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A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including Omicron
We are amid the historic coronavirus infectious disease 2019 (COVID-19) pandemic. Imbalances in the accessibility of vaccines, medicines, and...
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Ribokinase screened from T7 phage displayed Mycobacterium tuberculosis genomic DNA library had good potential for the serodiagnosis of tuberculosis
Tuberculosis caused by Mycobacterium tuberculosis ( M. tuberculosis ) is the leading cause of death among infectious diseases in the worldwide. Lack of...
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From antimicrobial to anticancer: the pioneering works of Prof. Luiz Rodolpho Travassos on bioactive peptides
Prof. Luiz Rodolpho Travassos, a distinguished Brazilian scientist, was instrumental in fostering an interdisciplinary research approach that...
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A theoretical strategy for acceleration of human immune response against SARS-CoV-2: a fusion protein harboring virus-binding and pre-exposed antigen domains
Coronavirus disease 2019 (COVID-19) is a respiratory disease that outbreaks since December 2019 and spread globally. Various methods have been used...
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A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts
SARS-CoV-2 infection causes COVID-19. Several clinical reports have linked COVID-19 during pregnancy to negative birth outcomes and placentitis....
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Construction of Naïve and Immune Human Fab Phage Display Library
Phage display has been applied successfully for the rapid isolation of monoclonal antibodies against various targets including infectious diseases,...
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Preparation and identification of a single domain antibody specific for adenovirus vectors and its application to the immunoaffinity purification of adenoviruses
Adenovirus belongs to the family of Adenoviridae. As a vaccine carrier, it has high safety and stimulates the body to produce cellular immunity and...
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Phage nanoparticle as a carrier for controlling fungal infection
AbstractA mass of nanocarriers have been exploited and utilized for prevention of fungi, including organic nanomaterials, inorganic nanoparticles,...
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Selection of a fully human single domain antibody specific to Helicobacter pylori urease
Helicobacter pylori bacteria are involved in gastroduodenal disorders, including gastric adenocarcinoma. Since the current therapies encounter with...
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A review on camelid nanobodies with potential application in veterinary medicine
The single variable domains of camelid heavy-chain only antibodies, known as nanobodies, have taken a long journey since their discovery in 1989...
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Vom Huhn abgeleitete Antikörper für Diagnostik und Immuntherapie
Due to the large evolutionary distance between birds (Aves) und humans, immunization of chickens with human proteins results in a strong response of...
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A Phage Display Derived Cyclized Peptide Inhibits Fibrosarcoma Cells Invasion via Suppression of MMP-9 Activity
Matrix metalloproteinases (MMPs) play critical roles in the invasiveness of cancerous cells and metastasis of solid tumors. MMP-9 is a member of this...
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Nanobodies in the fight against infectious diseases: repurposing nature's tiny weapons
Nanobodies are the smallest known antigen-binding molecules to date. Their small size, good tissue penetration, high stability and solubility, ease...
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A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug
SARS-CoV-2 infection is initiated by Spike glycoprotein binding to the human angiotensin-converting enzyme 2 (ACE2) receptor via its receptor binding...
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Nanobody against PDL1
Programmed death ligand 1 (PDL1, CD274, B7-H1) has been identified as the ligand for the immune inhibitory receptor programmed death 1 protein...
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Construction and evaluation of an antibody phage display library targeting heparan sulfate
Heparan sulfate (HS) is a linear polysaccharide with high structural diversity. Different HS epitopes have been detected and localized using single...
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Protein Engineering: Advances in Phage Display for Basic Science and Medical Research
AbstractFunctional Protein Engineering became the hallmark in biomolecule manipulation in the new millennium, building on and surpassing the...
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Generation of a new therapeutic d-peptide that induces the differentiation of acute myeloid leukemia cells through A TLR-2 signaling pathway
Acute myeloid leukemia (AML) is caused by clonal disorders of hematopoietic stem cells. Differentiation therapy is emerging as an important treatment...
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Affinity-binding immobilization of d-amino acid oxidase on mesoporous silica by a silica-specific peptide
Enzyme immobilization is widely used for large-scale industrial applications. However, the weak absorption through physical methods limits the...
