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The cell surface is the place to be for brassinosteroid perception and responses
Adjusting the microenvironment around the cell surface is critical to responding to external cues or endogenous signals and to maintaining cell...
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Physiological significance of bistable circuit design in metabolic homeostasis: role of integrated insulin-glucagon signalling network
BackgroundInsulin and glucagon signalling pathways operate in a synchronised manner to regulate metabolic homeostasis in different physiological...
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Non-canonical non-genomic morphogen signaling in anucleate platelets: a critical determinant of prothrombotic function in circulation
Circulating platelets derived from bone marrow megakaryocytes play a central role in thrombosis and hemostasis. Despite being anucleate, platelets...
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Recurrent connectivity supports higher-level visual and semantic object representations in the brain
Visual object recognition has been traditionally conceptualised as a predominantly feedforward process through the ventral visual pathway. While...
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A rationale for considering heart/brain axis control in neuropsychiatric disease
Neuropsychiatric diseases (NPD) represent a significant global disease burden necessitating innovative approaches to pathogenic understanding,...
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Major regulators of the multi-step metastatic process are potential therapeutic targets for breast cancer management
Metastasis is a multi-step process that leads to the dissemination of tumor cells to new sites and, consequently, to multi-organ neoplasia. Although...
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Analysis of individual differences in neurofeedback training illuminates successful self-regulation of the dopaminergic midbrain
The dopaminergic midbrain is associated with reinforcement learning, motivation and decision-making – functions often disturbed in neuropsychiatric...
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Advancing forest inventorying and monitoring
Forests are under pressure and going through rapid changes. However, current inventorying and monitoring (IM) programs are often either disjointed,...
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CDCA8 promotes bladder cancer survival by stabilizing HIF1α expression under hypoxia
Hypoxia is an essential hallmark of solid tumors and HIF1α is a central regulator of tumor cell adaptation and survival in the hypoxic environment....
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PKCβII–ACSL4 Axis Triggers Ferroptosis and Its Potential Implication in Ferroptosis-Related Diseases
Ferroptosis is a regulated cell death process independent of apoptosis, triggered by excessive peroxidation of polyunsaturated fatty acids (PUFAs) in...
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Key research challenges to supporting farm transitions to agroecology in advanced economies. A review
In response to the sustainability issues that agriculture faces in advanced economies, agroecology has gained increasing relevance in scientific,...
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Rapid alkalinization factor 22 has a structural and signalling role in root hair cell wall assembly
Pressurized cells with strong walls make up the hydrostatic skeleton of plants. Assembly and expansion of such stressed walls depend on a family of...
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Modelling Tools and Plausible Scenarios in Science-Policy to Improve Evidence-Based Decision-Making for Human Well-Being
In the last few decades, there has been a tremendous interest among the global researchers and intergovernmental panels on climate and biodiversity...
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Integrating biocultural diversity into urban school grounds through transdisciplinary curriculum design
In these times of decreasing connection with nature, we are experiencing the loss of both biodiversity and cultural traditions. A sense of place,...
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Conspecific and heterospecific plant–soil biota interactions of Lonicera japonica in its native and introduced range: implications for invasion success
We tested the ‘enemy release hypothesis’ in relation to Lonicera japonica to determine the effects of soil microbes on plant growth. It was...
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Science for social licence to arrest an ecosystem-transforming invasion
The primary role for scientific information in addressing complex environmental problems, such as biological invasions, is generally assumed to be as...
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Adapting agroforestry to upland farming systems: narratives from smallholder farmers in Northwest Vietnam
Fruit tree–based agroforestry has been promoted as an alternative farming practice in upland Northwest Vietnam to replace monocultures of staple...
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Cortical-striatal brain network distinguishes deepfake from real speaker identity
Deepfakes are viral ingredients of digital environments, and they can trick human cognition into misperceiving the fake as real. Here, we test the...
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Dopamine improves defective cortical and muscular connectivity during bilateral control of gait in Parkinson’s disease
Parkinson’s Disease (PD)-typical declines in gait coordination are possibly explained by weakness in bilateral cortical and muscular connectivity....
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GPR56 signaling pathway network and its dynamics in the mesenchymal transition of glioblastoma
G protein-coupled receptor 56 (GPR56/ADGRG1) is a multifunctional adhesion GPCR involved in diverse biological processes ranging from development to...
