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PDB2Vec: Using 3D Structural Information for Improved Protein Analysis
In recent years, machine learning methods have shown remarkable results in various protein analysis tasks, including protein classification, folding...
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Structural basis for the dynamic chaperoning of disordered clients by Hsp90
Molecular chaperone heat shock protein 90 (Hsp90) is a ubiquitous regulator that fine-tunes and remodels diverse client proteins, exerting profound...
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Network embedding framework for driver gene discovery by combining functional and structural information
Comprehensive analysis of multiple data sets can identify potential driver genes for various cancers. In recent years, driver gene discovery based on...
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Structural Analysis of Protein Complexes by Cryo-Electron Microscopy
Structural studies of bio-complexes using single particle cryo-Electron Microscopy (cryo-EMCryo- electron microscopy (cryo-EM)) is nowadays a...
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Explicit knowledge of task structure is a primary determinant of human model-based action
Explicit information obtained through instruction profoundly shapes human choice behaviour. However, this has been studied in computationally simple...
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The microcopepod family Oncaeidae: state of knowledge and perspectives
Since the discovery of the first oncaeid copepod described by Philippi in 1843 as Oncaea venusta , great progress has been achieved regarding the...
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Small RNA structural biochemistry in a post-sequencing era
High-throughput sequencing has had an enormous impact on small RNA research during the past decade. However, sequencing only offers a one-dimensional...
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Identifying environmental factors affecting the microbial community composition on outdoor structural timber
AbstractTimber wood is a building material with many positive properties. However, its susceptibility to microbial degradation is a major challenge...
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Protein remote homology detection and structural alignment using deep learning
Exploiting sequence–structure–function relationships in biotechnology requires improved methods for aligning proteins that have low sequence...
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Chronic Winds Reduce Tropical Forest Structural Complexity Regardless of Climate, Topography, or Forest Age
Tropical forests are the world’s most structurally complex ecosystems, providing key functions like biomass accumulation, which is linked to this...
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Structural and functional complexity of HSP90 in cellular homeostasis and disease
Heat shock protein 90 (HSP90) is a chaperone with vital roles in regulating proteostasis, long recognized for its function in protein folding and...
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GM1 structural requirements to mediate neuronal functions
Since the 1980s, it has been known that the administration of ganglioside GM1 to cultured cells induced or enhanced neuronal differentiation. GM1...
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Noisecut: a python package for noise-tolerant classification of binary data using prior knowledge integration and max-cut solutions
BackgroundClassification of binary data arises naturally in many clinical applications, such as patient risk stratification through ICD codes. One of...
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Graph regularized non-negative matrix factorization with prior knowledge consistency constraint for drug–target interactions prediction
BackgroundIdentifying drug–target interactions (DTIs) plays a key role in drug development. Traditional wet experiments to identify DTIs are...
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The expanding organelle lipidomes: current knowledge and challenges
Lipids in cell membranes and subcellular compartments play essential roles in numerous cellular processes, such as energy production, cell signaling...
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Advancing drug–target interaction prediction: a comprehensive graph-based approach integrating knowledge graph embedding and ProtBert pretraining
BackgroundThe pharmaceutical field faces a significant challenge in validating drug target interactions (DTIs) due to the time and cost involved,...
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Structural and Functional Dynamics of Bacterial World for Sustainability
Plants are associated with an abundance of diverse microbes. Plants have evolved with a multitude of microorganisms that profoundly benefit plant...
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Fast and accurate genome-wide predictions and structural modeling of protein–protein interactions using Galaxy
BackgroundProtein–protein interactions play a crucial role in almost all cellular processes. Identifying interacting proteins reveals insight into...
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Structural and functional implications of leucine-rich repeats in toll-like receptor1 subfamily
Leucine-rich repeats (LRRs) – the protein–protein and protein–ligand interaction motif of proteins participating in a plethora of functions in...
