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BMP4 enhances anoikis resistance and chemoresistance of breast cancer cells through canonical BMP signaling
Bone morphogenetic proteins (BMPs) regulate cell fate during development and mediate cancer progression. In this study, we investigated the role of...
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Skin benefits of postbiotics derived from Micrococcus luteus derived from human skin: an untapped potential for dermatological health
BackgroundThe skin microbiome, a diverse community of microorganisms, plays a crucial role in maintaining skin health. Among these microorganisms,...
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Chromatin profiling and state predictions reveal insights into epigenetic regulation during early porcine development
BackgroundGiven their physiological similarities to humans, pigs are increasingly used as model organisms in human-oriented biomedical studies....
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CDK7 in breast cancer: mechanisms of action and therapeutic potential
Cyclin-dependent kinase 7 (CDK7) serves as a pivotal regulator in orchestrating cellular cycle dynamics and gene transcriptional activity. Elevated...
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Single-cell RNA sequencing reveals the transcriptional heterogeneity of Tbx18-positive cardiac cells during heart development
The T-box family transcription factor 18 (Tbx18) has been found to play a critical role in regulating the development of the mammalian heart during...
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Differential expression analysis of mRNAs, lncRNAs, and miRNAs expression profiles and construction of ceRNA networks in PEDV infection
BackgroundPorcine Epidemic Diarrhea Virus (PEDV) is a coronavirus that seriously affects the swine industry. MicroRNAs and long noncoding RNAs are...
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Metabolites and gene expression in the myocardium of fasting rats in an acute hypoxic environment
With the rising demand for entry to extremely high altitudes (HAs), rapid adaptability to extremely hypoxic environments is a challenge that we need...
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Multiple Fra-1-bound enhancers showing different molecular and functional features can cooperate to repress gene transcription
BackgroundHow transcription factors (TFs) down-regulate gene expression remains ill-understood, especially when they bind to multiple enhancers...
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An integrated multi-omics approach to identify regulatory mechanisms in cancer metastatic processes
BackgroundMetastatic progress is the primary cause of death in most cancers, yet the regulatory dynamics driving the cellular changes necessary for...
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Sodium Ions as Regulators of Transcription in Mammalian Cells
AbstractThe maintenance of an uneven distribution of Na + and K + ions between the cytoplasm and extracellular medium is the basis for the functioning...
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DDX5 inhibits type I IFN production by promoting degradation of TBK1 and disrupting formation of TBK1 − TRAF3 complex
DExD/H-box helicase (DDX) 5 belongs to the DExD/H-box helicase family. DDX family members play differential roles in the regulation of innate...
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Expression of cell proliferation regulatory factors bricd5, tnfrsf21, cdk1 correlates with expression of clock gene cry1 in testes of Hu rams during puberty
BackgroundCryptochrome 1 ( cry1 ), the core regulator of the circadian clock, is essential for ontogeny and mammalian reproduction. Unlike in other...
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Genomic dissection and mutation-specific target discovery for breast cancer PIK3CA hotspot mutations
BackgroundRecent advancements in high-throughput genomics and targeted therapies have provided tremendous potential to identify and therapeutically...
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Retinoic acid modulation guides human-induced pluripotent stem cell differentiation towards left or right ventricle-like cardiomyocytes
BackgroundCardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) by traditional methods are a mix of atrial and ventricular...
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The clinical significance of circulating DSCAM-AS1 in patients with ER-positive breast cancer and construction of its competitive endogenous RNA network
AbstractLong Non-Coding RNAs (lncRNAs), with diagnostic and therapeutic applications in malignancies, are newly described tumour-related molecules....
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Single-cell transcriptomics reveals cellular heterogeneity and molecular stratification of cervical cancer
Cervical cancer (CC) is the most common gynecological malignancy, whose cellular heterogeneity has not been fully understood. Here, we performed...
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YY1 regulates the proliferation and invasion of triple-negative breast cancer via activating PLAUR
It is well-established that breast cancer is a highly prevalent malignancy among women, emphasizing the need to investigate mechanisms underlying its...
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Wnt signaling and Loxl2 promote aggressive osteosarcoma
Osteosarcoma (OS) is the most frequent primary malignant bone tumor in urgent need of better therapies. Using genetically modified mouse models...
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SH3RF2 contributes to cisplatin resistance in ovarian cancer cells by promoting RBPMS degradation
Platinum-based chemotherapy remains one of the major choices for treatment of ovarian cancer (OC). However, primary or acquired drug resistance...
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Histone H3K36me2 demethylase KDM2A promotes bladder cancer progression through epigenetically silencing RARRES3
Epigenetic dysregulation contributes to bladder cancer tumorigenesis. H3K36me2 demethylase KDM2A functions as an important epigenetic regulator of...
