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First report of the prey of adult Hyperechia xylocopiformis (Walker) (Diptera, Asilidae) and new records of its occurrence in South India
The prey of adult Hyperechia xylocopiformis (Walker), the carpenter bee ( Xylocopa sp.) mimicking robber fly endemic to south India, is reported for...
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Acid-resistant enzymes: the acquisition strategies and applications
AbstractEnzymes have promising applications in chemicals, food, pharmaceuticals, and other variety products because of their high efficiency,...
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Extracellular signals regulate the biogenesis of extracellular vesicles
Extracellular vesicles (EVs) are naturally released membrane vesicles that act as carriers of proteins and RNAs for intercellular communication. With...
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In silico and in vivo neuropharmacological evaluation of two γ-amino acid isomers derived from 2,3-disubstituted benzofurans, as ligands of GluN1–GluN2A NMDA receptor
The GABAergic and glutamatergic neurotransmission systems are involved in seizures and other disorders of the central nervous system (CNS)....
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Centrosome-phagy: implications for human diseases
Autophagy is a prominent mechanism to preserve homeostasis and the response to intracellular or extracellular stress. Autophagic degradation can be...
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A custom-made AAV1 variant (AAV1-T593K) enables efficient transduction of Japanese quail neurons in vitro and in vivo
The widespread use of rodents in neuroscience has prompted the development of optimized viral variants for transduction of brain cells, in vivo....
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IK is essentially involved in ciliogenesis as an upstream regulator of oral-facial-digital syndrome ciliopathy gene, ofd1
BackgroundThe cilia are microtubule-based organelles that protrude from the cell surface. Abnormalities in cilia result in various ciliopathies,...
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PepQSAR: a comprehensive data source and information platform for peptide quantitative structure–activity relationships
Peptide quantitative structure–activity relationships (pQSARs) have been widely applied to the statistical modeling and empirical prediction of...
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Generation of mitochondria-rich kidney organoids from expandable intermediate mesoderm progenitors reprogrammed from human urine cells under defined medium
BackgroundThe kidneys require vast amounts of mitochondria to provide ample energy to reabsorb nutrients and regulate electrolyte, fluid, and blood...
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Vaccines for Parasitic Diseases of Fish
Globally, incidences of fish diseases caused by parasites have been on a rise, especially in intensive aquaculture practise, leading to considerable...
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An assessment of juvenile sand tiger (Carcharias taurus) activity patterns in a seasonal nursery using accelerometer transmitters
Telemetry transmitters incorporating accelerometers have recently emerged as powerful tools for investigating the activity patterns of individuals...
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Preimplantation Genetic Testing
The two most crucial factors limiting the success of assisted reproduction are the quality of the embryo and the endometrium. The lacuna in the...
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Adeno-associated virus 2 bound to its cellular receptor AAVR
Adeno-associated virus (AAV) is a leading vector for virus-based gene therapy. The receptor for AAV (AAVR; also named KIAA0319L) was recently...
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Revision of Rhynchoglossum (Gesneriaceae) in South India and Sri Lanka, reinstating R. scabrum based on a multi-sample molecular-morphological approach
We revised the genus Rhynchoglossum papuae in South India and Sri Lanka, investigating in particular the status of R. scabrum . Based on molecular...
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The senescence-associated secretory phenotype and its physiological and pathological implications
Cellular senescence is a state of terminal growth arrest associated with the upregulation of different cell cycle inhibitors, mainly p16 and p21,...
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Low-dose 2-deoxyglucose and metformin synergically inhibit proliferation of human polycystic kidney cells by modulating glucose metabolism
Polycystic kidney disease (PKD) is a common hereditary kidney disease with abnormal proliferation and apoptosis of kidney cystic epithelial cells,...
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Comprehensive binary interaction map** of τ phosphotyrosine sites with SH2 domains in the human genome: Implications for the rational design of self-inhibitory phosphopeptides to target τ hyperphosphorylation signaling in Alzheimer’s Disease
Human microtubule-associated protein Tau (τ) is abundant in the axons of neurons where it stabilizes microtubule bundles; abnormally...
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Identification of a unique 1,4-β-d-glucan glucohydrolase of glycoside hydrolase family 9 from Cytophaga hutchinsonii
AbstractCytophaga hutchinsonii is an aerobic cellulolytic soil bacterium that rapidly digests crystalline cellulose. The predicted mechanism by...
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Alternative Ligands at Melatonin Receptors
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that possesses a wide range of biological effects. Most of the main recognized effects of...
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Urine-derived induced pluripotent/neural stem cells for modeling neurological diseases
Neurological diseases are mainly modeled using rodents through gene editing, surgery or injury approaches. However, differences between humans and...
