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The origins of haplotype 58 (H58) Salmonella enterica serovar Typhi
Antimicrobial resistance (AMR) poses a serious threat to the clinical management of typhoid fever. AMR in Salmonella Typhi ( S . Typhi) is commonly...
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Direct Detection of Fluoroquinolone Resistance in Sputum Samples from Tuberculosis Patients by High Resolution Melt Curve Analysis
Multidrug-resistant tuberculosis (MDR-TB) requires treatment with fluoroquinolone (FLQ) drugs, however, the excessive use of FLQ has led to the rise...
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Natural antibiotics against antimicrobial resistance: sources and bioinspired delivery systems
The current burden associated to multidrug resistance, and the emerging superbugs, result in a decreased and even loss of antibiotic efficacy, which...
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Polymyxin B Heteroresistance and Adaptive Resistance in Multidrug- and Extremely Drug-Resistant Acinetobacter baumannii
Acinetobacter baumannii is an emerging pathogen associated with nosocomial infections and multidrug resistance. Polymyxin B has been used to treat...
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Recent advances in therapeutic targets identification and development of treatment strategies towards Pseudomonas aeruginosa infections
The opportunistic human pathogen Pseudomonas aeruginosa is the causal agent of a wide variety of infections. This non-fermentative Gram-negative...
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Landscape of internal N7-methylguanosine of long non-coding RNA modifications in resistant acute myeloid leukemia
BackgroundGrowing evidence indicates that RNA methylation plays a fundamental role in epigenetic regulation, which is associated with the...
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LncRNA MCM3AP-AS1 promotes chemoresistance in triple-negative breast cancer through the miR-524-5p/RBM39 axis
Triple-negative breast cancer (TNBC) is the most lethal subtype of BC, with unfavorable treatment outcomes. Evidence suggests the engagement of...
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Solithromycin in Combination with Other Antimicrobial Agents Against the Carbapenem Resistant Klebsiella pneumoniae (CRKP)
Klebsiella pneumoniae is considered as the most common pathogen of hospital-acquired pneumonia. K. pneumoniae has emerged as the superbug which had...
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E3 ubiquitin ligase UBR5 promotes gemcitabine resistance in pancreatic cancer by inducing O-GlcNAcylation-mediated EMT via destabilization of OGA
Pancreatic cancer (PC) is among the deadliest malignancies, with an extremely poor diagnosis and prognosis. Gemcitabine (GEM) remains the first-line...
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Evolution and epidemic success of Mycobacterium tuberculosis in eastern China: evidence from a prospective study
BackgroundLineage distribution of Mycobacterium tuberculosis ( Mtb ) isolates is strongly associated with geographically distinct human populations,...
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Anti-Acinetobacter baumannii single-chain variable fragments provide therapeutic efficacy in an immunocompromised mouse pneumonia model
BackgroundThe emergence of carbapenem-resistant and extensively drug-resistant (XDR) Acinetobacter baumannii as well as inadequate effective...
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Necroptosis induced by ruthenium (II) complexes as mitochondrial disruptors
Inducing necroptosis in cancer cells has emerged as an effective strategy to overcome drug resistance. However, while organic small molecules have...
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Genomic Islands in Nutritional Fitness and Adaptation
Genomic islands have attracted wide attention and are extensively used to study the evolution and adaptation strategies of drug-resistant pathogenic...
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Molecular Ty** of Multidrug-Resistant Acinetobacter baumannii Isolates from Clinical Specimens by ERIC-PCR and MLVA
Acinetobacter baumannii , a Gram-negative and oxidase-negative bacterium, is a major cause of nosocomial infections, leading to high mortality rates...
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Therapeutic Applications of Nanotechnology in the Prevention of Infectious Diseases
In the area of drugs, nanoparticles are studied broadly for their extraordinary chemical and physical behaviors which are size dependent. Their...
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Elevated HMGB1 promotes the malignant progression and contributes to cisplatin resistance of non-small cell lung cancer
BackgroundHMGB1 (high mobility group box B-1) exhibits crucial role in tumor genesis and development, including lung cancer. Whereas, more...
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Antifungal synergistic effects and anti-biofilm formation activities of some bioactive 2,3-dihydro-1,5-benzoxazepine derivatives
Benzoxazepines constitute a significant class of organic compounds extensively described in the literature. Several derivatives with pharmacological...
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The use of combination therapy for the improvement of colistin activity against bacterial biofilm
Colistin is used as a last resort for the management of infections caused by multi-drug resistant (MDR) bacteria. However, the use of this antibiotic...
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The emergence of clonally diverse carbapenem-resistant Enterobacter cloacae complex in West Bengal, India: a dockyard of β-lactamases periling nosocomial infections
Carbapenem-resistant Enterobacter cloacae complex (CRECC) constitutes a global public health threat challenging clinical treatment and infection...
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Genomic Characterization of Two NDM-5-Producing Isolates of Klebsiella pneumoniae ST11 from a Single Patient
Two metallo-β-lactamase-producing Klebsiella pneumoniae (HA30 and HA31) were isolated in a hospital in Argentina during 2018. K. pneumoniae HA30 was...