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The Role of 20-Hydroxyecdysone in the Control of Carbohydrate Levels in Drosophila melanogaster under Short-Term Heat Stress
AbstractIt is known that 20-hydroxyecdysone is one of the most important hormonal regulators of development, reproduction and adaptation to...
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Characterization of P2X7 Receptors in Human Blood Cells
P2X7 receptors are expressed in different circulating immune cells. Depending on the cell in which they are expressed, their function could vary from...
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Allium sativum Essential Oil Supplementation Reverses the Hepatic Inflammation, Genotoxicity and Apoptotic Effects in Swiss Albino Mice Intoxicated with the Lead Nitrate
Prolonged lead (Pb) exposure impairs human health due to its interference with physiological and biochemical processes. Therefore, it is necessary to...
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Oligonucleotide-Directed Protein Threading Through a Rigid Nanopore
Nanopore technology enables the detection and analysis of single protein molecules. The technique measures the ionic current passing through a single...
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Genotoxicity, DNA damage and sperm defects induced by vinblastine
BackgroundThe treatment with chemotherapy may develop secondary tumors as a result of chemo genotoxicity. Sperm defects is another complication...
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Mechanically-Evoked TRPV4-Mediated Currents Are Modulated by Activated Integrin β1
TRPV4 is a polymodal, non-selective cation channel which can be activated by mechanical stimuli only when they are applied directly at the...
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Silymarin and MSC-exosomes ameliorate thioacetamide-evoked renal fibrosis by inhibiting TGF-β/SMAD pathway in rats
BackgroundTGF-β1 and SMAD3 are particularly pathogenic in the progression of renal fibrosis.
AimThis study aimed to evaluate the kidney protective...
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Bioengineering of Halobacterium sp. NRC-1 gas vesicle nanoparticles with GvpC fusion protein produced in E. coli
AbstractGas vesicle nanoparticles (GVNPs) are hollow, buoyant prokaryotic organelles used for cell flotation. GVNPs are encoded by a large gas...
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A novel method to detect intracellular metabolite alterations in MCF-7 cells by doxorubicin induced cell death
BackgroundMetabolic reprogramming within cancer cells has been recognized as a potential barrier to chemotherapy. Additionally, metabolic tumor...
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Investigation of HCAR2 antagonists as a potential strategy to modulate bovine leukocytes
BackgroundDairy cows experiencing ketosis after calving suffer greater disease incidence and are at greater risk of leaving the herd. In vitro...
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Heat shock protein DNAJA2 regulates transcription-coupled repair by triggering CSB degradation via chaperone-mediated autophagy
Transcription-coupled nucleotide excision repair (TC-NER) is an important genome maintenance system that preferentially removes DNA lesions on the...
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Purification of Cdk-CyclinB-Kinase–Targeted Phosphopeptides from Nuclear Envelope
We describe a method for rapid identification of protein kinase substrates within the nuclear envelope. Open mitosis in higher eukaryotes is...
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lncRNA miR4458HG modulates hepatocellular carcinoma progression by activating m6A-dependent glycolysis and promoting the polarization of tumor-associated macrophages
Long non-coding RNAs (lncRNAs) play significant roles in different biological functions of cancers. However, their function in the metabolism of...
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Competence for neural crest induction is controlled by hydrostatic pressure through Yap
Embryonic induction is a key mechanism in development that corresponds to an interaction between a signalling and a responding tissue, causing a...
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The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia
BackgroundE3 ubiquitin ligases play critical roles in regulating cellular signaling pathways by inducing ubiquitylation of key components....
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Prediction of key amino acids of Salmonella phage endolysin LysST-3 and detection of its mutants’ activity
Salmonella Typhimurium, a zoonotic pathogen, causes systemic and localized infection. The emergence of drug-resistant S. Typhimurium has increased;...
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RMI1 facilitates repair of ionizing radiation–induced DNA damage and maintenance of genomic stability
Ionizing radiation (IR) causes a wide variety of DNA lesions, of which DNA double-stranded breaks (DSBs) are the most deleterious. Homologous...
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Neutralization of the Staphylococcus aureus Panton-Valentine leukocidin by African and Caucasian sera
BackgroundThe prevalence of Staphylococcus aureus isolates carrying the Panton-Valentine leukocidin (PVL) gene is higher in Africa (≈50%) compared...
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Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1
Conventional dogma presumes that protamine-mediated DNA compaction in sperm is achieved by electrostatic interactions between DNA and the...
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Characterization of the binding of cytosolic phospholipase A2 alpha and NOX2 NADPH oxidase in mouse macrophages
BackgroundPrevious studies have demonstrated that cytosolic phospholipase A 2 α (cPLA 2 α) is required for NOX2 NADPH oxidase activation in human and...
