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β-Hydroxybutyric acid improves cognitive function in a model of heat stress by promoting adult hippocampal neurogenesis
Heat stress has multiple potential effects on the brain, such as neuroinflammation, neurogenesis defects, and cognitive impairment. β-hydroxybutyric...
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FKBP51 modulates hippocampal size and function in post-translational regulation of Parkin
AbstractFK506-binding protein 51 (encoded by Fkpb51 , also known as Fkbp5 ) has been associated with stress-related mental illness. To investigate its...
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In vivo cyclic overexpression of Yamanaka factors restricted to neurons reverses age-associated phenotypes and enhances memory performance
In recent years, there has been success in partially reprogramming peripheral organ cells using cyclic Yamanaka transcription factor (YF) expression,...
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Influence of Surgical Trauma in the Nasal Cavity on the Expression of p53 Protein in the Hippocampus of Rats
AbstractThe aim of the study was to determine the role of the stress effect of septoplasty modeling on p53 protein expression in the hippocampus of...
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Prolonged fixation and post-mortem delay impede the study of adult neurogenesis in mice
Adult hippocampal neurogenesis (AHN) gives rise to new neurons throughout life. This phenomenon takes place in more than 120 mammalian species,...
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Early postnatal defects in neurogenesis in the 3xTg mouse model of Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder leading to dementia. The hippocampus, which is one of the sites where neural...
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Gene count normalization in single-cell imaging-based spatially resolved transcriptomics
BackgroundRecent advances in imaging-based spatially resolved transcriptomics (im-SRT) technologies now enable high-throughput profiling of targeted...
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Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG
BackgroundCognitive dysfunction (CD) is common among patients with the autoimmune disease systemic lupus erythematosus (SLE). Anti-ribosomal P...
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Markers of Neuroontogenesis in the Stress-Hyporesponsive Period: a Comparison of Laboratory Rodents and Humans
AbstractIt is commonly accepted now that a number of neuropsychiatric diseases are associated with early life stress. Various rodent models are used...
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Prenatal Introduction of Dexamethasone Causes Disruption of Glucocorticoid Feedback Associated with a Change in the Amount of Corticosteroid Receptors in Extrahypothalamic Brain Structures of Adult Rats
Abstract —As are other artificial glucocorticoids, dexamethasone is widely used in everyday obstetric practice. The threat of termination of pregnancy...
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Neurogenesis in the Hippocampus of Mice Exposed to Short-Term Hindlimb Unloading
AbstractLong-term spaceflights and simulated microgravity negatively affect the number of cognitive functions, including memory, learning, spatial...
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Hippocampus under Pressure: Molecular Mechanisms of Development of Cognitive Impairments in SHR Rats
AbstractData from clinical trials and animal experiments demonstrate relationship between chronic hypertension and development of cognitive...
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Quantitative characterization of proliferative cells subpopulations in the hilus of the hippocampus of adult Wistar rats: an integrative study
The hilus plays an important role modulating the excitability of the hippocampal dentate gyrus (DG). It also harbors proliferative cells whose...
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Investigation of de novo mutations in a schizophrenia case-parent trio by induced pluripotent stem cell-based in vitro disease modeling: convergence of schizophrenia- and autism-related cellular phenotypes
BackgroundDe novo mutations (DNMs) have been implicated in the etiology of schizophrenia (SZ), a chronic debilitating psychiatric disorder...
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Enhanced excitability but mature action potential waveforms at mossy fiber terminals of young, adult-born hippocampal neurons in mice
Adult-born granule neurons pass through immature critical periods where they display enhanced somatic excitability and afferent plasticity, which is...
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Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-β plaque and phosphorylated tau deposition and corresponding behavioral deficits
Sepsis is a severe systemic inflammatory response to infection associated with acute and chronic neurocognitive consequences, including an increased...
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Dietary polyphenols enhance optogenetic recall of fear memory in hippocampal dentate gyrus granule neuron subpopulations
Grape-derived polyphenols have been investigated for their role in promoting memory in model systems of stress, but little is known about select...
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Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair
Due to its complex and multifaceted nature, develo** effective treatments for epilepsy is still a major challenge. To deal with this complexity we...
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Loss of PML nuclear bodies in familial amyotrophic lateral sclerosis-frontotemporal dementia
Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are two neurodegenerative disorders that share genetic causes and pathogenic...
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Nitroxidergic and Calretinin-Containing Nonpyramidal Neurons of Rat Hippocampus
Abstract—Unlike pyramidal neurons, interneurons of the hippocampus are a heterogeneous group of neurons that differ in their morphological,...
