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Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation
During megakaryopoiesis, megakaryocytes (MKs) undergo cellular morphological changes with strong modification of membrane composition and lipid...
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Perilipin 5 deletion protects against nonalcoholic fatty liver disease and hepatocellular carcinoma by modulating lipid metabolism and inflammatory responses
The molecular mechanisms underlying the transition from nonalcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC) are incompletely...
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MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling
Ferroptosis is an iron-dependent form of cell death driven by biochemical processes that promote oxidation within the lipid compartment. Calcium (Ca 2+ ...
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Beyond energy provider: multifunction of lipid droplets in embryonic development
Since the discovery, lipid droplets (LDs) have been recognized to be sites of cellular energy reserves, providing energy when necessary to sustain...
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SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway
Pancreatic cancer (PC), a highly lethal malignancy, commonly exhibits metabolic reprogramming that results in therapeutic vulnerabilities....
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mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species
The mechanistic target of rapamycin complex 1 (mTORC1) senses and relays environmental signals from growth factors and nutrients to metabolic...
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GADD45A regulates subcutaneous fat deposition and lipid metabolism by interacting with Stat1
BackgroundObesity, characterized by excessive white adipose tissue expansion, is associated with several metabolic complications. Identifying new...
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Revolutionizing control strategies against Mycobacterium tuberculosis infection through selected targeting of lipid metabolism
Lipid species play a critical role in the growth and virulence expression of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis...
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Itaconic acid underpins hepatocyte lipid metabolism in non-alcoholic fatty liver disease in male mice
Itaconate, the product of the decarboxylation of cis -aconitate, regulates numerous biological processes. We and others have revealed itaconate as a...
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Nanotechnology Driven Lipid and Metalloid Based Formulations Targeting Blood–Brain Barrier (3B) for Brain Tumor
The evolution of nanotechnology-driven lipid and metalloid-based nanoformulations has garnered significant attention for develo** effective drug...
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Impairment of RPN4, a transcription factor, induces ER stress and lipid abnormality in Saccharomyces cerevisiae
Accumulation of misfolded/unfolded proteins in the endoplasmic reticulum (ER) induces ER stress. The transcription factor RPN4 {“Regulatory Particle...
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Lack of Nck1 protein and Nck-CD3 interaction caused the increment of lipid content in Jurkat T cells
BackgroundThe non-catalytic region of tyrosine kinase (Nck) is an adaptor protein, which is ubiquitously expressed in many types of cells. In T...
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Role of isotropic lipid phase in the fusion of photosystem II membranes
It has been thoroughly documented, by using 31 P-NMR spectroscopy, that plant thylakoid membranes (TMs), in addition to the bilayer (or lamellar, L)...
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Zika virus triggers autophagy to exploit host lipid metabolism and drive viral replication
BackgroundZika virus (ZIKV), an arbovirus of global concern, has been associated with neurological complications including microcephaly in newborns...
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Restoration of lipid homeostasis between TG and PE by the LXRα-ATGL/EPT1 axis ameliorates hepatosteatosis
Converting lipid disturbances in response to energy oversupply into healthy lipid homeostasis is a promising therapy to alleviate hepatosteatosis....
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Lipid Digestion and Bioaccessibility of Lipid-Soluble Compounds
An understanding of the digestion of lipids and the bioaccessibility of their derivatives (lipid-soluble compounds/molecules) after digestion is...
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Identification of porcine fast/slow myogenic exosomes and their regulatory effects on lipid accumulation in intramuscular adipocytes
BackgroundPork quality is affected by the type of muscle fibers, which is closely related to meat color, tenderness and juiciness. Exosomes are tiny...
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The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets
Lipid droplets (LDs) are crucial organelles for energy storage and lipid homeostasis. Autophagy of LDs is an important pathway for their catabolism,...
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Microfluidic platform enables tailored translocation and reaction cascades in nanoliter droplet networks
In the field of bottom-up synthetic biology, lipid membranes are the scaffold to create minimal cells and mimic reactions and processes at or across...
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Integrating Membrane Transporter Proteins into Droplet Interface Bilayers
Droplet interface bilayers (DIBs) are an emerging tool within synthetic biology that aims to recreate biological processes in artificial cells. A...