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Investigation of Atrial Natriuretic Peptide as A Competitive Inhibitory Candidate Against Wnt/β-Catenin Signalling: A Molecular Dynamics Approach
Wnt/β-catenin signaling, a highly evolutionary conserved pathway, is abnormally regulated in many human cancers. This pathway is one of the proposed...
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RhoA/Rock activation represents a new mechanism for inactivating Wnt/β-catenin signaling in the aging-associated bone loss
The Wnt/β-catenin signaling pathway appears to be particularly important for bone homeostasis, whereas nuclear accumulation of β-catenin requires the...
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Long noncoding RNA H19: functions and mechanisms in regulating programmed cell death in cancer
Long noncoding RNAs (lncRNAs) are a group of noncoding RNAs with transcript lengths of >200 nucleotides. Mounting evidence suggests that lncRNAs are...
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Targeted activation of ferroptosis in colorectal cancer via LGR4 targeting overcomes acquired drug resistance
Acquired drug resistance is a major challenge for cancer therapy and is the leading cause of cancer mortality; however, the mechanisms of drug...
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Stem Cell‐based Dental Pulp Regeneration: Insights From Signaling Pathways
Deep caries, trauma, and severe periodontitis result in pulpitis, pulp necrosis, and eventually pulp loss. However, no clinical therapy can...
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The role of hypoxia on prostate cancer progression and metastasis
Prostate cancer is the second most common cancer diagnosed in men and the fifth-leading cause of cancer death in men worldwide. Like any solid tumor,...
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The ER membrane protein complex subunit Emc3 controls angiogenesis via the FZD4/WNT signaling axis
The endoplasmic reticulum (ER) membrane protein complex (EMC) regulates the synthesis and quality control of membrane proteins with multiple...
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The involvement of E3 ubiquitin ligases in the development and progression of colorectal cancer
To date, colorectal cancer (CRC) still has limited therapeutic efficacy and poor prognosis and there is an urgent need for novel targets to improve...
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Molecular insights into therapeutic promise of targeting of Wnt/β-catenin signaling pathway in obesity
Obesity is a curable disorder which is a global health concern, linked to an excess amount of fat. It is caused by inherited and environmental...
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sFRP1 Expression Induces miRNAs That Modulate Wnt Signaling in Chronic Myeloid Leukemia Cells
AbstractChronic myeloid leukemia is a clonal hematopoietic stem cell disease characterized by myeloid expansion. The hallmark of the disease is the...
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Protease associated domain of RNF43 is not necessary for the suppression of Wnt/β-catenin signaling in human cells
BackgroundRNF43 and its homolog ZNRF3 are transmembrane E3 ubiquitin ligases frequently mutated in many human cancer types. Their main role relays on...
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Morphological neurite changes induced by porcupine inhibition are rescued by Wnt ligands
BackgroundWnt signaling plays key roles in cellular and physiological processes, including cell proliferation, differentiation and migration during...
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Frizzled class receptor 5 contributes to ovarian cancer chemoresistance through aldehyde dehydrogenase 1A1
BackgroundChemoresistance is associated with tumor relapse and unfavorable prognosis. Multiple mechanisms underlying chemoresistance have been...
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Transcriptome analysis of sexual dimorphism in dorsal down coloration in goslings
BackgroundIn day-old Hungarian white goose goslings, there is a noticeable difference in dorsal down coloration between males and females, with...
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The cancer/testis antigen HORMAD1 mediates epithelial–mesenchymal transition to promote tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway in lung cancer
The cancer/testis antigen HORMAD1 is a mechanical regulator that modulates DNA homologous recombination repair and mismatch repair in multiple...
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CYTOR-NFAT1 feedback loop regulates epithelial-mesenchymal transition of retinal pigment epithelial cells
Epithelial mesenchymal transition (EMT) occurring in retinal pigment epithelial cells (RPE) is a crucial mechanism that contributes to the...
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Targeting CD24 as a novel immunotherapy for solid cancers
Cluster of differentiation 24 (CD24), a mucin-like highly glycosylated molecule has been extensively studied as a cancer stem cell marker in a...
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Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer's disease mouse model
BackgroundImpaired pattern separation occurs in the early stage of Alzheimer’s disease (AD), and hippocampal dentate gyrus (DG) neurogenesis...
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Drugs and Endogenous Factors as Protagonists in Neurogenic Stimulation
Neurogenesis is a biological process characterized by new neurons formation from stem cells. For decades, it was believed that neurons only...
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Genetic Testing in Endometrial Cancer
Endometrial carcinoma is one of the most commonly occurring gynecological malignancies. It is diagnosed mostly at the age of 50, yet 5% of cases...