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NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury
Our understanding of how global changes in cellular metabolism contribute to human kidney disease remains incompletely understood. Here we show that...
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Distinct redox state regulation in the seedling performance of Norway maple and sycamore
Norway maple and sycamore, two Acer genus species, have an important ecological value and different sensitivity to stressing factors being currently...
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Downregulation of miR-182-5p by NFIB promotes NAD+ salvage synthesis in colorectal cancer by targeting NAMPT
Nuclear factor I B (NFIB) plays an important role in tumors. Our previous study found that NFIB can promote colorectal cancer (CRC) cell...
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Metabolic control of histone acetylation for precise and timely regulation of minor ZGA in early mammalian embryos
Metabolism feeds into the regulation of epigenetics via metabolic enzymes and metabolites. However, metabolic features, and their impact on...
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Transcriptome analysis reveals a molecular understanding of nicotinamide and butyrate sodium on meat quality of broilers under high stocking density
BackgroundIn recent years, increased attention has been focused on breast muscle yield and meat quality in poultry production. Supplementation with...
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Adjunctive therapy with lipid-lowering agents in COVID-19: a systematic review and meta-analysis of randomized controlled trials
BackgroundMany commonly used drugs were evaluated as repurposed treatment options since the emergence of the COVID-19 pandemic. The benefit of...
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Gut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia
Most cancer cells have high need for nicotinamide adenine dinucleotide (NAD + ) to sustain their survival. This led to the development of inhibitors of...
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Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity
Nicotinamide adenine dinucleotide (NAD + ) is a central metabolite in cellular processes. Depletion of NAD + has been demonstrated to be a prevalent...
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Photosynthetic Apparatus: Major Site of Oxidative Damage
Photosynthesis is the most crucial physiological process that converts solar energy into biomass and facilitates life sustenance on earth. The...
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Overexpression of nicotinamide mononucleotide adenylyltransferase (nmnat) increases the growth rate, Ca2+ concentration and cellulase production in Ganoderma lucidum
AbstractIdentifying new and economical means to utilize diverse lignocellulosic biomass is an urgent task. Ganoderma lucidum is a well-known edible...
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Mitochondria-targeted cyclometalated iridium (III) complex for H2S-responsive intracellular redox regulation as potent photo-oxidation anticancer agent
AbstractOwing to the safety and low toxicity, photodynamic therapy (PDT) for cancer treatment has received extensive attention. However, the excess H
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γ-Aminobutyric acid boosts chilling tolerance by promoting the methionine sulfoxide reductase-thioredoxin reductase system in peach fruit
The effects of γ-aminobutyric acid (GABA) on promotion of chilling tolerance and the methionine sulfoxide reductase (MSR)-thioredoxin reductase...
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Weak neuronal glycolysis sustains cognition and organismal fitness
The energy cost of neuronal activity is mainly sustained by glucose
1 ,2 . However, in an apparent paradox, neurons modestly metabolize glucose through...
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Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models
Impairment of autophagy leads to an accumulation of misfolded proteins and damaged organelles and has been implicated in plethora of human diseases....
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Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide
BackgroundNicotinamide (NAM) is a form of vitamin B3 that, when administered at near-gram doses, has been shown or suggested to be therapeutically...
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NADPH oxidase contributes to the production of reactive oxygen species in Chlorella pyrenoidosa
Reactive Oxygen Species (ROS) play an important role in oxidative stress and are related to the lipid accumulation in microalgae. Nicotinamide...
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Healthy aging and muscle function are positively associated with NAD+ abundance in humans
Skeletal muscle is greatly affected by aging, resulting in a loss of metabolic and physical function. However, the underlying molecular processes and...
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Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma
Glaucoma can result in retinal ganglion cell (RGC) death and permanently damaged vision. Pathologically high intraocular pressure (ph-IOP) is the...
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Utilizing transcriptomics and metabolomics to unravel key genes and metabolites of maize seedlings in response to drought stress
BackgroundDrought stress can substantially restrict maize growth and productivity, and global warming and an increasing frequency of extreme weather...
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Identification of autophagy-related genes in neuropathic pain through bioinformatic analysis
BackgroundNeuropathic pain (NP) is one of the most common types of chronic pain and significantly compromises the quality of life. Autophagy is an...
