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Targeted integration in CHO cells using CRIS-PITCh/Bxb1 recombinase–mediated cassette exchange hybrid system
AbstractRecombinant Chinese hamster ovary (CHO) cell line development for complex biotherapeutic production is conventionally based on the random...
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Waxholm Space atlas of the rat brain: a 3D atlas supporting data analysis and integration
Volumetric brain atlases are increasingly used to integrate and analyze diverse experimental neuroscience data acquired from animal models, but until...
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DeepAutoGlioma: a deep learning autoencoder-based multi-omics data integration and classification tools for glioma subty**
Background and objectiveThe classification of glioma subtypes is essential for precision therapy. Due to the heterogeneity of gliomas, the...
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Multiscale temporal integration organizes hierarchical computation in human auditory cortex
To derive meaning from sound, the brain must integrate information across many timescales. What computations underlie multiscale integration in human...
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Dimensions of Morphological Integration
Over several generations of evolutionary and developmental biologists, ever since Olson and Miller’s pioneering work of the 1950’s, the concept of...
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Multivariate EEG activity reflects the Bayesian integration and the integrated Galilean relative velocity of sensory motion during sensorimotor behavior
Humans integrate multiple sources of information for action-taking, using the reliability of each source to allocate weight to the data. This...
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Identification and functional characterisation of a locus for target site integration in Fusarium graminearum
BackgroundFusarium Head Blight (FHB) is a destructive floral disease of different cereal crops. The Ascomycete fungus Fusarium graminearum ( Fg ) is...
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Phenotypic integration of pollination traits in a distylous species with high intra-individual floral variation
Plants are modular organisms, and flowers are their reproductive modules. Low intra-individual variation and high phenotypic integration are expected...
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Benchmarking atlas-level data integration in single-cell genomics
Single-cell atlases often include samples that span locations, laboratories and conditions, leading to complex, nested batch effects in data. Thus,...
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Single-cell multi-omics integration for unpaired data by a siamese network with graph-based contrastive loss
BackgroundSingle-cell omics technology is rapidly develo** to measure the epigenome, genome, and transcriptome across a range of cell types....
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Role of I182, R187, and K188 Amino Acid Residues in the Catalytic Domain of HIV-1 Integrase in the Processes of Reverse Transcription and Integration
AbstractStructural organization of HIV-1 integrase is based on a tetramer formed by two protein dimers. Within this tetramer, the catalytic domain of...
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The effect of data transformation on low-dimensional integration of single-cell RNA-seq
BackgroundRecent developments in single-cell RNA sequencing have opened up a multitude of possibilities to study tissues at the level of cellular...
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Integration of beef cattle international pedigree and genomic estimated breeding values into national evaluations, with an application to the Italian Limousin population
BackgroundInternational evaluations combine data from different countries allowing breeders to have access to larger panels of elite bulls and to...
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Work organization as a barrier to crop–livestock integration practices: a case study in Guadeloupe
Crop–livestock integration exploits the synergies between crop** and livestock systems, mainly by using animal excreta as an organic crop...
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Metabolomics and transcriptomics based multi-omics integration reveals radiation-induced altered pathway networking and underlying mechanism
Recent advancement in integrated multi-omics has significantly contributed to many areas of the biomedical field. Radiation research has also grasped...
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Parsimonious Clone Tree Integration in cancer
BackgroundEvery tumor is composed of heterogeneous clones, each corresponding to a distinct subpopulation of cells that accumulated different types...
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Mother’s Age and Social Integration Modulate Sex-biased Maternal Investment in Wild Spider Monkeys (Ateles geoffroyi)
In many mammal species, mothers are crucial for the survival and development of young offspring. In primates, maternal investment may ensure...
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RAISING is a high-performance method for identifying random transgene integration sites
Both natural viral infections and therapeutic interventions using viral vectors pose significant risks of malignant transformation. Monitoring for...
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Benchmarking spatial and single-cell transcriptomics integration methods for transcript distribution prediction and cell type deconvolution
Spatial transcriptomics approaches have substantially advanced our capacity to detect the spatial distribution of RNA transcripts in tissues, yet it...
