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The destruction of mucosal barriers, epithelial remodeling, and impaired mucociliary clearance: possible pathogenic mechanisms of Pseudomonas aeruginosa and Staphylococcus aureus in chronic rhinosinusitis
Chronic rhinosinusitis (CRS) is a pathological condition characterized by persistent inflammation in the upper respiratory tract and paranasal...
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Spraying compound probiotics improves growth performance and immunity and modulates gut microbiota and blood metabolites of suckling piglets
One factor that shapes the establishment of early neonatal intestinal microbiota is environmental microbial exposure, and probiotic application has...
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Changes in intestinal microbiota, immunity and metabolism caused by mixed Lactiplantibacillus plantarum and Bacillus subtilis-fermented feed in Bamei pigs
BackgroundThe Chinese pig breed Bamei faces numerous challenges, such as antibiotic abuse, feed shortages, weaning stress, low immunity and disease...
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Evaluation of Cell-Penetrating Peptides as Mucosal Immune Enhancers for Nasal Vaccination
Cell-penetrating peptides (CPPs) have been evaluated as enhancers in drug delivery, their addition in medical formulations favors drug absorption...
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Crosstalk between vault RNAs and innate immunity
PurposeVault (vt) RNAs are noncoding (nc) RNAs transcribed by RNA polymerase III (RNA Pol III) with 5ʹ-triphosphate (5ʹ-PPP) termini that play...
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Dietary antarctic krill improves antioxidant capacity, immunity and reduces lipid accumulation, insights from physiological and transcriptomic analysis of Plectropomus leopardus
BackgroundDue to its enormous biomass, Antarctic krill ( Euphausia superba ) plays a crucial role in the Antarctic Ocean ecosystem. In recent years,...
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Effects of chlorogenic acid supplementation in high-fat diet on antioxidant capacity, immunity, and intestinal health of spotted sea bass (Lateolabrax maculatus)
This study explored the effects of chlorogenic acid (CGA) on antioxidant capacity, immunity, and intestinal health of spotted sea bass Lateolabrax...
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Activity of Humoral Antiendotoxin Immunity Is Associated with Low-Intensity Inflammation and Oxidative Stress in Ankylosing Spondylitis: Endotoxin Component of Disease Pathogenesis
AbstractClinical and laboratory examination was performed for 50 patients with ankylosing spondylitis (AS) (mean age 38.1 ± 1.3 years) with degree II...
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Nutritional immunity: the battle for nutrient metals at the host–pathogen interface
Trace metals are essential micronutrients required for survival across all kingdoms of life. From bacteria to animals, metals have critical roles as...
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Assessing the impact of chemoautotrophic and heterotrophic biofloc cultivation systems on the immunity and intestinal bacteriome of shrimp
The use of measures to prevent disease and enhance immune competence in shrimp is essential to ensure the sustainability of shrimp aquaculture. We...
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Combinatorial multimer staining and spectral flow cytometry facilitate quantification and characterization of polysaccharide-specific B cell immunity
Bacterial capsular polysaccharides are important vaccine immunogens. However, the study of polysaccharide-specific immune responses has been hindered...
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Human immune and gut microbial parameters associated with inter-individual variations in COVID-19 mRNA vaccine-induced immunity
COVID-19 mRNA vaccines induce protective adaptive immunity against SARS-CoV-2 in most individuals, but there is wide variation in levels of...
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Fucosylation of HLA-DRB1 regulates CD4+ T cell-mediated anti-melanoma immunity and enhances immunotherapy efficacy
Immunotherapy efficacy is limited in melanoma, and combinations of immunotherapies with other modalities have yielded limited improvements but also...
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Human Infant Fecal Microbiota Differentially Influences the Mucosal Immune Pathways Upon Influenza Infection in a Humanized Gnotobiotic Pig Model
In this study, we evaluated the impact of human gut microbiota on the immune pathways in the respiratory tract using a gnotobiotic (Gn) piglet model....
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Undenatured type II collagen protects against collagen-induced arthritis by restoring gut-joint homeostasis and immunity
Oral administration of harmless antigens can induce suppression of reactive immune responses, a process that capitalises on the ability of the...
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COVID-19 vaccine development based on recombinant viral and bacterial vector systems: combinatorial effect of adaptive and trained immunity
Severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2) infection, which causes coronavirus disease 2019 (COVID-19), has led to many cases...
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Viable and Heat-Killed Probiotic Strains Improve Oral Immunity by Elevating the IgA Concentration in the Oral Mucosa
Oral-nasal mucosal immunity plays a crucial role in protecting the body against bacterial and viral invasion. Safe probiotic products have been used...
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Innate Immunity Via Glycan-Binding Lectin Receptors
Recognition of glycans and transfer of information contained in the glycan structures are performed by carbohydrate-recognizing proteins of lectins...
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Commensal Bacillus pumilus SE5-Derived Peptidoglycan and Lipoteichoic Acid Showed Synergistic Effects in Improving Growth, Immunity, and Intestinal Health of Grouper (Epinephelus coioides)
Commensal-derived peptidoglycan (PG) or lipoteichoic acid (LTA) can improve the growth, immunity, and intestinal health of fish, but it is not clear...
