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Antimicrobial effect of anacardic acid–loaded zein nanoparticles loaded on Streptococcus mutans biofilms
Bacterial biofilms play a key role in the pathogenesis of major oral diseases. Nanoparticles open new paths for drug delivery in complex structures...
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Self-assembled micelles loaded with itraconazole as anti-Acanthamoeba nano-formulation
Acanthamoeba castellanii are opportunistic pathogens known to cause infection of the central nervous system termed: granulomatous amoebic...
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A comparison of culture-based, real-time PCR, droplet digital PCR and flow cytometric methods for the detection of Burkholderia cepacia complex in nuclease-free water and antiseptics
The presence of Burkholderia cepacia complex (BCC) strains has resulted in recalls of pharmaceutical products, since these opportunistic pathogens...
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Mining on Alzheimer’s diseases related knowledge graph to identity potential AD-related semantic triples for drug repurposing
BackgroundTo date, there are no effective treatments for most neurodegenerative diseases. Knowledge graphs can provide comprehensive and semantic...
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Potential sources of water contamination in Sulaymaniyah city hospitals: isolation and identification of non-fermentative gram-negative bacteria
The World Health Organization guidelines prioritize the detection of coliform bacteria as indicators of water contamination. However,...
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Methods for Transepicardial Cell Transplantation in a Swine Myocardial Infarction Model
The transplantation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) has garnered significant attention as a potential means of...
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Maintenance of bacterial outer membrane lipid asymmetry: insight into MlaA
The outer membrane (OM) of Gram-negative bacteria acts as an effective barrier to protect against toxic compounds. By nature, the OM is asymmetric...
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Determination of efflux activity in Enterococci by Hoechst accumulation assay and the role of zinc oxide nanoparticles in inhibition of this activity
BackgroundContribution of efflux pumps in development of antimicrobial resistance has been largely addressed in Gram negative and to a much lesser...
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Molecular epidemiological characteristics of carbapenem-resistant Klebsiella pneumoniae among children in China
Klebsiella pneumoniae infection and antimicrobial resistance among children are major concerns. The occurrence of hypervirulent K. pneumoniae (hvKp)...
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Learning from Nature: Naturally Derived Remedies
The rise and spread of antimicrobial resistance among microbes represents one of today’s most pressing global health issues. To combat the...
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Antarctic fungi produce pigment with antimicrobial and antiparasitic activities
Natural pigments have received special attention from the market and industry as they could overcome the harm to health and the environmental issues...
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Enterococcus faecium: evolution, adaptation, pathogenesis and emerging therapeutics
The opportunistic pathogen Enterococcus faecium colonizes humans and a wide range of animals, endures numerous stresses, resists antibiotic treatment...
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Noninvasive Measurement of Retinal Microvascular Permeability During Loss of Endothelial Quiescence
In the retina EC dysfunction and angiogenesis are driven by an altered microenvironment e.g., diabetes, leading to hypoxia and inflammation in the...
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Evaluation of ethanol and EDTA concentrations in the expression of biofilm-producing smf-1, rpfF genes in XDR clinical isolates of Stenotrophomonas maltophilia
BackgroundStenotrophomonas maltophilia is able to cause infections in immunocompromised patients, and the treatment of this opportunistic pathogen...
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A comprehensive review on phytochemistry, pharmacology, preclinical, and clinical trials of Cydonia oblonga
Cydonia oblonga M. (Quince), a deciduous shrub from the family Rosaceae , has been recognized in the last decade mainly because of its potential to...
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Application of Drug Repurposing-Based Precision Medicine Platform for Leukaemia Patient Treatment
Drug resistance in leukaemia is a major problem that needs to be addressed. Precision medicine provides an avenue to reduce drug resistance through a...
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Current and Future Applications to Control Polymicrobial Biofilms Associated with Oral Disease
In 1683, Antony van Leeuwenhoek made drawings of “little animals” taken from scra**s from the teeth observed under his newly invented microscope....
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Modeling and Assessing Osteoarthritis in Mice by Destabilization of the Medial Meniscus (DMM)
In this chapter, we describe an induced model of osteoarthritis in mice, frequently employed in the study of this disease. We outline in detail the...
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Surgical Methods for Cardiac Gene Delivery in Large Animals
This chapter describes main strategies of surgical gene delivery in large animals. Existing methods of cardiac gene transfer can be classified by the...