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Reliability of a novel approach for reference-based cell type estimation in human placental DNA methylation studies
The placenta is a central organ during early development, influencing trajectories of health and disease. DNA methylation (DNAm) studies of human...
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WNT and NOTCH signaling in human trophoblast development and differentiation
Correct development of the human placenta and its differentiated epithelial cells, syncytial trophoblasts (STBs) and extravillous trophoblasts...
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Interactions between host and gut microbiota in gestational diabetes mellitus and their impacts on offspring
Gestational diabetes mellitus (GDM) is characterized by insulin resistance and low-grade inflammation, and most studies have demonstrated gut...
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Single-cell characterization of self-renewing primary trophoblast organoids as modeling of EVT differentiation and interactions with decidual natural killer cells
BackgroundExtravillous trophoblast cell (EVT) differentiation and its communication with maternal decidua especially the leading immune cell type...
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A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health
Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased neonatal morbidity, as well as with pregnancy complications and...
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Distinctive aspects of the placental epigenome and theories as to how they arise
The placenta has a methylome dramatically unlike that of any somatic cell type. Among other distinctions, it features low global DNA methylation,...
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Antenatal Ultrasound Imaging for Analysis of Human Craniosynostosis
The cranial sutures can be imaged sonographically in the fetus as early as the end of the first trimester; however, fetal position and maternal body...
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Snail mediates GDF-8-stimulated human extravillous trophoblast cell invasion by upregulating MMP2 expression
BackgroundExtravillous trophoblast (EVT) cell invasion is a tightly regulated process that requires for a normal pregnancy. The...
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The expression of miRNA encoded by C19MC and miR-371-3 strongly varies among individual placentas but does not differ between spontaneous and induced abortions
miRNAs of the largest human miRNA gene cluster at all, i.e., C19MC, are almost exclusively expressed in the placenta. Nevertheless, only little is...
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PD-L1 enhances migration and invasion of trophoblasts by upregulating ARHGDIB via transcription factor PU.1
As the main constituent cells of the human placenta, trophoblasts proliferate, differentiate, and invade the uterine endometrium via a series of...
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Segmental hair metabolomics analysis in pregnant women with pregnancy complications
IntroductionPregnancy complications, as preeclampsia (PE) and HELLP syndrome, occurring with similar pathophysiological mechanisms, have adverse...
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Regulation of human trophoblast gene expression by endogenous retroviruses
The placenta is a fast-evolving organ with large morphological and histological differences across eutherians, but the genetic changes driving...
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GDF-11 downregulates placental human chorionic gonadotropin expression by activating SMAD2/3 signaling
BackgroundThe production of human chorionic gonadotropin (hCG) by the placental trophoblast cells is essential for maintaining a normal pregnancy....
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Blockade of stromal cell-derived factor-1 signaling disturbs the invasiveness of human extravillous trophoblast cells
BackgroundThe invasion of trophoblast cells into the maternal uterine decidua is crucial for the formation of the placenta and establishment of...
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Role of Albumin and Alpha-Fetoprotein in Prenatal Ontogenesis of the Human Eye
AbstractThe vitreous body of the eye of human fetuses contains serum albumin (SA) and alpha-fetoprotein (AFP), which is normally characteristic of...
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Fetal mortality associated with backfat thickness at first mating and first farrowing of the primiparous sows raised in a commercial herd in Thailand
This study aimed to investigate the fetal mortality, including stillborn piglets (SB) and mummified fetuses (MM), in relation to backfat thickness...
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Characterization of placental and decidual cell development in early pregnancy loss by single-cell RNA sequencing
BackgroundEarly pregnancy loss (EPL) presents as sporadic or recurrent miscarriage during the first trimester. In addition to chromosomal defects,...
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Association between placental DNA methylation and fetal congenital heart disease
Congenital heart disease (CHD) is a worldwide problem with high morbidity and mortality. Early diagnosis of congenital heart disease is still a...
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Up-regulated mRNA expression of VEGFA receptors (FLT1 and KDR) in placentas after assisted reproductive technology fertilization
Placental angiogenesis is a pivotal process for feto-maternal circulation and ensures efficient development of the placenta throughout pregnancy....
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Birth Size Outcomes in Relation to Maternal Blood Levels of Some Essential and Toxic Elements
Exposures to toxic trace elements and deficiencies of essential trace elements during pregnancy may impact fetal growth. This study was conducted to...
