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Aloe vera-induced apoptotic cell death through ROS generation, cell cycle arrest, and DNA damage in human breast cancer cells
This study aimed to evaluate the in vitro cytotoxicity of ethanolic extract of Aloe vera (AVE) against human cancer cell lines. Cytotoxic effect of...
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Antineoplastic effects of erufosine on small cell and non-small cell lung cancer cells through induction of apoptosis and cell cycle arrest
BackgroundLung cancer (LC) is the most common types of cancer worldwide and is marked by high mortality rate. LC is classified into two major types...
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CARD9 contributes to ovarian cancer cell proliferation, cycle arrest, and cisplatin sensitivity
BackgroundOvarian cancer recurrence and chemotherapy resistance are still urgent issues, and exploring the mechanisms of metastasis and chemotherapy...
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miR-575/RIPK4 axis modulates cell cycle progression and proliferation by inactivating the Wnt/β-catenin signaling pathway through inhibiting RUNX1 in colon cancer
Receptor interacting protein serine/threonine kinase 4 (RIPK4) is widely involved in human cancer development. Nevertheless, its role in colon cancer...
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Toward a Comparative Systems Biology of the Alphaproteobacterial Cell Cycle
This chapter outlines how important properties of the bacterial cell cycle arose during evolution, and how it has been integrated to sustain...
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RASAL2 regulates the cell cycle and cyclin D1 expression through PI3K/AKT signalling in prostate tumorigenesis
Prostate cancer (PCa) growth and progression are uniquely dependent on androgens, making the androgen receptor pathway a prime target for therapy;...
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Thymol Enhances 5-Fluorouracil Cytotoxicity by Reducing Migration and Increasing Apoptosis and Cell Cycle Arrest in Esophageal Cancer Cells: An In-vitro Study
Esophageal cancer (EC) is a common cancer globally and has a low survival rate because it is often diagnosed at a late-stage, and is frequently...
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Polysaccharide extracted from the Sargassum fusiforme induces cell cycle arrest and apoptosis of B16F10 melanoma cells through the PI3K/AKT pathway
Background. Sargassum fusiforme( S. fusiforme ) is a brown alga that has been utilized as a medicine for a long time. Polysaccharides extracted from S....
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Temporal Control of Promoter Activity During the Caulobacter Cell Cycle
A cascade of cellular events must occur to allow cells to complete one round of cell division. Such a successful cell division cycle relies on the...
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Involvement of cell cycle and ion transferring in the salt stress responses of alfalfa varieties at different development stages
BackgroundAlfalfa ( Medicago sativa ) is the worldwide major feed crop for livestock. However, forage quality and productivity are reduced by salt...
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IDH1 mutation produces R-2-hydroxyglutarate (R-2HG) and induces mir-182-5p expression to regulate cell cycle and tumor formation in glioma
BackgroundMutations in isocitrate dehydrogenase 1 and 2 ( IDH1 and IDH2 ), are present in most gliomas. IDH1 mutation is an important prognostic...
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Pan-cancer surveys indicate cell cycle-related roles of primate-specific genes in tumors and embryonic cerebrum
BackgroundDespite having been extensively studied, it remains largely unclear why humans bear a particularly high risk of cancer. The antagonistic...
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New roles for AP-1/JUNB in cell cycle control and tumorigenic cell invasion via regulation of cyclin E1 and TGF-β2
BackgroundJUNB transcription factor contributes to the formation of the ubiquitous transcriptional complex AP-1 involved in the control of many...
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Molecular mechanisms of bilirubin induced G1 cell cycle arrest and apoptosis in human breast cancer cell lines: involvement of the intrinsic pathway
BackgroundBilirubin, as an essential constituent of cellular signaling pathways, may have a role in cell growth and apoptosis in breast cancer,...
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Unveiling the methionine cycle: a key metabolic signature and NR4A2 as a methionine-responsive oncogene in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is a deadly malignancy with notable metabolic reprogramming, yet the pivotal metabolic feature driving ESCC...
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LncRNA TARID induces cell proliferation through cell cycle pathway associated with coronary artery disease
Background/aimLong non-coding RNA TARID (lncRNA TARID ) can activate the tumor suppressor TCF21 in tumorigenesis by inducing promoter demethylation....
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Molecular insights into the Ebola virus life cycle
Ebola virus and other orthoebolaviruses cause severe haemorrhagic fevers in humans, with very high case fatality rates. Their non-segmented...
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Brucella abortus, a Pathogenic Rhizobiale with a Complex Cell Cycle
Brucella abortus in a pathogenic Rhizobiale able to survive and replicate inside host cells. B. abortus shares many features of the Rhizobiales,...
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Universal prediction of cell-cycle position using transfer learning
BackgroundThe cell cycle is a highly conserved, continuous process which controls faithful replication and division of cells. Single-cell...
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Cell density-dependent membrane distribution of ganglioside GM3 in melanoma cells
Monosialoganglioside GM3 is the simplest ganglioside involved in various cellular signaling. Cell surface distribution of GM3 is thought to be...
