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Transcriptomic analysis reveals the role of RcsB in suppressing bacterial chemotaxis, flagellar assembly and infection in Yersinia enterocolitica
Defining the Rcs (Regulator of Capsule Synthesis) regulon in Enterobacteriaceae has been the major focus of several recent studies. The overall role...
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Genomic Islands in Uropathogenic Escherichia coli
Discrete DNA segments known as genomic islands are responsible for establishing horizontally transmitted genes in a population. This region might be...
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Genomic and proteomic analysis of Salmonella Enteritidis isolated from a patient with foodborne diarrhea
Salmonella is a major cause of foodborne diseases and clinical infections worldwide. This study aimed to investigate the drug resistance, genomic...
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Investigation of the invasion mechanism mediated by the outer membrane protein PagN of Salmonella Typhimurium
BackgroundSalmonella can invade host cells via a type three secretion system called T3SS-1 and its outer membrane proteins, PagN and Rck. However,...
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The influence of oxygen and oxidative stress on de novo acquisition of antibiotic resistance in E. coli and Lactobacillus lactis
BackgroundBacteria can acquire resistance through DNA mutations in response to exposure to sub-lethal concentrations of antibiotics. According to the...
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The membrane-active polyaminoisoprenyl compound NV716 re-sensitizes Pseudomonas aeruginosa to antibiotics and reduces bacterial virulence
Pseudomonas aeruginosa is intrinsically resistant to many antibiotics due to the impermeability of its outer membrane and to the constitutive...
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Potential therapeutic approaches for a slee** pathogen: tuberculosis a case for bioinorganic chemistry
AbstractMycobacterium tuberculosis (Mtb) has an old history as a human pathogen and still kills over one million people every year. One key feature...
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Proteomic response of Escherichia coli to a membrane lytic and iron chelating truncated Amaranthus tricolor defensin
BackgroundPlant defensins are a broadly distributed family of antimicrobial peptides which have been primarily studied for agriculturally relevant...
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Evaluation of the antibacterial, antibiofilm, and anti-virulence effects of acetic acid and the related mechanisms on colistin-resistant Pseudomonas aeruginosa
BackgroundPseudomonas aeruginosa ( P. aeruginosa ) has been majorly implicated in the infection of burns, wounds, skin, and respiratory tract....
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Using next generation antimicrobials to target the mechanisms of infection
The remarkable impact of antibiotics on human health is being eroded at an alarming rate by the emergence of multidrug resistant pathogens. There is...
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The Standard Genetic Code Facilitates Exploration of the Space of Functional Nucleotide Sequences
The standard genetic code is well known to be optimized for minimizing the phenotypic effects of single-nucleotide substitutions, a property that was...
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Comprehensive probiogenomics analysis of the commensal Escherichia coli CEC15 as a potential probiotic strain
BackgroundProbiotics have gained attention for their potential maintaining gut and immune homeostasis. They have been found to confer protection...
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Prevalence and transmission risk of colistin and multidrug resistance in long-distance coastal aquaculture
Due to the wide use of antibiotics, intensive aquaculture farms have been recognized as a significant reservoir of antibiotic resistomes. Although...
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Transcriptional Regulation Between the Two Global Regulators RovA and CRP in Yersinia pestis biovar Microtus
Yersinia pestis is a dangerous bacterial pathogen that can cause plague. Both RovA and cyclic AMP receptor protein (cAMP-CRP) are required for...
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Comparative analysis of the Colistin resistance-regulating gene cluster in Klebsiella species
CrrAB two-component regulatory system is associated with colistin resistance in Klebsiella pneumoniae . Recently, some K. pneumoniae isolates lacking crrAB...
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Genomic characterization and molecular dating of the novel bacterium Permianibacter aggregans HW001T, which originated from Permian ground water
The Permian Basin is a unique ecosystem located in the southwest of the USA. An unanswered question is whether the bacteria in the Permian Basin...
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Maintenance of bacterial outer membrane lipid asymmetry: insight into MlaA
The outer membrane (OM) of Gram-negative bacteria acts as an effective barrier to protect against toxic compounds. By nature, the OM is asymmetric...
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Identification of host factors limiting the overexpression of recombinant Cu, Zn superoxide dismutase in Escherichia coli
ObjectiveSuperoxide dismutase (SOD) enzyme has implications in modulating the cell’s redox state. The study aims to explore the host genetic factors...
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Exploring the success of Brazilian endemic clone Pseudomonas aeruginosa ST277 and its association with the CRISPR-Cas system type I-C
BackgroundThe Brazilian endemic clone Pseudomonas aeruginosa ST277 carries important antibiotic resistance determinants, highlighting the gene...
