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GM1 Ameliorates Lead-Induced Cognitive Deficits and Brain Damage Through Activating the SIRT1/CREB/BDNF Pathway in the Develo** Male Rat Hippocampus
Developmental lead (Pb) exposure involves various serious consequences, especially leading to neurotoxicity. In this study, we examined the possible...
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Membrane attachment and fusion of HIV-1, influenza A, and SARS-CoV-2: resolving the mechanisms with biophysical methods
Attachment to and fusion with cell membranes are two major steps in the replication cycle of many human viruses. We focus on these steps for three...
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Chemical and Physicochemical Properties of Gangliosides
In this chapter, we briefly describe the structural features of gangliosides, and focus on the peculiar chemicophysical features of gangliosides, an...
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Recent advances in carbohydrate-based cancer vaccines
Cancer is a complex multifactorial disease for which many promising therapeutic strategies such as immunotherapy are emerging. Malignant cells...
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Nuclear Magnetic Resonance of Gangliosides
Structure, conformation, and dynamics of sphingolipids can provide substantial help in better understanding sphingolipid–ligand interaction...
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Molecular Dynamics of Gangliosides
Computational methodologies have immense potential to delineate the dynamic conformations of glycoconjugates including gangliosides, thereby...
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Studies on the interactions of neutral Galleria mellonella cecropin D with living bacterial cells
Cecropins constitute an important family of insect antimicrobial peptides involved in humoral innate immune response. In comparison with the highly...
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Radioactive Gangliosides for Biological Studies
In this chapter, we present the preparation of gangliosides isotopically labelled with 3H or 14C. The methods do not present specific difficulties...
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Glycan Array Technology
Glycan (or carbohydrate) arrays have become an essential tool in glycomics, providing fast and high-throughput data on protein-carbohydrate...
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Ganglioside Metabolism and Its Inherited Diseases
Gangliosides are sialic acid containing glycosphingolipids, which are abundant in mammalian brain tissue. Several fatal human diseases are caused by...
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Anti-ganglioside Antibodies in Peripheral Nerve Pathology
Anti-ganglioside antibodies are principally associated with autoimmune peripheral neuropathies. In these disorders, immune attack is inadvertently...
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Mitochondria-associated ER membranes (MAMs) and lysosomal storage diseases
Lysosomal storage diseases (LSDs) comprise a large group of disorders of catabolism, mostly due to deficiency of a single glycan-cleaving hydrolase....
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Gangliosides of the Nervous System
This review begins by attempting to recount some of the pioneering discoveries that first identified the presence of gangliosides in the nervous...
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Chemical Synthesis of Gangliosides
Various methods for the chemical synthesis of gangliosides have been investigated to date and numerous natural gangliosides and their structural...
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Campylobacter jejuni: collective components promoting a successful enteric lifestyle
Campylobacter jejuni is the leading cause of bacterial diarrhoeal disease in many areas of the world. The high incidence of sporadic cases of disease...
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Enzyme and microbial technology for synthesis of bioactive oligosaccharides: an update
Oligosaccharides, in either free or bound forms, play crucial roles in a wide range of biological processes. Increasing appreciation of their roles...
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Synthesis of Photoactivatable and Paramagnetic Gangliosides
For the physicochemical studies aimed at elucidating the dynamic of gangliosides in membranes and their interaction with proteins and membrane...
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The many faces (and phases) of ceramide and sphingomyelin II – binary mixtures
A rather widespread idea on the functional importance of sphingolipids in cell membranes refers to the occurrence of ordered domains enriched in...
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Glycointeractions in bacterial pathogenesis
Many important interactions between bacterial pathogens and their hosts are highly specific binding events that involve host or pathogen carbohydrate...
