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Diverse functions associate with non-coding polymorphisms shared between humans and chimpanzees
BackgroundLong-term balancing selection (LTBS) can maintain allelic variation at a locus over millions of years and through speciation events....
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The role of non-classical and chain-related human leukocyte antigen polymorphisms in laryngeal squamous cell carcinoma
BackgroundLaryngeal squamous cell carcinoma (LSCC) is the major pathological subtype of laryngeal cancer. It has been shown that alterations of the...
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Identification of polymorphisms in GDF9 and BMP15 genes in Jamunapari and crossbred goats in Bangladesh
Polymorphisms in growth differentiation factor 9 ( GDF9 ) and bone morphogenetic protein 15 ( BMP15 ) genes have been found to be associated with litter...
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A Biochip for Genoty** Polymorphisms Associated with Eye, Hair, Skin Color, AB0 Blood Group, Sex, Y Chromosome Core Haplogroup, and Its Application to Study the Slavic Population
AbstractThis paper presents a method for genoty** a panel of 60 single nucleotide polymorphisms (SNPs) using single-stage PCR followed by...
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Modification Effects of Homologous Recombination Repair Gene Polymorphisms on the Associations Between Urinary Metals and Breast Cancer Risk
Metals are recognized as important factors related to breast cancer (BC) risk. Homologous recombination repair (HRR) genes might modify the toxicity...
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Association of SOD2 rs2758339, rs5746136 and rs2842980 polymorphisms with increased risk of breast cancer: a haplotype-based case–control study
BackgroundA growing body of evidence indicates that oxidative stress, high levels of reactive oxygen species (ROS), is implicated in the pathogenesis...
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Single Nucleotide Polymorphisms in the U86 Gene of Human betaherpesvirus 6B
AbstractThere are single publications dedicated to identifying and ty** the Human Herpesvirus type 6 (HHV-6) in the domestic scientific literature....
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Single nucleotide polymorphisms of Interleukin − 4, Interleukin-18, FCRL3 and sPLA2IIa genes and their association in pathogenesis of endometriosis
BackgroundEndometriosis is a complex gynaecological disorder that contributes to infertility, dysmenorrhea, dyspareunia, and other chronic issues. It...
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Characterisation of Single Nucleotide Polymorphisms and Haplotypes of MSTN Associated with Growth Traits in European Sea Bass (Dicentrarchus labrax)
The myostatin ( MSTN ) gene, known as growth differentiation factor-8 (GDF-8), is a member of the transforming growth factor-β (TGF-β) superfamily and...
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Do high-mobility group box 1 gene polymorphisms affect the incidence of differentiation syndrome in acute promyelocytic leukemia?
BackgroundDifferentiation syndrome (DS) is an inflammatory complication seen in some patients with acute promyelocytic leukemia (APL) undergoing...
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Analysis of ASIP and MC1R Gene Polymorphisms in Kabardin Horses
AbstractHorses’ coat color has been a subject of interest due to its aesthetic appeal and importance as a criterion for breed identification....
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Associations of CXCL12 polymorphisms with clinicopathological features in breast cancer: a case-control study
BackgroundPrevious studies suggested that CXCL12 was involved in the development, metastasis, and invasion of breast cancer, and genetic variants...
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Association of TP53 gene polymorphisms with the risk of acute lymphoblastic leukemia in Moroccan children
BackgroundTP53 gene plays a pivotal role in maintaining genetic stability and prevention of malignancies. Alterations of this gene are implicated in...
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Detecting Signatures of TE Polymorphisms in Short-Read Sequencing Data
Transposable elements (TEs) are an important cause of evolutionary change and functional diversity, yet they are routinely discarded in the first...
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The relationship between OXT gene polymorphisms and reproductive hormones in pregnant and lactating Awassi Ewes
BackgroundNumerous genetic loci interact intricately to control reproduction in mammals. The oxytocin gene ( OXT ) is a promising candidate for...
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Two remarkable serine/leucine polymorphisms in Helicobacter pylori: functional importance for serine protease HtrA and adhesin BabA
Single nucleotide polymorphisms (SNPs) account for significant genomic variability in microbes, including the highly diverse gastric pathogen Helicobac...
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Impact of VEGFA promoter polymorphisms on esophageal cancer risk in North-West Indians: a case-control study
BackgroundAngiogenesis play a critical role in the development and progression of tumors in solid tumors. Vascular endothelial growth factor (VEGF)...
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Relationship between rs4349859 and rs116488202 polymorphisms close to MHC-I region and serum urate levels in patients with gout
BackgroundGout is the most common inflammatory rheumatic disease and elevated levels of serum urate (SU) are the main cause for its development....
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Fyn and Lyn gene polymorphisms impact the risk of thyroid cancer
Thyroid cancer is the most common malignancy of the endocrine glands, and during last couple of decades, its incidence has risen alarmingly, across...
