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Mesenchymal Stem Cell—Macrophage Crosstalk Provides Specific Exosomal Cargo to Direct Immune Response Licensing of Macrophages during Inflammatory Responses
Neurodegenerative diseases (NDDs) continue to be a significant healthcare problem. The economic and social implications of NDDs increase with...
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Ectopic ATP synthase stimulates the secretion of extracellular vesicles in cancer cells
Ectopic ATP synthase on the plasma membrane (eATP synthase) has been found in various cancer types and is a potential target for cancer therapy....
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Assays to Measure Purinoceptor Pore Dilation
The P2X7 receptor is a classic purinoceptor/ion channel. After activated by ATP, it opens a cation selective channel, which dilates to a large pore...
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Blocking P2X7 receptor ameliorates oxidized LDL-mediated podocyte apoptosis
The purpose of our research is to elucidate whether oxLDL activates P2X7R in cultured human podocytes and if the activation of P2X7R leads to...
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Assessment of Cell Adhesion After Purinoceptor Activation
Cell adhesion is a characteristic feature of phagocytic myeloid cells, which is important for several inflammatory processes, such as migration,...
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Pathological calcification in canine tendon-derived cells is modulated by extracellular ATP
Tendon calcification is a commonly associated with degenerative tendinopathy of the Achilles tendons in dogs. It is characterised by the formation of...
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The activation of dormant ependymal cells following spinal cord injury
Ependymal cells, a dormant population of ciliated progenitors found within the central canal of the spinal cord, undergo significant alterations...
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The interaction of inflammasomes and gut microbiota: novel therapeutic insights
Inflammasomes are complex platforms for the cleavage and release of inactivated IL-1β and IL-18 cytokines that trigger inflammatory responses against...
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Involvement of P2X7 Receptors in the Osteogenic Differentiation of Mesenchymal Stromal/Stem Cells Derived from Human Subcutaneous Adipose Tissue
The ionotropic P2X7 receptor (P2X7R) is involved in bone homeostasis but its role in osteogenesis is controversial. Thus, we investigated the...
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The NLRP3 inflammasome: contributions to inflammation-related diseases
The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the...
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Migraine signaling pathways: purine metabolites that regulate migraine and predispose migraineurs to headache
Migraine is a debilitating disorder that afflicts over 1 billion people worldwide, involving attacks that result in a throbbing and pulsating...
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Possible role of purinergic signaling in COVID-19
The coronavirus disease (COVID-19), caused by SARS-CoV-2 infection, accounts for more than 2.4 million deaths worldwide, making it the main public...
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Progress in the relationship between P2X7R and colorectal cancer
Purinergic ligand-gated ion channel 7 receptor (P2X7R) is a nonselective cation channel of the purinergic receptor family. P2X7R is activated by...
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Ferroptosis: a double-edged sword mediating immune tolerance of cancer
The term ferroptosis was put forward in 2012 and has been researched exponentially over the past few years. Ferroptosis is an unconventional pattern...
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The trigger for pancreatic disease: NLRP3 inflammasome
NLRP3 inflammasome is a multiprotein complex expressed in a variety of cells to stimulate the production of inflammatory factors. Activation of NLRP3...
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The role of Nod-like receptor protein 3 inflammasome activated by ion channels in multiple diseases
The inflammasome is a multimeric protein complex located in the cytoplasm that is activated by many factors and subsequently promotes the release of...
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Agonists and Antagonists for Purinergic Receptors
Membrane receptors that are activated by the purine nucleoside adenosine (adenosine receptors) or by purine or pyrimidine nucleotides (P2Y and P2X...
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Murine and Human-Purified very Small Embryonic-like Stem Cells (VSELs) Express Purinergic Receptors and Migrate to Extracellular ATP Gradient
Purinergic signaling is an ancient primordial signaling system regulating tissue development and specification of various types of stem cells. Thus,...
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Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease
BackgroundTubulointerstitial fibrosis represents the key underlying pathology of Chronic Kidney Disease (CKD), yet treatment options remain limited....
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Effect of Spinal Cord Injury on P2 Signaling in the Cholinergic Synapse
AbstractThoracic spinal cord injuries are well known to entail the degradation of spinal motoneurons, accompanied by axonal degeneration. In the...
