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Production of all-male non-transgenic zebrafish by conditional primordial germ cell ablation
Many fish species exhibit remarkable sexual dimorphism, with males possessing numerous advantageous traits for commercial production by aquaculture...
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UAV-based imaging for selection of turfgrass drought resistant cultivars in breeding trials
This study evaluated UAV-imaging and ground-based platforms as nondestructive means of phenoty** drought resistant zoysiagrasses and assessed their...
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Two target gene activation pathways for orphan ERR nuclear receptors
Estrogen-related receptors (ERRα/β/γ) are orphan nuclear receptors that function in energy-demanding physiological processes, as well as in...
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Comparison of reversed-phase, hydrophilic interaction, and porous graphitic carbon chromatography columns for an untargeted toxicometabolomics study in pooled human liver microsomes, rat urine, and rat plasma
IntroductionUntargeted metabolomics studies are expected to cover a wide range of compound classes with high chemical diversity and complexity. Thus,...
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CRISPR-Cas9 mediated genome editing of Huntington’s disease neurospheres
BackgroundHuntington’s disease (HD) is a fatal genetic disease caused by polyglutamine aggregation encoded by an expanded CAG repeat in the...
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Assessment of the Mitochondrial Condition in CD4+ and CD8+ T-Lymphocytes from Healthy Subjects
AbstractDespite the active study of T-lymphocyte mitochondria under pathology, data on the organelles’ condition in healthy people are not presented...
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TRPA1 promotes the maturation of embryonic stem cell-derived cardiomyocytes by regulating mitochondrial biogenesis and dynamics
BackgroundCardiomyocytes derived from pluripotent stem cells (PSC-CMs) have been widely accepted as a promising cell source for cardiac drug...
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Sirtuin 6 is a key contributor to gender differences in acute kidney injury
Acute kidney injury (AKI) is rapidly increasing nowadays and at a high risk to progress into chronic kidney disease (CKD). Of note, men are more...
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miR-106b enhances human mesenchymal stem cell differentiation to spermatogonial stem cells under germ cell profile genes involved in TGF-b signaling pathways
Mesenchymal stem cells can be differentiated into tissue-specific cells. MicroRNAs (miRNAs) regulate the translation of mRNAs involved in the growth...
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TRIM9 promotes Müller cell–derived retinal stem cells to differentiate into retinal ganglion cells by regulating Atoh7
Glaucoma is a multifactorial, irreversible blinding eye disease characterized by a large number of retinal ganglion cell (RGC) deaths. Müller...
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Therapeutic effects of genistein in experimentally induced ulcerative colitis in rats via affecting mitochondrial biogenesis
Ulcerative colitis (UC) is an inflammatory bowel disease that affects the mucosa of the colon, resulting in severe inflammation and ulcers. Genistein...
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Reinforcement of repressive marks in the chicken primordial germ cell epigenetic signature: divergence from basal state resetting in mammals
BackgroundIn mammals, primordial germ cells (PGCs), the embryonic precursors of the germline, arise from embryonic or extra-embryonic cells upon...
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Genome Editing Mediated by Primordial Germ Cell in Chicken
Genome editing technology has facilitated the studies on exploring specific gene functions in diverse living organisms. The technology has also...
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Aging and short-term calorie restriction differently affect the cardiac and skeletal muscle expression of genes regulating energy substrate utilization in male rats
Aging affects the energy metabolism differently in the cardiac and skeletal muscles. The study aim was to assess the effects of short-term calorie...
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IRX5 promotes adipogenesis of hMSCs by repressing glycolysis
Iroquois homeobox transcription factor 5 (IRX5) plays a pivotal role in extramedullary adipogenesis, but little is known about the effects of IRX5 on...
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FGF19 increases mitochondrial biogenesis and fusion in chondrocytes via the AMPKα-p38/MAPK pathway
Fibroblast growth factor 19 (FGF19) is recognized to play an essential role in cartilage development and physiology, and has emerged as a potential...
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Long non-coding RNA Tug1 modulates mitochondrial and myogenic responses to exercise in skeletal muscle
BackgroundMitochondria have an essential role in regulating metabolism and integrate environmental and physiological signals to affect processes such...
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Effect of different muscle contraction mode on the expression of Myostatin, IGF-1, and PGC-1 alpha family members in human Vastus Lateralis muscle
Muscle contraction stimulates a transient change of myogenic factors, partly related to the mode of contractions. Here, we assessed the response of IGF -...
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Pyrroloquinoline quinone promotes human mesenchymal stem cell-derived mitochondria to improve premature ovarian insufficiency in mice through the SIRT1/ATM/p53 pathway
BackgroundDNA damage and oxidative stress induced by chemotherapy are important factors in the onset of premature ovarian insufficiency (POI)....
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Pepsinogen C expression–related lncRNA/circRNA/mRNA profile and its co-mediated ceRNA network in gastric cancer
The expression of pepsinogen C (PGC) is considered an ideal negative biomarker of gastric cancer, but its pathological mechanisms remain unclear....
