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Role of MMP-1, MMP-8 and MMP-9 gene polymorphisms in preterm birth
Novel approaches to preterm births are underway building upon our prior discoveries and probing into unknown discovery pathways. The recent findings...
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Whole-genome sequencing-based phylogeny, antibiotic resistance, and invasive phenotype of Escherichia coli strains colonizing the cervix of women in preterm labor
BackgroundEscherichia coli is a major neonatal pathogen and the leading cause of early-onset sepsis in preterm newborns. Maternal E. coli strains...
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Prenatal glucocorticoid administration accelerates the maturation of fetal rat hepatocytes
BackgroundPrenatal glucocorticoid (GC) is clinically administered to pregnant women who are at risk of preterm birth for the maturation of...
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The association between dyslipidaemia in the first trimester and adverse pregnancy outcomes in pregnant women with subclinical hypothyroidism: a cohort study
BackgroundSubclinical hypothyroidism (SCH) is linked to dyslipidaemia and adverse pregnancy outcomes. However, the impact of dyslipidaemia on the...
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Endotoxin content in neonatal formulas, fortification, and lactoferrin products: association with outcomes and guidance on acceptable limits
While endotoxin (lipopolysaccharide) can be harmful and contribute to morbidity and mortality with Gram-negative sepsis or necrotizing enterocolitis...
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Fetal meconium does not have a detectable microbiota before birth
Microbial colonization of the human intestine impacts host metabolism and immunity; however, exactly when colonization occurs is unclear. Although...
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Association of maternal HDL2-c concentration in the first trimester and the risk of large for gestational age birth
BackgroundMaternal lipid levels during pregnancy are critical for fetal development. Recent studies revealed that high-density lipoprotein...
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Anti-CCL2 therapy reduces oxygen toxicity to the immature lung
Oxygen toxicity constitutes a key contributor to bronchopulmonary dysplasia (BPD). Critical step in the pathogenesis of BPD is the inflammatory...
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Antimicrobial Resistance Pattern in E. coli Isolated from Placental Tissues of Pregnant Women in Low-Socioeconomic Setting of Pakistan
Infections during pregnancy can culminate in adverse pregnancy outcomes, including preterm birth (PTB). Pakistan is among the top ten nations with...
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Polymorphism of the IL-1β, TNF, IL-1RA and IL-4 Cytokine Genes Significantly Increases the Risk of Preterm Birth
Preterm birth is not only medical, but also a social problem. The global goal of medicine is prevention of preterm labor and identification of risk...
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Transcriptional profiling of lung macrophages identifies a predictive signature for inflammatory lung disease in preterm infants
Lung macrophages mature after birth, placing newborn infants, particularly those born preterm, within a unique window of susceptibility to disease....
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Effects of β-Lactam Antibiotics on Gut Microbiota Colonization and Metabolites in Late Preterm Infants
We usually refer to the critical period for intestinal flora establishment as infancy because the infant gut microbiota is characterized by low...
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Preeclampsia: Early and Long-Term Clinical Considerations
Preeclampsia is a hypertensive disorder of pregnancy characterized by new onset of hypertension after 20 weeks gestational age, in the setting of...
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IFI27 may predict and evaluate the severity of respiratory syncytial virus infection in preterm infants
BackgroundPreterm infants are a special population that vulnerable to respiratory syncytial virus (RSV) infection and the lower respiratory tract...
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Human 3D brain organoids: steering the demolecularization of brain and neurological diseases
Understanding of human brain development, dysfunction and neurological diseases has remained limited and challenging due to inability to recapitulate...
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Mechanics of the Left Ventricle in Children Born Prematurely
AbstractAn increase in the birth rate of premature and low birth weight children at the current level of medical development requires the development...
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Single cell transcriptomic analysis of human amnion identifies cell-specific signatures associated with membrane rupture and parturition
BackgroundThe human amnion is an intrauterine tissue which is involved in the initiation of parturition. In-depth understanding of gene expression...
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Lactobacillus plantarum L168 improves hyperoxia-induced pulmonary inflammation and hypoalveolarization in a rat model of bronchopulmonary dysplasia
Alteration of gut microbiota can affect chronic lung diseases, such as asthma and chronic obstructive pulmonary disease, through abnormal immune and...
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The immune-inflammatory response of oligodendrocytes in a murine model of preterm white matter injury: the role of TLR3 activation
A leading cause of preterm birth is the exposure to systemic inflammation (maternal/fetal infection), which leads to neuroinflammation and white...
