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Pig and Mouse Models of Hyperlipidemia and Atherosclerosis
Atherosclerosis is a chronic inflammatory disorder that is the underlying cause of most cardiovascular disease. Resident cells of the artery wall and...
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Soil organic carbon storage in forest restoration models and environmental conditions
The scale of forest and landscape restoration is expected to increase during the UN Decade on Ecosystem Restoration and its contribution to the...
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Transmissibility and pathogenicity of SARS-CoV-2 variants in animal models
As of February 2022, SARS-CoV-2 is still one of the most serious public health threats due to its high mortality rate and rapid spread of novel...
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Innovative Design, Materials, and Construction Models for BioCities
Realising the transition to BioCities, which function as holistically integrated systems similar to natural ecosystems, will require not just the...
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Animal models of drug-induced pulmonary fibrosis: an overview of molecular mechanisms and characteristics
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by progressive loss of pulmonary function. Drug-induced...
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Three Dimensional Bioprinting for Hepatic Tissue Engineering: From In Vitro Models to Clinical Applications
Fabrication of functional organs is the holy grail of tissue engineering and the possibilities of repairing a partial or complete liver to treat...
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A multi-step modelling approach to evaluate the fuel consumption, emissions, and costs in forest operations
Assessing the financial, energy and emission levels associated with alternative harvesting prescriptions, techniques, and technologies is crucial to...
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J-SPACE: a Julia package for the simulation of spatial models of cancer evolution and of sequencing experiments
BackgroundThe combined effects of biological variability and measurement-related errors on cancer sequencing data remain largely unexplored. However,...
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Differential contribution for ERK1 and ERK2 kinases in BRAFV600E-triggered phenotypes in adult mouse models
The BRAF gene is mutated in a plethora of human cancers. The majority of such molecular lesions result in the expression of a constitutively active...
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Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins
Addressing the elusive specificity of cysteine cathepsins, which in contrast to caspases and trypsin-like proteases lack strict specificity...
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Atomistic ensemble of active SHP2 phosphatase
SHP2 phosphatase plays an important role in regulating several intracellular signaling pathways. Pathogenic mutations of SHP2 cause developmental...
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Syngeneic leukemia models using lentiviral transgenics
Animal models are necessary to study cancer and develop treatments. After decades of intensive research, effective treatments are available for only...
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Animal models for researching approaches to therapy of Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is a relatively widespread genetic disease which develops as a result of a mutation in the gene DMD encoding...
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Spatial variability of soil properties, nitrogen balance and nitrate leaching using digital methods on heterogeneous arable fields in southern Germany
In this study, the spatial variability of nitrogen (N) balances and potential nitrate leaching were determined in heterogeneous arable fields in...
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Lipid droplets and perilipins in canine osteosarcoma. Investigations on tumor tissue, 2D and 3D cell culture models
Lipid droplets were identified as important players in biological processes of various tumor types. With emphasis on lipid droplet-coating proteins...
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A genome on shaky ground: exploring the impact of mitochondrial DNA integrity on Parkinson’s disease by highlighting the use of cybrid models
Mitochondria play important roles in the regulation of key cellular processes, including energy metabolism, oxidative stress response, and signaling...
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Tradeoffs between resources and risks shape the responses of a large carnivore to human disturbance
Wide-ranging carnivores experience tradeoffs between dynamic resource availabilities and heterogeneous risks from humans, with consequences for their...
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The New Frontier of Three-Dimensional Culture Models to Scale-Up Cancer Research
In vitro cancer research models require the utmost accuracy and precision to effectively investigate physiological pathways and mechanisms, as well...
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Human iPSC-Derived Neural Models for Studying Alzheimer’s Disease: from Neural Stem Cells to Cerebral Organoids
During the past two decades, induced pluripotent stem cells (iPSCs) have been widely used to study mechanisms of human neural development, disease...
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Applications of 2D Cell Models
Outline The 2D vertex model was applied to elucidate the mechanism of wound healing of the epithelium through extension of surrounding epithelial...