM/CaMKII/ERK pathway
Lipopolysaccharide (LPS) displays a robust immunostimulatory ability upon Toll-like receptor 4 (TLR4) recognition. N-methyl-D-aspartate receptors...
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Direct targeting of DOCK4 by miRNA-181d in oxygen-glucose deprivation/reoxygenation-mediated neuronal injury
The miRNA-181 (miR-181) family regulates neuronal persistence during cerebral ischemia/reperfusion injury (CI/RI). Since the effect of miR-181d on...
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A novel role for KIFC1-MYH9 interaction in triple-negative breast cancer aggressiveness and racial disparity
African American (AA) women are twice as likely to develop triple-negative breast cancer (TNBC) as women of European descent. Additionally, AA women...
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TRP channels associated with macrophages as targets for the treatment of obese asthma
Globally, obesity and asthma pose significant health challenges, with obesity being a key factor influencing asthma. Despite this, effective...
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Adipose stem cells-released extracellular vesicles as a next-generation cargo delivery vehicles: a survey of minimal information implementation, mass production and functional modification
ObjectivesTo investigate current situation of minimal information implementation highlighted by minimal information for studies of extracellular...
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Structure of human TRPM8 channel
TRPM8 is a non-selective cation channel permeable to both monovalent and divalent cations that is activated by multiple factors, such as temperature,...
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Internalization of apoptotic cells during efferocytosis requires Mertk-mediated calcium influx
Phagocytosis of apoptotic cells, called efferocytosis, requires calcium inside and outside of phagocytes. Due to its necessity, calcium flux is...
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Pore-forming proteins as drivers of membrane permeabilization in cell death pathways
Regulated cell death (RCD) relies on activation and recruitment of pore-forming proteins (PFPs) that function as executioners of specific cell death...
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Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis
BackgroundThe synthesis and secretion of renin in juxtaglomerular (JG) cells are closely regulated by the blood pressure. To date, however, the...
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Structure, regulation, and mechanisms of nonmuscle myosin-2
Members of the myosin superfamily of molecular motors are large mechanochemical ATPases that are implicated in an ever-expanding array of cellular...
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Application of Viruses for Gene Therapy and Vaccine Development
Although viruses have been demonstrated to cause a serious threat to our health, further confirmed by the current coronavirus virus pandemic,...
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Voltage-Gated Ca2+ Channels. Lessons from Knockout and Knock-in Mice
Functional diversification of voltage-gated Ca2+ channels is underlain by the existence of multiple α1-subunit-encoding genes. To define Ca2+ channel...
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Induction of Cell Death in Pancreatic Tumors by Zinc and Its Fluorescence Chelator TSQ
Pancreatic ductal adenocarcinoma is a devastating cancer and is the fourth-leading cause of cancer death in the USA. Zinc is abundant in the...
