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Identified eleven exon variants in PKD1 and PKD2 genes that altered RNA splicing by minigene assay
BackgroundAutosomal dominant polycystic kidney disease (ADPKD) is a common monogenic multisystem disease caused primarily by mutations in the PKD1 ...
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Metabolic Health and Disease: A Role of Osteokines?
Maintenance of skeletal health is tightly regulated by osteocytes, osteoblasts, and osteoclasts via coordinated secretion of bone-derived factors,...
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Role of Oxidative Stress in Chronic Kidney Disease
Kidneys are important organs of the renal system. Besides being one of the principal excretory organs of the body, these perform many important...
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Phosphorylation of MIF by PIP4K2a is necessary for cilia biogenesis
Primary cilia are microtubule-based organelles that play important roles in development and tissue homeostasis. Macrophage migration inhibitory...
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Extracellular Vesicles in Domestic Animals: Cellular Communication in Health and Disease
Apoptotic and healthy cells of domestic animals release membrane-enclosed particles from their plasma membrane. These special structures, called...
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Apoptotic cell death in disease—Current understanding of the NCCD 2023
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that...
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miRNA-486-5p: signaling targets and role in non-malignant disease
MicroRNAs (miRNAs) are short non-coding RNAs, highly conserved between species, that are powerful regulators of gene expression. Aberrant expression...
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When smoke meets gut: deciphering the interactions between tobacco smoking and gut microbiota in disease development
Tobacco smoking is a prevalent and detrimental habit practiced worldwide, increasing the risk of various diseases, including chronic obstructive...
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The enpp4 ectonucleotidase regulates kidney patterning signalling networks in Xenopus embryos
The enpp ectonucleotidases regulate lipidic and purinergic signalling pathways by controlling the extracellular concentrations of purines and...
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Microbial Biopharmaceuticals in Urolithiasis Management and Treatment
Urolithiasis is a potentially brutal condition characterized by the presence of insoluble deposits or stones in the kidneys and urinary tract. Among...
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Vitamin D and cardiovascular disease risk. A literature overview
BackgroundAtherosclerosis and cerebro and cardiovascular disease associated represent the major cause of morbidity and mortality worldwide. Recently,...
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Multi-omics Investigations in Endocrine Systems and Their Clinical Implications
Innovative techniques such as the “omics” can be a powerful tool for the understanding of intracellular pathways involved in homeostasis maintenance...
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Natural compounds proposed for the management of non-alcoholic fatty liver disease
Although non-alcoholic fatty liver disease (NAFLD) presents as an intricate condition characterized by a growing prevalence, the often-recommended...
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Centrosome as Center for Proteolytic Activity and Dysfunctions Associated with Pathogenesis of Human Disease
Among the multiple and intriguing roles of centrosomes in cellular functions is the ubiquitin–proteasome-mediated protein degradation. It has been...
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Stem/progenitor cell in kidney: characteristics, homing, coordination, and maintenance
Renal failure has a high prevalence and is becoming a public health problem worldwide. However, the renal replacement therapies such as dialysis are...
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Stem cells: a potential treatment option for kidney diseases
The prevalence of kidney diseases is emerging as a public health problem. Stem cells (SCs), currently considered as a promising tool for therapeutic...
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Blood Pressure: Changes Over a Woman’s Life, the Effect of Estrogen, and Special Considerations in Women
Hypertension is an important risk factor for cardiovascular disease in women and is one of the leading contributors to morbidity and mortality in...
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Low-dose 2-deoxyglucose and metformin synergically inhibit proliferation of human polycystic kidney cells by modulating glucose metabolism
Polycystic kidney disease (PKD) is a common hereditary kidney disease with abnormal proliferation and apoptosis of kidney cystic epithelial cells,...
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ANGPTL8 roles in proliferation, metabolic diseases, hypothyroidism, polycystic ovary syndrome, and signaling pathways
A new and atypical member of the ANGPTL family is angiopoietin-like protein 8 (ANGPTL8). This newly discovered hormone is a drug target that can be...
